The southwest mountainous area is a frequent debris flow disaster area in China, which poses a serious threat to the regional roads and greatly affects the normal traffic operation and the safety of residents' lives and property. The debris flow risk assessment of highway can quantify the threat degree of debris flow to the roads. In this paper, from the perspective of villages and towns, taking the upper reaches of Minjiang River as the research area, four factors including road network density, highway disaster resistance capacity, population density and highway cost are selected, and the weight is obtained by using entropy weight method, and the debris flow vulnerability evaluation results of highway are obtained by weighted calculation. Four indexes of debris flow density, shape factor, relative height difference and annual rainfall are selected to evaluate the debris flow hazard of highway by using the information method. Based on the vulnerability and hazard evaluation results, the risk of highway debris flow is evaluated, and the results are classified and discussed. The results show that: the risk of debris flow on the upper reaches of Minjiang River is relatively low, the overall spatial distribution shows a trend of high in the East and low in the west, and the overall risk of township roads in Wenchuan county is the highest; The risk of debris flow is generally high within −10 to 30 km from the central fault zone of Longmenshan.