Larvicidal activity of natural and modified triterpenoids against <i>Aedes aegypti</i> (Diptera: Culicidae)

Silva, Gloria N.S. da; Trindade, Frances Tatiane Tavares; Santos, Francine dos; Gosmann, Grace; Silva, Alexandre A. e; Gnoatto, Simone Cristina Baggio

doi:10.1002/ps.4221

Cited by 27 publications

(14 citation statements)

References 25 publications

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“…The eggs were allowed to hatch in an enamel bowl lined with Whatman filter paper filled with distilled water. The pupae formed were separated and transferred to insectary for the emergence of adults (da Silva et al, 2016[6]).…”

Section: Methodsmentioning

confidence: 99%

Isolation and characterization of phthalates from Brevibacterium mcbrellneri that cause cytotoxicity and cell cycle arrest

Rajamanikyam

Vadlapudi

Parvathaneni

et al. 2017

EXCLI Journal; 16:Doc375; ISSN 1611-2156

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Section: Methodsmentioning

confidence: 99%

Isolation and characterization of phthalates from Brevibacterium mcbrellneri that cause cytotoxicity and cell cycle arrest

Rajamanikyam

Vadlapudi

Parvathaneni

et al. 2017

EXCLI Journal; 16:Doc375; ISSN 1611-2156

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“…Their corresponding structures are illustrated in Figure 5. Bioassays of their chemical derivatives, with esterification of the hydroxyl group at the C-3 position, demonstrated less activity, suggesting that the hydroxyl group plays an important role in larvicidal activity [126].…”

Section: Terpenesmentioning

confidence: 99%

Plant Natural Products for the Control of Aedes aegypti: The Main Vector of Important Arboviruses

et al. 2020

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The mosquito species Aedes aegypti is one of the main vectors of arboviruses, including dengue, Zika and chikungunya. Considering the deficiency or absence of vaccines to prevent these diseases, vector control remains an important strategy. The use of plant natural product-based insecticides constitutes an alternative to chemical insecticides as they are degraded more easily and are less harmful to the environment, not to mention their lower toxicity to non-target insects. This review details plant species and their secondary metabolites that have demonstrated insecticidal properties (ovicidal, larvicidal, pupicidal, adulticidal, repellent and ovipositional effects) against the mosquito, together with their mechanisms of action. In particular, essential oils and some of their chemical constituents such as terpenoids and phenylpropanoids offer distinct advantages. Thiophenes, amides and alkaloids also possess high larvicidal and adulticidal activities, adding to the wealth of plant natural products with potential in vector control applications.

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“…Molecular modeling techniques were also applied to establish a quantitative structure-activity relationship (QSAR). 57,[67][68][69][70] Structure-activity relationship studies were performed for acetogenins emphasizing the inhibition of the mitochondrial I complex. Data revealed that the presence of 1 or 2 tetrahydrofuran (THF) rings would have similar inhibitory effect.…”

Section: Structure-activity Relationshipmentioning

confidence: 99%

“…69 Larvicidal activity observed for both betulinic and ursolic triterpenic acids revealed that the presence of the hydroxyl group in C-3 is fundamental, as the esterification of hydroxyl decreases this activity. 57 By using QSAR method, a study was recently carried out, specifically for 61 plant-derived compounds known to have A. aegypti larvicidal activity. Compounds of the terpene class, phenylpropanoids, ketones, and oxygenate compounds were selected for the study.…”

Section: Structure-activity Relationshipmentioning

confidence: 99%

Larvicidal Activity of Secondary Plant Metabolites in Aedes aegypti Control: An Overview of the Previous 6 Years

Wuillda

Martins

Costa

2019

Natural Product Communications

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Aedes aegypti is the main transmitter of several arboviruses, mainly dengue. It occurs, recently, in more than 100 countries and majority of the world population lives in areas of mosquito incidence, marking its control relevant and necessary. Presently, the main form of vector control is the use of synthetic insecticides; however, its continuous application has led to inefficiency due to resistance development. Based on this fact, the insecticides from natural sources appear as a friendly alternative for man and the environment. This study provides an overview of the larvicidal compounds isolated from plant extracts while controlling A. aegypti, in the previous 6 years (2013-2018), and aims to impart more knowledge regarding the described metabolites and to encourage the search for new bioactive compounds. In addition, the proposals for mechanisms of action and structure-activity relationships that may justify the larvicidal potential are also discussed.

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Larvicidal activity of natural and modified triterpenoids against Aedes aegypti (Diptera: Culicidae)

Abstract: BA, UA and their derivatives showed larvicidal activity against Ae. aegypti larvae, increasing significantly from 48 to 96 h. The presence of a hydroxyl group is essential for larvicidal potential in these triterpenoids. © 2016 Society of Chemical Industry.

Cited by 27 publications

References 25 publications

Isolation and characterization of phthalates from Brevibacterium mcbrellneri that cause cytotoxicity and cell cycle arrest

Isolation and characterization of phthalates from Brevibacterium mcbrellneri that cause cytotoxicity and cell cycle arrest

Plant Natural Products for the Control of Aedes aegypti: The Main Vector of Important Arboviruses

Larvicidal Activity of Secondary Plant Metabolites in Aedes aegypti Control: An Overview of the Previous 6 Years

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