Larvicidal activities of the stem bark extract and rotenoids of Millettia usaramensis subspecies usaramensis on Aedes aegypti L. (Diptera: Culicidae)

Bosire, Carren M.; Deyou, Tsegaye; Kabaru, J. M.; Kimata, Dennis M.; Yenesew, Abiy

doi:10.1016/j.aspen.2014.05.003

Cited by 8 publications

(5 citation statements)

References 19 publications

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“…Moreover, reports of resistance in different areas worldwide have discouraged their use and stimulated efforts to search for new compounds to control this vector . Among new alternatives, many plant compounds such as proteins or secondary metabolites show insecticidal activities on one or more stages of development of this mosquito . There are many reports supporting the use of these new molecules in view of their high degradability, low production cost and different mechanisms of action on insect development stages .…”

Section: Introductionmentioning

confidence: 99%

Trypsin inhibitor fromLeucaena leucocephalaseeds delays and disrupts the development ofAedes aegypti,a multiple-disease vector

et al. 2016

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Section: Introductionmentioning

confidence: 99%

Trypsin inhibitor fromLeucaena leucocephalaseeds delays and disrupts the development ofAedes aegypti,a multiple-disease vector

et al. 2016

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“…Medicinal plants represent the largest sources of phytochemicals, showing various biological activities, such as antimicrobial (Dhale & Birari, 2010), antifungal , antimalarial (Jansen et al, 2010) and bioinsecticidal effects (Bosire, Deyou, Kabaru, Kimata, & Yenesew, 2014).…”

Section: Introductionmentioning

confidence: 99%

<b>Larvicidal, cytotoxic and genotoxic effects of aqueous leaf extract of <i>Jatropha mollissima</i> (Pohl) Baill

Araujo

Costa

Oliveira

et al. 2018

Acta Sci. Biol. Sci.

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ABSTRACT. The present study aimed to evaluate the larvicidal effect of aqueous leaf extract from Jatropha mollissima on the larvae of Aedes aegypti and analyze its cytotoxic and genotoxic activity in the Allium cepa test. Larvae of the mosquito were exposed to the negative and positive controls (distilled water and diflubenzuron, 0.003 mg mL -1 , respectively) and to leaf extract concentrations of 0.001, 0.005, 0.01, 0.02, 0.04, 0.06, 0.08 and 0.1 mg mL -1 . The mortality rate was evaluated every 24 hours over five days. For the cytotoxic and genotoxic analyses, roots of A. cepa were exposed to the negative (distilled water) and positive control (trifluralin, 0.84 ppm) and to different leaf extract concentrations (0.01, 0.1, 1 and 10 mg mL Efeitos larvicida, citotóxico e genotóxico do extrato aquoso das folhas de Jatropha mollissima (Pohl) Baill RESUMO. O presente estudo teve como objetivo avaliar o efeito larvicida do extrato aquoso das folhas de Jatropha mollissima sobre as larvas de Aedes aegypti e analisar sua atividade citotóxica e genotóxica no teste Allium cepa. As larvas do mosquito foram expostas aos controles negativo e positivo (água destilada e diflubenzuron, 0,003 mg mL -1 , respectivamente) e ao extrato foliar nas concentrações de 0,001; 0,005; 0,01; 0,02; 0,04; 0,06; 0,08 e 0,1 mg mL -1 . A taxa de mortalidade foi avaliada a cada 24horas durante cinco dias. Para as análises citotóxica e genotóxica, as raízes de A. cepa foram expostas ao controle negativo (água destilada) e positivo (trifluralina, 0,84 ppm) e nas concentrações (0,01; 0,1; 1 e 10 mg mL -1 ) do extrato foliar por 24 horas. Análises estatísticas foram realizadas pelo teste de Kruskal-Wallis (p < 0,05). O extrato foliar apresentou atividade larvicida promissora nas concentrações de 0,08 e 0,1 mg mL -1 , e nenhuma das concentrações avaliadas em A. cepa exibiu efeito citotóxico ou genotóxico. Uma vez demonstrada a ação larvicida de J. mollissima e a ausência de toxicidade celular, mais estudos são recomendados para determinar o mecanismo de ação do extrato como um possível larvicida natural.

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“…Medicinal plants, the most common source of phytochemicals, exhibit a number of biological activities, such as antimicrobial, antifungal (Nguta et al, 2016), antimalarial (Kiraithe, Nguta, Mbaria, & Kiama, 2016) and bioinsecticidal (Bosire, Deyou, Kabaru, Kimata, & Yenesew, 2014). Pharmacological screening, isolation and characterization of bioactive compounds, as well as toxicological and clinical assessment are essential to guarantee their effectiveness and determine their pharmacokinetics, bioavailability, safety and drug interactions (Sasidharan, Chen, Saravanan, Sundram, & Latha, 2011).…”

Section: Introductionmentioning

confidence: 99%

Modulating effect of Poincianella bracteosa (Tul.) L.P. Queiroz bark (Leguminosae) on DNA damage induced by doxorubicin on the somatic cells of Drosophila melanogaster wings

Oliveira

Moura

Sousa

et al. 2020

RSD

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The aim of this study was to assess the genotoxic and antigenotoxic effects of Poincianella bracteosa bark aqueous extract on DNA damage induced by doxorubicin (DXR) a chemotherapeutic agent using SMART (Somatic Mutation and Recombination Test). The analysis was performed using the somatic mutation and recombination test in Drosophila melanogaster. Larvae from the standard and high-bioactivity crosses were chronically treated with four concentrations of P. bracteosa bark tea, alone and in association with DXR. The results revealed no mutagenic effect of bark extract for any of the concentrations tested. A modulating effect of aqueous extract in reducing the genotoxic action of DXR was observed for all concentrations tested in descendants of both crosses, but inhibition was more effective in those from the high-bioactive cross. The modulating effect observed may be associated with the presence of tannins and reducing sugars, as observed in phytochemical studies, since they are capable of capturing and stabilizing free radicals. Given the widespread use of P. bracteosa bark in folk medicine, further studies to elucidate the mechanism of action of these cellular compounds and with other experimental models would be useful to confirm that P. bracteosa extract is beneficial to human health.

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Larvicidal activities of the stem bark extract and rotenoids of Millettia usaramensis subspecies usaramensis on Aedes aegypti L. (Diptera: Culicidae)

Cited by 8 publications

References 19 publications

Trypsin inhibitor fromLeucaena leucocephalaseeds delays and disrupts the development ofAedes aegypti,a multiple-disease vector

Trypsin inhibitor fromLeucaena leucocephalaseeds delays and disrupts the development ofAedes aegypti,a multiple-disease vector

<b>Larvicidal, cytotoxic and genotoxic effects of aqueous leaf extract of <i>Jatropha mollissima</i> (Pohl) Baill

Modulating effect of Poincianella bracteosa (Tul.) L.P. Queiroz bark (Leguminosae) on DNA damage induced by doxorubicin on the somatic cells of Drosophila melanogaster wings

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