Larval amphibians rapidly bioaccumulate poly- and perfluoroalkyl substances

Abercrombie, Sarah A.; Perre, Chloé de; Choi, Youn Jeong; Tornabene, Brian J.; Sepúlveda, Marı́a S.; Lee, Linda; Hoverman, Jason T.

doi:10.1016/j.ecoenv.2019.04.022

Cited by 40 publications

(33 citation statements)

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“…Comparisons for other chemicals are limited by lack of measurements. Within a study, most often, lower concentrations provide higher measured BCFs, for example, PFOS with 3 amphibian species (Abercrombie et al 2019), 4 of 7 PFAS chemicals with common carp (Inoue et al 2012), 16 of 21 chemicals with zebrafish (Chen et al 2016), and for exposures of 6 PFAS at concentrations of 1, 5 and 10 μg/L to Daphnia magna , 15 of 18 comparisons (Dai et al 2013). Cause(s) of the decrease in BCFs with higher concentrations are unknown.…”

Section: Resultsmentioning

confidence: 99%

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Evaluation of Published Bioconcentration Factor (BCF) and Bioaccumulation Factor (BAF) Data for Per‐ and Polyfluoroalkyl Substances Across Aquatic Species

Burkhard

2021

Enviro Toxic and Chemistry

128

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Perand polyfluoroalkyl substances (PFAS) are a group of man-made chemicals of concern across the globe, and some of the PFAS chemicals are known to be bioaccumulative in aquatic species. A literature search for bioconcentration factors (BCFs) and bioaccumulation factors (BAFs) for PFASs has been done and data for 22 taxonomic classes were assembled. The assembled data were evaluated for quality, and for gaps and limitations in bioaccumulation information for PFAS universe of chemicals.In general, carbonyl and sulfonyl PFAS classes are relatively data rich while phosphate, fluorotelomer and ether PFAS classes are data limited for fish and nonexistent for most This article is protected by copyright. All rights reserved. Accepted Articleother taxonomic classes. Taxonomic classes with the most measurements were, in descending order, Teleostei (fish), Bivalvia, and Malacostraca. For fish, median whole body log BAFs (L/kg-ww) for perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) were 3.47 (sd=0.78, n=105) and 2.16 (sd=0.85, n=48) using all measurements, respectively. In comparison to freshwater species, data are limited for marine species and further research is needed to determine if BAFs for freshwater and marine species should be the same or different. BAFs for some PFASs appear consistent with BCFs developed with laboratory experiments, in which values decline with increasing concentrations in water.

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Section: Resultsmentioning

confidence: 99%

“…Comparisons for other chemicals are limited by lack of measurements. Within a study, most often, lower concentrations provide higher measured BCFs, e.g., PFOS with three amphibian species(Abercrombie et al 2019), 4 of 7 PFAS…”

mentioning

confidence: 99%

Evaluation of Published Bioconcentration Factor (BCF) and Bioaccumulation Factor (BAF) Data for Per‐ and Polyfluoroalkyl Substances Across Aquatic Species

Burkhard

2021

Enviro Toxic and Chemistry

128

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“…In amphibians (Rana pipiens, Anaxyrus americanus, and Ambystoma tigrinum) BCF value observed for PFOS (BCFs = 47-259) was greater than that recorded for PFOA (BCFs = 0.46-2.5) [89]. Similarly, in tadpoles of R. pipiens exposed for 40 days to three different concentrations of PFOS, PFHxS, PFOA, and 6:2 fluorotelomer sulfonate (6:2 FTS) the PFOS, showed higher accumulated levels with BCF ranging from 19.6 to 119.3 while other PFAS had BCF < 1.0 [66].…”

Section: Pfas Uptake Under Controlled Experimental Conditionsmentioning

confidence: 65%

Bioaccumulation, Biodistribution, Toxicology and Biomonitoring of Organofluorine Compounds in Aquatic Organisms

Savoca

Pace

2021

IJMS

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This review is a survey of recent advances in studies concerning the impact of poly- and perfluorinated organic compounds in aquatic organisms. After a brief introduction on poly- and perfluorinated compounds (PFCs) features, an overview of recent monitoring studies is reported illustrating ranges of recorded concentrations in water, sediments, and species. Besides presenting general concepts defining bioaccumulative potential and its indicators, the biodistribution of PFCs is described taking in consideration different tissues/organs of the investigated species as well as differences between studies in the wild or under controlled laboratory conditions. The potential use of species as bioindicators for biomonitoring studies are discussed and data are summarized in a table reporting the number of monitored PFCs and their total concentration as a function of investigated species. Moreover, biomolecular effects on taxonomically different species are illustrated. In the final paragraph, main findings have been summarized and possible solutions to environmental threats posed by PFCs in the aquatic environment are discussed.

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“…Toads were much smaller; thus, whole bodies were extracted with no need for subsampling. Salamanders were too large to homogenize, so whole livers were extracted instead, except for 8000‐ppb PFOS exposures, where liver subsamples were used because of the very high concentrations expected (Martin et al 2009; Ulhaq et al 2015; Cui et al 2018) based on known bioaccumulation factors (Abercrombie et al 2019). We confirmed homogeneity of tiger salamander livers by sectioning a liver into 11 parts (Supplemental Data, Figure S1) and extracted and analyzed each section separately.…”

Section: Methodsmentioning

confidence: 99%

Sublethal Effects of Dermal Exposure to Poly‐ and Perfluoroalkyl Substances on Postmetamorphic Amphibians

Abercrombie

Perre

Iacchetta

et al. 2020

Enviro Toxic and Chemistry

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Studies of the toxicity of poly‐ and perfluoroalkyl substances (PFAS) on amphibians, especially after metamorphosis, are limited. We examined effects of dermal PFAS exposure (30 d) on survival and growth of juvenile American toads (Anaxyrus americanus), eastern tiger salamanders (Ambystoma tigrinum), and northern leopard frogs (Rana pipiens). Chemicals included perfluorooctanoic acid, perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate (PFHxS), and 6:2 fluorotelomer sulfonate (6:2 FTS) at 0, 80, 800, or 8000 ppb on a moss dry weight basis. Exposure to PFAS influenced final snout–vent length (SVL) and scaled mass index (SMI), a measure of relative body condition. Observed effects depended on species and chemical, but not concentration. Anurans exposed to PFOS, PFHxS (frogs only), and 6:2 FTS demonstrated reduced SVL versus controls, whereas salamanders exposed to 6:2 FTS showed increased SVL. Frogs exposed to PFHxS and 6:2 FTS and toads exposed to PFOS had increased SMI compared to controls; salamanders did not demonstrate effects. Concentrations of 6:2 FTS in substrate decreased substantially by 30 d, likely driven by microbial action. Perfluorooctane sulfonate had notable biota–sediment accumulation factors, but was still <1. Although a no‐observable‐effect concentration could not generally be determined, the lowest‐observable‐effect concentration was 50 to 120 ppb. Survival was not affected. The present study demonstrates that PFAS bioaccumulation from dermal exposures and sublethal effects are dependent on species, chemical, and focal trait. Environ Toxicol Chem 2021;40:717–726. © 2020 SETAC

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Larval amphibians rapidly bioaccumulate poly- and perfluoroalkyl substances

Cited by 40 publications

References 50 publications

Evaluation of Published Bioconcentration Factor (BCF) and Bioaccumulation Factor (BAF) Data for Per‐ and Polyfluoroalkyl Substances Across Aquatic Species

Evaluation of Published Bioconcentration Factor (BCF) and Bioaccumulation Factor (BAF) Data for Per‐ and Polyfluoroalkyl Substances Across Aquatic Species

Bioaccumulation, Biodistribution, Toxicology and Biomonitoring of Organofluorine Compounds in Aquatic Organisms

Sublethal Effects of Dermal Exposure to Poly‐ and Perfluoroalkyl Substances on Postmetamorphic Amphibians

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