Southern Manzhouli experienced a tectonic regime transformation from compression to extension in the late Mesozoic, but there is a lack of petrological and detailed chronological evidence. In addition, the lack of research on volcanic lithofacies and eruption sequence restricted the study of magmatic evolution and the division and correlation of regional volcanic rock strata. Based on systematic research of volcanics, volcanic facies, chronology and geochemistry, two stages of volcanics were identified; the first stage named trachyte series was formed in the late Middle Jurassic (167Ma‐163Ma), its eruption rhythm is pyroxene trachyandesite‐trachyandesite‐trachyte, and its origin rock is basic volcanics from thickened lower crust, and the tectonic setting is the collision orogeny after the closure of Mongolia Okhotsk Ocean. The second stage is a bimodal volcanic rock, formed in the early Late Jurassic (163Ma‐160Ma). The eruption rhythm of basic volcanics of the second stage is basaltic andesite‐basalt‐olivine basalt, which comes from the metasomatized lithospheric mantle, the acidic volcanic of it is characterized by the eruption rhythm of sedimentary facies‐explosive facies‐overflow facies, and came from the partial melting of newly formed lower crust, which shows the characteristics of A‐type granite. The tectonic setting of the second stage is the extension of the lithosphere after the collision of Mongolia Okhotsk Ocean. The changes in the formation age and tectonic setting of the two stages volcanics demonstrated that the transition time from the compressive system to the extensional system in the southern Manzhouli is about 163 Ma.