Large-Scale Encapsulation of Magnetic Iron Oxide Nanoparticles via Syngas Photo-Initiated Chemical Vapor Deposition

Farhanian, Donya; Crescenzo, Grégory De; Tavares, Jason Robert

doi:10.1038/s41598-018-30802-1

Cited by 27 publications

(12 citation statements)

References 64 publications

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“…For example, besides enhancing their biocompatibility, their encapsulation can control the nanoparticles blood circulation time, ease the development of nanotheranostics strategies and even increase the sensitivity of MRI compared with free metal nanoparticles by enhancing the contrast signal. [17][18][19] Lipid nanoemulsions can offer several advantages compared to other organic nanoplatforms. More in detail, these systems show higher loading capacity of lipophilic drugs and/or contrast agents due to their oily core and excellent colloidal stability due to the polar functional groups at their outer surface.…”

Section: Introductionmentioning

confidence: 99%

Manganese Ferrite Nanoparticles Encapsulated into Vitamin E/Sphingomyelin Nanoemulsions as Contrast Agents for High‐Sensitive Magnetic Resonance Imaging

Díez‐Villares

Ramos-Docampo

Silva‐Candal

et al. 2021

Adv Healthcare Materials

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Magnetic resonance imaging (MRI) is one of the most powerful non-invasive imaging modalities used in clinics due to its great spatial resolution and excellent soft-tissue contrast, though still less sensitive than other techniques such as the nuclear imaging modalities. This lack of sensitivity can be improved with the use of contrast agents based on nanomaterials. In recent years, researchers have focused on the development of magnetic nanoparticles, given their role as enhancers of the contrast signal based on the magnetic resonance. Manganese ferrite nanoparticles stand out, given their high magnetic susceptibility and magnetic soft nature. Herein, 10 nm MnFe 2 O 4 nanoparticles, functionalized with the natural antioxidant vitamin E (VitE-MFO) are encapsulated into simple, biodegradable and non-toxic nanoemulsions (NEs), by a reproducible one-step method obtaining stable 150 nm-sized magnetic nanoemulsions (VitE-MFO-NEs). After encapsulation, the superparamagnetic properties of VitE-MFO are maintained and MR imaging studies reveal an extremely high transverse relaxivity for VitE-MFO-NEs (652.9 × 10 −3 m −1 s −1 ), twofold higher than VitE-MFO value. Moreover, VitE-MFO-NEs show great in vivo biocompatibility and good signal in in vivo and ex vivo MRI, which indicates their great potential for biomedical imaging enhancing the negative MR contrast and significantly improving the sensitivity of MRI.

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Section: Introductionmentioning

confidence: 99%

Manganese Ferrite Nanoparticles Encapsulated into Vitamin E/Sphingomyelin Nanoemulsions as Contrast Agents for High‐Sensitive Magnetic Resonance Imaging

Díez‐Villares

Ramos-Docampo

Silva‐Candal

et al. 2021

Adv Healthcare Materials

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“…[ 65–68 ] Thermal methods like sputter deposition, vapor deposition (physical deposition, PVD, and chemical vapor deposition, CVD) is found in the literature. [ 45,69 ] However, complicated clean‐room instrumentation limits their application. The more recent methods of MNP synthesis incorporate the so‐called “green” synthesis process.…”

Section: Synthesis Of Mnpsmentioning

confidence: 99%

Recent progress of magnetic nanoparticles in biomedical applications: A review

et al. 2021

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Magnetic nanoparticles (MNPs) offer tremendous potentialities in biomedical applications for a long while. Since these materials' interactions in biological media largely rely on their crystal structures, sizes, and shapes, detailed studies on their synthesis mechanism for medicinal aspects are crucial. Despite many review reports that have already been published on MNPs, they mainly have focused either on their perspective in biomedical applications or their synthesis and characterization along with functionalization mechanisms as individual entities. For this reason, this review uncovers a comprehensive insight into the ongoing improvement of fabrication processes, surface functionalization of MNPs for biomedical applications together. Besides, various magnetic nanocomposite (MNCs) for smart drug delivery, recent hyperthermia treatment, lab‐on‐a‐chip, and magnetic bio‐separation, and some of the recent emerging imaging techniques using MNPs are discussed. A detailed analysis of toxicity, challenges, and recent progress of clinical trials of MNPs is sketched out to open numerous entryways for advanced research on MNPs for biomedical applications.

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“…Various novel Fe 3 O 4 NPs with surface coatings (Wu et al., 2020 ) and immobilized ligands (Xu et al., 2014 ) have been fabricated for use in the point‐of‐care field (Xianyu et al., 2018 ). Various methods have been developed to synthesize MNPs such as coprecipitation (Yazdani & Seddigh, 2016 ), microemulsion (Lakshmanan et al., 2014 ), thermal decomposition (Unni et al., 2017 ), solvothermal (Kim et al., 2018 ), sonochemical (Wang et al., 2015 ), microwave‐assisted (Kostyukhin et al., 2020 ), chemical vapor deposition (Farhanian et al., 2018 ), combustion (Kooti & Sedeh, 2013 ), carbon arc (Brunsman et al., 1994 ), and laser pyrolysis (Alexandrescu et al., 2010 ). Among these methods, coprecipitation is the most widely used and most proper method for MNP synthesis with which the sizes of the particles can be controlled to around 9 nm (Soytaş et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Chimeric nanocomposites for the rapid and simple isolation of urinary extracellular vesicles

Dao

Kim

Koo

et al. 2022

J of Extracellular Vesicle

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Cancer cell‐derived extracellular vesicles (EVs) are promising biomarkers for cancer diagnosis and prognosis. However, the lack of rapid and sensitive isolation techniques to obtain EVs from clinical samples at a sufficiently high yield limits their practicability. Chimeric nanocomposites of lactoferrin conjugated 2,2‐bis(methylol)propionic acid dendrimer‐modified magnetic nanoparticles (LF‐bis‐MPA‐MNPs) are fabricated and used for simple and sensitive EV isolation from various biological samples via a combination of electrostatic interaction, physically absorption, and biorecognition between the surfaces of the EVs and the LF‐bis‐MPA‐MNPs. The speed, efficiency, recovery rate, and purity of EV isolation by the LF‐bis‐MPA‐MNPs are superior to those obtained by using established methods. The relative expressions of exosomal microRNAs (miRNAs) from isolated EVs in cancerous cell‐derived exosomes are verified as significantly higher than those from noncancerous ones. Finally, the chimeric nanocomposites are used to assess urinary exosomal miRNAs from urine specimens from 20 prostate cancer (PCa), 10 benign prostatic hyperplasia (BPH), patients and 10 healthy controls. Significant up‐regulation of miR‐21 and miR‐346 and down‐regulation of miR‐23a and miR‐122‐5p occurs in both groups compared to healthy controls. LF‐bis‐MPA‐MNPs provide a rapid, simple, and high yield method for human excreta analysis in clinical applications.

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Large-Scale Encapsulation of Magnetic Iron Oxide Nanoparticles via Syngas Photo-Initiated Chemical Vapor Deposition

Cited by 27 publications

References 64 publications

Manganese Ferrite Nanoparticles Encapsulated into Vitamin E/Sphingomyelin Nanoemulsions as Contrast Agents for High‐Sensitive Magnetic Resonance Imaging

Manganese Ferrite Nanoparticles Encapsulated into Vitamin E/Sphingomyelin Nanoemulsions as Contrast Agents for High‐Sensitive Magnetic Resonance Imaging

Recent progress of magnetic nanoparticles in biomedical applications: A review

Chimeric nanocomposites for the rapid and simple isolation of urinary extracellular vesicles

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