Large-scale multimodal surface neural interfaces for primates

Belloir, Tiphaine; Vargo, Sergio Montalvo; Ahmed, Z.; Griggs, Devon J.; Fisher, Shawn; Brown, Timothy; Chamanzar, Maysamreza; Yazdan-Shahmorad, Azadeh

doi:10.1016/j.isci.2022.105866

Cited by 4 publications

(7 citation statements)

References 157 publications

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“…The 𝜇-ECoG signals during the epilepsy activity reveal a sizeable negative peak amplitude of 9.8 μA, low noise of 0.63 nA, and SNR of 23.8 dB, which has a similar brain waveform with previous reports at the ictal onset. [7] The high-fidelity recordings of 𝜇-ECoG and evoked potentials in the demonstration of electric stimuli are consistent with the movie frames in Figure 4f. It has been divided into four stages: stable exogenous response (stage-I), the first endogenous response (stage-II), the second endogenous response (stage-III), and quiet period (stage-IV), revealing the propagation of neural spikes and associated spatiotemporally resolved patterns.…”

Section: In Vivo Characterizationsupporting

confidence: 78%

“…The μ‐ECoG signals during the epilepsy activity reveal a sizeable negative peak amplitude of 9.8 µA, low noise of 0.63 nA, and SNR of 23.8 dB, which has a similar brain waveform with previous reports at the ictal onset. [ 7 ]…”

Section: Resultsmentioning

confidence: 99%

“…Neural interfaces that record EP signals rely on electrical mechanism and can be established by passive microelectrodes and active transistors. [ 7 , 8 , 9 , 10 ] Brain activities are of low amplitude and interfered with various ex/internal sources. [ 11 ] To capture EP signal cleanly, strategy of optimizing materials selection and device design were introduced to reduce the impedance in passive microelectrodes.…”

Section: Introductionmentioning

confidence: 99%

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Ultrathin, Soft, Bioresorbable Organic Electrochemical Transistors for Transient Spatiotemporal Mapping of Brain Activity

Yao

Huang

et al. 2023

Advanced Science

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A critical challenge lies in the development of the next‐generation neural interface, in mechanically tissue‐compatible fashion, that offer accurate, transient recording electrophysiological (EP) information and autonomous degradation after stable operation. Here, an ultrathin, lightweight, soft and multichannel neural interface is presented based on organic‐electrochemical‐transistor‐(OECT)‐based network, with capabilities of continuous high‐fidelity mapping of neural signals and biosafety active degrading after performing functions. Such platform yields a high spatiotemporal resolution of 1.42 ms and 20 µm, with signal‐to‐noise ratio up to ≈37 dB. The implantable OECT arrays can well establish stable functional neural interfaces, designed as fully biodegradable electronic platforms in vivo. Demonstrated applications of such OECT implants include real‐time monitoring of electrical activities from the cortical surface of rats under various conditions (e.g., narcosis, epileptic seizure, and electric stimuli) and electrocorticography mapping from 100 channels. This technology offers general applicability in neural interfaces, with great potential utility in treatment/diagnosis of neurological disorders.

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Section: In Vivo Characterizationsupporting

confidence: 78%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ultrathin, Soft, Bioresorbable Organic Electrochemical Transistors for Transient Spatiotemporal Mapping of Brain Activity

Yao

Huang

et al. 2023

Advanced Science

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“…We have previously demonstrated the MMAD’s capability of electrical stimulation (Devon J Griggs et al ., 2021; Khateeb et al ., 2022; Zhou et al ., 2022, 2023; Schwock et al ., 2024), which opens further experimental opportunities, especially given that optogenetic and electrical stimulation have been shown to work synergistically (Ohayon et al ., 2013; Hart et al ., 2020). Furthermore, we predict our work will spur the development of MMADs with higher channel counts of smaller and transparent electrodes to increase electrophysiological resolution and optical access (Belloir et al ., 2022; Vargo et al ., 2023). We also expect LEDs will be incorporated into future MMAD designs, much like past work with electrodes arrays (e.g., (Ji et al ., 2018; Reddy et al ., 2019)).…”

Section: Discussionmentioning

confidence: 95%

A large-scale optogenetic neurophysiology platform for improving accessibility in NHP behavioral experiments

Griggs,

Bloch,

Stanis

et al. 2024

Preprint

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Optogenetics has been a powerful scientific tool for two decades, yet its integration with non-human primate (NHP) electrophysiology has been limited due to several technical challenges. These include a lack of electrode arrays capable of supporting large-scale and long-term optical access, inaccessible viral vector delivery methods for transfection of large regions of cortex, a paucity of hardware designed for large-scale patterned cortical illumination, and inflexible designs for multi-modal experimentation. To address these gaps, we introduce a highly accessible platform integrating optogenetics and electrophysiology for behavioral and neural modulation with neurophysiological recording in NHPs. We employed this platform in two rhesus macaques and showcased its capability of optogenetically disrupting reaches, while simultaneously monitoring ongoing electrocorticography activity underlying the stimulation-induced behavioral changes. The platform exhibits long-term stability and functionality, thereby facilitating large-scale electrophysiology, optical imaging, and optogenetics over months, which is crucial for translationally relevant multi-modal studies of neurological and neuropsychiatric disorders.Graphical Abstract

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“…For example, electrical stimulation administered during the acute phase of ischemic stroke using this system proved to reduce lesion volume. 12 Furthermore, the optical access provided through this interface enables optical stimulation (e.g., optogenetics) 1 , 2 , 4 , 6 , 7 , 13 , 14 , 15 , 16 , 17 , 18 , 19 in addition to electrical stimulation for more sophisticated manipulation of the network. Previous work, using both electrical 20 , 21 , 22 , 23 , 24 , 25 and optogenetic 17 stimulation, has demonstrated the feasibility of perturbing the neural network and establishing precise functional connectivity changes.…”

Section: Before You Beginmentioning

confidence: 99%

Protocol to study ischemic stroke by photothrombotic lesioning in the cortex of non-human primates

Stanis,

Khateeb,

Zhou

et al. 2023

STAR Protocols

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Large-scale multimodal surface neural interfaces for primates

Cited by 4 publications

References 157 publications

Ultrathin, Soft, Bioresorbable Organic Electrochemical Transistors for Transient Spatiotemporal Mapping of Brain Activity

Ultrathin, Soft, Bioresorbable Organic Electrochemical Transistors for Transient Spatiotemporal Mapping of Brain Activity

A large-scale optogenetic neurophysiology platform for improving accessibility in NHP behavioral experiments

Protocol to study ischemic stroke by photothrombotic lesioning in the cortex of non-human primates

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