Larvicide Activity on Aedes aegypti of Essential Oil Nanoemulsion from the Protium heptaphyllum Resin

Faustino, Cleidjane Gomes; Medeiros, Fernando Antônio de; Galardo, Allan Kardec Ribeiro; Rodrigues, Alex Bruno Lobato; Martins, Rosany Lopes; Lima, Yuri de Medeiros Souza; Tavares, Josean Fechine; Medeiros, Marcos Antônio Alves de; Cruz, Jader Dos Santos; Almeida, Sheylla Susan Moreira da Silva de

doi:10.3390/molecules25225333

Cited by 18 publications

(13 citation statements)

References 31 publications

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“…Essential oils are volatile and contain several chemical compounds, which individually or together have insecticidal activity. The chemical composition of the essential oil of the P. heptaphyllum resin presented p-cymene (27.70%) and α-pinene (22.31%) as major constituents, but in this analysis, all minor and major constituents were identified [10], which corroborates with the data found in the literature concerning the specific chemical [13].…”

Section: The Chemical Composition and Nanoemulsion Stability Of The Essential Oilsupporting

confidence: 90%

“…Nanoemulsions are kinetically stable colloidal systems of two immiscible liquids stabilized by surfactants. Thus, the nanoemulsion loaded with the P. heptaphyllum resin essential oil presented no obvious signs of microscopic or macroscopic instability in the evaluated time [10]. Several methods have been used to combat A. aegypti; the application of chemical substances to control its life cycle is one of them.…”

Section: The Chemical Composition and Nanoemulsion Stability Of The Essential Oilmentioning

confidence: 99%

“…The nanoemulsion of the essential oil from the resin was prepared by phase inversion without heating, following the titration method [26]. The formulation can be seen with details in our previous publication [10], as well as the characterization through the physical-chemical evaluation of the particle size, polydispersity index and zeta potential (Malvern, UK).…”

Section: Preparation and Characterization Of The Nanoemulsionmentioning

confidence: 99%

“…Thus, the objectives of this study are to evaluate biocidal activities including ovicide, pupicide, adulticide and repellency against the A. aegypti mosquito [10].…”

Section: Introductionmentioning

confidence: 99%

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Biocidal Activity of a Nanoemulsion Containing Essential Oil from Protium heptaphyllum Resin against Aedes aegypti (Diptera: Culicidae)

et al. 2021

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This work aimed to prepare a nanoemulsion containing the essential oil of the Protium heptaphyllum resin and evaluate its biocidal activities against the different stages of development of the Aedes aegypti mosquito. Ovicide, pupicide, adulticide and repellency assays were performed. The main constituents were p-cymene (27.70%) and α-pinene (22.31%). The developed nanoemulsion showed kinetic stability and monomodal distribution at a hydrophilic–lipophilic balance of 14 with a droplet size of 115.56 ± 1.68 nn and a zeta potential of −29.63 ± 3.46 mV. The nanoemulsion showed insecticidal action with LC50 0.404 µg.mL−1 for the ovicidal effect. In the pupicidal test, at the concentration of 160 µg.mL−1, 100% mortality was reached after 24 h. For adulticidal activity, a diagnostic concentration of 200 µg.mL−1 (120 min) was determined. In the repellency test, a concentration of 200 µg.mL−1 during the 180 min of the test showed a protection index of 77.67%. In conclusion, the nanobiotechnological product derived from the essential oil of P.heptaphyllumresin can be considered as a promising colloid that can be used to control infectious disease vectors through a wide range of possible modes of applications, probably as this bioactive delivery system may allow the optimal effect of the P. heptaphyllum terpenes in aqueous media and may also induce satisfactory delivery to air interfaces.

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Section: The Chemical Composition and Nanoemulsion Stability Of The Essential Oilsupporting

confidence: 90%

Section: The Chemical Composition and Nanoemulsion Stability Of The Essential Oilmentioning

confidence: 99%

Section: Preparation and Characterization Of The Nanoemulsionmentioning

confidence: 99%

“…Thus, the objectives of this study are to evaluate biocidal activities including ovicide, pupicide, adulticide and repellency against the A. aegypti mosquito [10].…”

Section: Introductionmentioning

confidence: 99%

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Biocidal Activity of a Nanoemulsion Containing Essential Oil from Protium heptaphyllum Resin against Aedes aegypti (Diptera: Culicidae)

et al. 2021

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“…However, the mechanisms involved in the observed anti-inflammatory action were not clarified. More recently, antibacterial activity [ 36 , 37 , 38 ] and effects on blood sugar level and lipid profile have also been highlighted for the essential oil obtained from P. heptaphyllum gum resin [ 39 , 40 , 41 ]. The observed effects on lipid metabolism involved a decrease of total cholesterol, LDL-C, serum triglycerides, and VLDL, with an elevation of high-density lipoprotein cholesterol (HDL-C).…”

Section: Introductionmentioning

confidence: 99%

Bioactive Triterpenes of Protium heptaphyllum Gum Resin Extract Display Cholesterol-Lowering Potential

Mannino

Iovino²,

Lauria

et al. 2021

IJMS

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Hypercholesterolemia is one of the major causes of cardiovascular disease, the risk of which is further increased if other forms of dyslipidemia occur. Current therapeutic strategies include changes in lifestyle coupled with drug administration. Statins represent the most common therapeutic approach, but they may be insufficient due to the onset of resistance mechanisms and side effects. Consequently, patients with mild hypercholesterolemia prefer the use of food supplements since these are perceived to be safer. Here, we investigate the phytochemical profile and cholesterol-lowering potential of Protium heptaphyllum gum resin extract (PHE). Chemical characterization via HPLC-APCI-HRMS2 and GC-FID/MS identified 13 compounds mainly belonging to ursane, oleanane, and tirucallane groups. Studies on human hepatocytes have revealed how PHE is able to reduce cholesterol production and regulate the expression of proteins involved in its metabolism. (HMGCR, PCSK9, LDLR, FXR, IDOL, and PPAR). Moreover, measuring the inhibitory activity of PHE against HMGR, moderate inhibition was recorded. Finally, molecular docking studies identified acidic tetra- and pentacyclic triterpenoids as the main compounds responsible for this action. In conclusion, our study demonstrates how PHE may be a useful alternative to contrast hypercholesterolemia, highlighting its potential as a sustainable multitarget natural extract for the nutraceutical industry that is rapidly gaining acceptance as a source of health-promoting compounds.

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Environmentally‐Friendly Pesticidal Activities ofCallicarpaandKaromiaEssential Oils from Vietnam and Their Microemulsions

Nguyen

Hùng

Quân

et al. 2023

Chemistry & Biodiversity

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There is an ongoing interest to identify alternative pesticidal agents to avoid the chronic problems associated with synthetic pesticides. Essential oils have shown promise as botanical pest control agents. In the present study, the essential oils of four members of the Lamiaceae (Callicarpa candicans, C. erioclona, C. macrophylla, and Karomia fragrans; Vietnamese names: Nàng nàng, Tu châu lông mem, Tu châu lá to and Cà diện, respectively), obtained from wild populations in Vietnam, have been obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry. The essential oils were formulated into microemulsions and the essential oils and their microemulsions were screened for mosquito larvicidal activity against Aedes aegypti, Aedes albopictus, Culex quinquefasciatus, and for molluscicidal activity against Pomacea canaliculata. Atractylone and (E)-caryophyllene dominated the volatiles of C. candicans (CCEO) and C. erioclona (CEEO), while the major component in C. macrophylla (CMEO) and K. fragrans (KFEO) was (E)-caryophyllene. The essential oils and microemulsions of both C. candicans and C. erioclona exhibited excellent larvicidal activity against all three mosquito species (Ae. aegypti, Ae. albopictus, and Cx. quinquefasciatus) with LC 50 values < 10 μg/mL. Additionally, the larvicidal activity of the microemulsions were significantly improved compared with their free essential oils, especially for C. candicans and C. erioclona. All four essential oils and their microemulsions showed excellent molluscicidal activity with LC 50 < 10 μg/mL. In most cases, the essential oils and microemulsions showed greater pesticidal activity against target organisms than the non-target freshwater fish, Oreochromis niloticus. The in silico studies on physicochemical and ADMET properties of the major components in the studied essential oils were also investigated and most of the compounds possessed a favorable ADMET profile. Computational modeling studies of the studied compounds demonstrated a favorable binding interaction with the mosquito odorantbinding protein target and support atractylone, β-selinene, and caryophyllene oxide as potential inhibitors. Based on the observed pesticidal activities of the essential oils and their microemulsions, the Callicarpa species Supporting information for this article is available on the WWW under

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Larvicide Activity on Aedes aegypti of Essential Oil Nanoemulsion from the Protium heptaphyllum Resin

Cited by 18 publications

References 31 publications

Biocidal Activity of a Nanoemulsion Containing Essential Oil from Protium heptaphyllum Resin against Aedes aegypti (Diptera: Culicidae)

Biocidal Activity of a Nanoemulsion Containing Essential Oil from Protium heptaphyllum Resin against Aedes aegypti (Diptera: Culicidae)

Bioactive Triterpenes of Protium heptaphyllum Gum Resin Extract Display Cholesterol-Lowering Potential

Environmentally‐Friendly Pesticidal Activities ofCallicarpaandKaromiaEssential Oils from Vietnam and Their Microemulsions

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