Large-spot subthreshold transpupillary thermotherapy for chronic serous macular detachment

Giudice, Giuseppe Lo; Belvis, Valentina de; Tavolato, Marco; Galan, Alessandro

doi:10.2147/opth.s16014

Cited by 13 publications

(6 citation statements)

References 31 publications

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“…Only a real-time dosimetry during the photocoagulation can guarantee predictable strength and size of the coagulations, which is expected to make the treatment safer and more reproducible. Especially near and sub-threshold therapy concepts [ 9 , 10 ] would profit from an independent control of the photocoagulation strength. Earlier attempts to use the increase of tissue scattering in the retina [ 11 ] or autofluorescence [ 12 ] were not successful.…”

Section: Introductionmentioning

confidence: 99%

Imaging thermal expansion and retinal tissue changes during photocoagulation by high speed OCT

Müller¹,

Ptaszynski²,

Schlott³

et al. 2012

Biomed. Opt. Express

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Visualizing retinal photocoagulation by real-time OCT measurements may considerably improve the understanding of thermally induced tissue changes and might enable a better reproducibility of the ocular laser treatment. High speed Doppler OCT with 860 frames per second imaged tissue changes in the fundus of enucleated porcine eyes during laser irradiation. Tissue motion, measured by Doppler OCT with nanometer resolution, was correlated with the temperature increase, which was measured non-invasively by optoacoustics. In enucleated eyes, the increase of the OCT signal near the retinal pigment epithelium (RPE) corresponded well to the macroscopically visible whitening of the tissue. At low irradiance, Doppler OCT revealed additionally a reversible thermal expansion of the retina. At higher irradiance additional movement due to irreversible tissue changes was observed. Measurements of the tissue expansion were also possible in vivo in a rabbit with submicrometer resolution when global tissue motion was compensated. Doppler OCT may be used for spatially resolved measurements of retinal temperature increases and thermally induced tissue changes. It can play an important role in understanding the mechanisms of photocoagulation and, eventually, lead to new strategies for retinal laser treatments.

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Section: Introductionmentioning

confidence: 99%

Imaging thermal expansion and retinal tissue changes during photocoagulation by high speed OCT

Müller¹,

Ptaszynski²,

Schlott³

et al. 2012

Biomed. Opt. Express

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“…Локальная гипертермия приводит к каскаду реакций с выработкой белков теплового шока, способных восстанавливать работу ПЭС. Эффективность ТТТ составляет 40-96 % по данным разных исследователей в зависимости от протоколов проводимой термотерапии, разрабатываемых и по сей день [5,[17][18][19][20][21][22].…”

Section: лечение пациентов с цсхunclassified

Current Approach to Treatment for Central Serous Chorioretinopathy. Review

Дракон¹,

Патеюк²,

Sheludchenko³

et al. 2021

Oftalʹmologiâ

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Central serous chorioretinopathy (CSC) is a disease of complex origin and unknown etiology. Traditionally, two clinical forms of CSC are verified in accordance with the activity and duration of the pathological process: classic acute form and chronic CSC. Nowadays, there is no unified concept accepted for the management of patients with this disease, particular difficulties exist in cases of chronic CSC. This literature review highlights current trends and approaches to the treatment of CSC patients — from focal laser photocoagulation to physical methods oh therapy. The therapeutic approach as a whole depends on the form of the CHS. In most cases of the acute form of CSF, spontaneous regression, spontaneous adhesion of RPE detachment and retinal neuroepithelium are noted within several months from the onset of the disease. Therapy for the chronic form of this disease is still a difficult task and a controversial issue. Direct laser coagulation of the retina at the oozing point is recognized as the most effective method of therapy for acute typical form of CSF. In the chronic form of CSC, photodynamic therapy, transpupillary thermotherapy and subthreshold micropulse laser exposure are used. The goal of drug therapy for CSF is to activate the processes of resorption of serous fluid from the subretinal or subpigmented space, reduce the activity of pathological processes in the choroid, and improve trophism and metabolism. The currently used methods of treating chronic CSH have a number of disadvantages and variable efficacy. The existence of treatment-resistant cases is the subject of further research and clinical research. The development of new physical and physiopharmacological methods of treatment for CSF is perspective.

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“…It works by raising the temperature of the choroid and outer retina while sparing the inner retina and photoreceptors to some degree, but the exact mechanism is not clear 61 . First described in 2005 by Wei, short-term encouraging visual and anatomical outcomes have been observed in CSCR with subfoveal leaks, multiple or diffuse leaks, and recurrent atypical CSCR with PEDs 61, 62, 63, 64. More well structured RCTs with long-term results are required to establish the role of TTT in the treatment of CSCR.…”

Section: Treatmentmentioning

confidence: 99%

Advances in the treatment of central serous chorioretinopathy

Abouammoh

2015

Saudi Journal of Ophthalmology

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Central serous chorioretinopathy is a disease that is partly understood. Novel advancements have led to further understanding of the disease, and have identified choroidal dysfunction as the principal element in CSCR development. New imaging tools have aided in better monitoring disease response to various treatment models. Enhanced depth imaging optical coherence tomography, in particular, has helped in observing choroidal thickness changes after various treatment models. To date, photodynamic therapy and focal laser remain the main stay of treatment. More understanding of disease pathophysiology in the future will help in determining the drug of choice and the best management option for such cases.

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Large-spot subthreshold transpupillary thermotherapy for chronic serous macular detachment

Cited by 13 publications

References 31 publications

Imaging thermal expansion and retinal tissue changes during photocoagulation by high speed OCT

Imaging thermal expansion and retinal tissue changes during photocoagulation by high speed OCT

Current Approach to Treatment for Central Serous Chorioretinopathy. Review

Advances in the treatment of central serous chorioretinopathy

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