Largest Phyllodes Tumor- Case Report and Brief Review Article

Abstract

This is an article reporting the largest phyllodes tumor and the role of radiotherapy in patients of phyllodes tumor of breast, based on Medline search for articles in English language using keywords "role of radiotherapy in phyllodes tumor of breast". 32 years female presented with a lump in right breast since last 4 months. This was the second recurrence of similar lump in last 6 years. Biopsy from the lump proved to be cystosarcoma phyllodes. Radical Mastectomy with level I node sampling and reconstruction with Latissimus Dorsi Myocutaneous flap was done as a curative procedure. The tumor measured exactly to be 50×25.2×16.4 cm in size and 15 kg in weight. Proliferation markers like Ki-67 and p53 were in the range of 1-2% and 3-4% respectively. Histopathological diagnosis of the tumor was borderline phyllodes tumor. Patient had an uneventful postoperative course and is presently on three monthly follow up since 1 year.

Malignant phyllodes tumor of the breast presenting with hypoglycemia: a case report and literature review

“…Radiotherapy may have a role in the treatment of PT depending on the number of recurrences, mitotic index, bulky tumor, status of resection margins, and p53 and Ki67 expression. 20 Adjuvant radiation therapy has been recommended for malignant PTs in the belief that this should be managed as a soft tissue sarcoma with resection and to reduce the risk of local recurrence. Some authors recommend radiation therapy for patients with positive surgical margins, tumor size >5 cm, and for patients who received lumpectomy for primary treatment.…”

Recurrent phyllodes tumor of the breast transforming to a fibrosarcoma

“…Phyllodes tumor is the currently accepted nomenclature according to the World Health Organization.' 5 Phyllodes tumors are fibroepithelial tumors of the breast, representing 2-3% of all fibroepithelial tumors, and <1% of all breast tumors. 6 Phyllodes tumors are uniquely found in breast tissue and histologically have both an epithelial component as well as metaplastic mesenchymal (stromal) component.…”

Phyllodes tumor in pregnancy: A Case Report

“…Malignant tumors usually have rhabdomyosarcoma and liposarcoma rather than fibrosarcomas, the number of mitoses is of great help in the diagnosing the malignant subtype [2][3][4].…”