Laryngeal cancer at the Korle Bu Teaching Hospital, Accra, Ghana

Kitcher, ED; Yarney, Joel; Gyasi, RK; Cheyuo, Cletus

doi:10.4314/gmj.v40i2.36016

Cited by 18 publications

(23 citation statements)

References 10 publications

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“…In this study squamous cell carcinoma was identified in 90.3% of all the cases, whereas Kitcher et al (2006) reported of an incidence of 88.7%, Amusa et al (2011) identified 100% in their study and Iseh et al (2011) also identified 66.7%.…”

Section: Discusssionsmentioning

confidence: 46%

“…Adenocarcinoma and adenoid cystic carcinoma were each identified in 2.1% of the cases whereas Kitcher et al (2006) also reported of an incidence of 1.7%. Olofsson andvan Vostrand (1977), Del Negro et al (2007), Zvrko and Golobović (2009) all reported of an incidence rate of less than 1.0% in their respective studies.…”

Section: Discusssionsmentioning

confidence: 96%

“…Even though not much has been reported in Ghana, a similar retrospective study was conducted on 115 patients at the Korle Bu Teaching Hospital (KBTH), Accra, from January, 1998to December, 2003(Kitcher et al 2006. In their study, squamous cell carcinoma was identified in 88.7% of the cases, whereas adenocarcinoma was found in 1.7%, spindle cell carcinoma in 1.7% and 6.1% were defined as unspecified.…”

Section: Opoku Buabeng and Owusu-afriyie 17mentioning

confidence: 99%

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Histological pattern of laryngeal cancers in Komfo Anokye Teaching Hospital

Opoku-Buabeng¹,

Owusu-Afriyie²

2014

Jnl Sci Tech

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Carcinoma of the larynx is one of the commonest malignant tumours of the upper respiratory system.The main objective of this study was to highlight the histological pattern and evaluate the occurrence of the malignant tumours of the larynx. This was a retrospective study involving 146 patients aged between 36 to 77 years with an average age of 59.7 years. Patients with symptoms and signs of laryngeal tumour were studied at the Komfo Anokye Teaching Hospital, Kumasi for a 10 year period from 2003 to 2012. Biopsies of suspected cases were taken and sent to the Histopathology Laboratory for histological analysis. The study revealed that there was a high occurrence of squamous cell carcinoma resulting in 92.0% of the patients. This was followed by verrucous carcinoma in 3.4% of the patients, adenocarcinoma and adenoid cystic carcinoma in 1.7% of the patients. Lastly, there was neuroendocrine carcinoma in only one patient (0.9%). This study confirmed histologically that the squamous cell carcinoma was the most frequently manifested tumour of the larynx.

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Section: Discusssionsmentioning

confidence: 46%

Section: Discusssionsmentioning

confidence: 96%

Section: Opoku Buabeng and Owusu-afriyie 17mentioning

confidence: 99%

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Histological pattern of laryngeal cancers in Komfo Anokye Teaching Hospital

Opoku-Buabeng¹,

Owusu-Afriyie²

2014

Jnl Sci Tech

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“…Clinical manifestations of laryngeal carcinoma in adolescents may include hoarseness or cough, which may be mistaken for common respiratory infections, pre-pubertal voice change, or other benign childhood conditions 24 . Recurrent respiratory tract infection, or asthma, vocal abuse, difficult examination in children makes the case more aggressive and ultimately fatal 16,17 .…”

Section: Discussionmentioning

confidence: 99%

Carcinoma larynx in a 10-year-old girl: a rare clinical entity

Islam

Ahmad

Huda

2012

Bangladesh J of Otorhinolaryngology

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“…It is well known that head and neck cancer is the eighth most common cause of cancer death worldwide [1]. la ryn geal cancer is one of the head and neck malignant tu mors that se riously lead to health damage.…”

mentioning

confidence: 99%

Inhibition of cell proliferation and arrest of cell cycle progression by blocking chloride channels in human laryngeal cancer cell line Hep-2

Zhao²,

Wang³

et al. 2009

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Chloride channel (ClC) is involved in normal physiological processes and pathology of various diseases. Although it is recognized that blockade of ClC inhibits the cell proliferation, it is not well understood the potential function of ClC in laryngeal cancer. In this study, we investigated the effect of the ClC inhibitor on cell proliferation, cell cycle progression in human laryngeal cancer cell line Hep-2, as well as the effect on the phosphorylation levels of ERK1/2 and AKT1. In this study crystal violet method was used to study the effect of the ClC inhibitor, 5-nitro-2-(3-phenylpropylamino) benzoic acid, NPPB, on Hep-2 cell proliferation. The impaction of the inhibitor on the cell cycle distribution was investigated by the flow cytometry (FCM). Western blot was performed to measure the phosphorylation levels of ERK1/2 and AKT1. Our data indicated ClC played an important role in Hep-2 cell proliferation and cell cycle. NPPB inhibited Hep-2 cell proliferation when compared with the controls. Blockade of ClC arrested cell cycle progression and suppressed the phosphorylation of ERK1/2 and AKT1 in Hep-2 cells by inhibition of cell proliferation by CIC inhibitor (NPPB) could be through arresting cell cycle progression, which is probably by suppressing phosphorylation of ERK1/2 and AKT1.

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Laryngeal cancer at the Korle Bu Teaching Hospital, Accra, Ghana

Abstract: We conclude that significant number of patients with laryngeal cancer presented with locally advanced disease and dysphonia was the commonest symptom.

Cited by 18 publications

References 10 publications

Histological pattern of laryngeal cancers in Komfo Anokye Teaching Hospital

Histological pattern of laryngeal cancers in Komfo Anokye Teaching Hospital

Carcinoma larynx in a 10-year-old girl: a rare clinical entity

Inhibition of cell proliferation and arrest of cell cycle progression by blocking chloride channels in human laryngeal cancer cell line Hep-2

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