Large-volume multi-tined expandable RF ablation in pig livers: comparison of 2D and volumetric measurements of the ablation zone

Bangard, Christopher; Rösgen, S.; Wahba, Roger; Wiemker, Rafael; Hellmich, Martin; Reiter, Hannah; Fischer, J.; Stippel, Dirk L.; Lackner, K.

doi:10.1007/s00330-009-1639-4

Cited by 9 publications

(4 citation statements)

References 22 publications

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“…This study’s results showed that the diameter-derived sphere volume was larger than the tumor volume on the basis of the assumption of rotational symmetry, which was consistent with prior findings in experimental and clinical animal studies. 37 , 38 , 39 Consequently, the spherical cut-points may facilitate the re-identification in patient subgroups that possibly benefit from locoregional or salvage therapies. 34 , 38 …”

Section: Discussionmentioning

confidence: 99%

Comparison of quantitative volumetric analysis and linear measurement for predicting the survival of Barcelona Clinic Liver Cancer 0- and A stage hepatocellular carcinoma after radiofrequency ablation

Yang¹,

Zhang²,

Su³

et al. 2023

dir

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PURPOSE The prognostic role of the tumor volume in patients with hepatocellular carcinoma (HCC) at the Barcelona Clinic Liver Cancer (BCLC) 0 and A stages remains unclear. This study aims to compare the volumetric measurement with linear measurement in early HCC burden profile and clarify the optimal cut-off value of the tumor volume. METHODS The consecutive patients diagnosed with HCC who underwent initial and curative-intent radiofrequency ablation (RFA) were included retrospectively. The segmentation was performed semi-automatically, and enhanced tumor volume (ETV) as well as total tumor volume (TTV) were obtained. The patients were categorized into high- and low-tumor burden groups according to various cutoff values derived from commonly used diameter values, X-tile software, and decision-tree analysis. The inter- and intra-reviewer agreements were measured using the intra-class correlation coefficient. Univariate and multivariate time-to-event Cox regression analyses were performed to identify the prognostic factors of overall survival. RESULTS A total of 73 patients with 81 lesions were analyzed in the whole cohort with a median follow-up of 31.0 (interquartile range: 16.0–36.3). In tumor segmentation, excellent consistency was observed in intra- and inter-reviewer assessments. There was a strong correlation between diameter-derived spherical volume and ETV as well as ETV and TTV. As opposed to all linear candidates and 4,188 mm 3 (sphere equivalent to 2 cm in diameter), ETV >14,137 mm 3 (sphere equivalent to 3 cm in diameter) or 23,000 mm 3 (sphere equivalent to 3.5 cm in diameter) was identified as an independent risk factor of survival. Considering the value of hazard ratio and convenience to use, when ETV was at 23,000 mm 3 , it was regarded as the optimal volumetric cut-off value in differentiating survival risk. CONCLUSION The volumetric measurement outperforms linear measurement on tumor burden evaluation for survival stratification in patients at BCLC 0 and A stages HCC after RFA.

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Section: Discussionmentioning

confidence: 99%

Comparison of quantitative volumetric analysis and linear measurement for predicting the survival of Barcelona Clinic Liver Cancer 0- and A stage hepatocellular carcinoma after radiofrequency ablation

Yang¹,

Zhang²,

Su³

et al. 2023

dir

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“…Multiplanar imaging has been found to be helpful for assessing the ablation zone in the postprocedural setting. A recent study demonstrated that 2D imaging of the ablation zone in porcine livers may underestimate its size, and that 3D imaging with volumetric measurements may be of benefit [25]. This ability improves accuracy and allows the operator to ablate, in the same session, areas that may not have the desired ‘ablation margin’.…”

Section: Imaging Hccsmentioning

confidence: 99%

Imaging to optimize liver tumor ablation

Pua

Sofocleous

2010

Imaging in Medicine

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Surgical resection remains the ideal treatment for hepatocellular carcinoma and metastasis to the liver. Many alternatives are available for treatment of nonsurgical candidates. Regardless of treatment, optimizing imaging in the pretreatment, treatment and post-treatment settings is critical in order to lower the rates of local tumor progression and maximize the effectiveness of treatment that may result in prolonged survival. This article summarizes some basic imaging techniques of primary and metastatic liver tumors with a focus on how to optimize their treatment with ablation.

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“…Für eine niedrige Lokalrezidivrate ist die genaue Kenntnis der durch das ausgewählte RFA-System induzierten Nekrose wichtig. Die Größen und Formen der induzierten Nekrosen unterscheiden sich wesentlich und müssen für die Platzierung des Applikators berücksichtigt werden [14,15]. Hierbei täuschen einzelne zweidimensionale Schnitte ein größeres therapeutisch nutzbares Volumen vor, als es sich in volumetrischen dreidimensionalen Analysen ergibt.…”

Section: Stippelunclassified

Neuroendokrine Tumoren: Lokal ablative Verfahren – RFA, LITT, Alkoholinjektion, Kryoablation

Stippel¹

2010

Viszeralmedizin

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Neuroendokrine Tumoren sind eine seltene, heterogene Tumorentität, bei der sich die Hälfte der Patienten mit Lebermetastasen präsentiert. Aufgrund des häufig dominanten Leberbefalls und des langsamen Wachstums kommen lokal ablative Verfahren in Betracht. Die Radiofrequenzablation und die laserinduzierte Thermotherapie haben die perkutane Ethanol-Injektion und die Kryoablation aufgrund von Daten bei anderen Tumorentitäten auch in dieser Indikation wegen der überlegenen Tumorkontrolle und Sicherheit weitgehend abgelöst. Die Datenlage zu Patienten mit neuroendokrinen Lebermetastasen ist jedoch auf einzelne Serien mit jeweils weniger als 63 Patienten beschränkt. Als Indikationen bestehen die Erweiterung der Indikation zur Resektion mit kurativem Ansatz durch Ablation kleiner nichtresektabler Metastasen, die Zytoreduktion mit dem Debulking von >90% der Tumormasse und die palliative Indikation bei Patienten mit Symptomen durch eine endokrine Sekretion der Lebermetastasen. In 95% gelingt die lokale Tumorkontrolle bei Anwendung von State-of-the-art-Ablations systemen bei Metastasen bis 3 cm Durchmesser. Die Prognose bezüglich eines intra- und extrahepatischen Rezidivs korreliert wesentlich mit biologischen Faktoren des neuroendokrinen Tumors (Ki67, Serum-Chromogranin A).

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Large-volume multi-tined expandable RF ablation in pig livers: comparison of 2D and volumetric measurements of the ablation zone

Abstract: Two-dimensional CT measurements assuming rotational symmetry of the AZ overestimate the largest ablated sphere centred on the electrode shaft compared with 3D CT measurements.

Cited by 9 publications

References 22 publications

Comparison of quantitative volumetric analysis and linear measurement for predicting the survival of Barcelona Clinic Liver Cancer 0- and A stage hepatocellular carcinoma after radiofrequency ablation

Comparison of quantitative volumetric analysis and linear measurement for predicting the survival of Barcelona Clinic Liver Cancer 0- and A stage hepatocellular carcinoma after radiofrequency ablation

Imaging to optimize liver tumor ablation

Neuroendokrine Tumoren: Lokal ablative Verfahren – RFA, LITT, Alkoholinjektion, Kryoablation

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