Laryngeal Helicobacter pylori Infection and Laryngeal Cancer-Case Series and a Systematic Review

Abstract

Helicobacter pylori (H. pylori) infection involves the development of gastric cancer and may be associated with laryngeal cancer. However, laryngeal H. pylori infection in Taiwanese patients with newly diagnosed laryngeal cancer has not been reported. This study was aimed to investigate the possible association between laryngeal H. pylori infection and laryngeal cancer in Taiwan and perform a systematic review of previous reports in other countries. An analysis of 105 patients with laryngeal lesions found the positive rates of H. pylori DNA (determined by polymerase chain reaction) and antigen (determined by immunohistochemistry) of the laryngeal lesions were relatively low (vocal polyps: 3% and 3%; vocal fold leukoplakia: 0% and 0%; laryngeal cancers: 0% and 2%). Furthermore, H. pylori-associated laryngopharyngeal reflux and the expression of E-cadherin and CD1d (determined by immunohistochemistry) were comparable among the three subgroups. Fifteen studies were involved in the systematic review of the digital literature database, distributed to February 2021. The data of patients with laryngeal cancer and controls showed that the laryngeal H. pylori infection rates were 29.4% and 16.7%, respectively. Although current evidence supported that laryngeal H. pylori infection was associated with laryngeal cancer globally, it might not play a role in the development of laryngeal cancer in Taiwan.

Application of an Interpretable Machine Learning Model to Predict Lymph Node Metastasis in Patients with Laryngeal Carcinoma

“…In this study, we found that more than 90% of LC patients were over 50 years old or had squamous cell carcinoma (Table 1), which was consistent with some previous studies [31]. Moreover, LNM was more common among males than females (Table 1), which matches the overall sex-based incidence of LC and may be associated with higher smoking and drinking rates in males [32]. Mutlu et al found that the incidence of cervical metastasis occurring in supraglottic tumours was signifcantly higher than that in transglottic tumours (55.2% and 35.1%, respectively) [33], which was similar to our results that the occurrence proportion of LNM was highest in the supraglottic region (Table 1).…”

A novel pyroptosis-related gene signature to predict outcomes in laryngeal squamous cell carcinoma

“…LSCC is responsible for ~ 98% of all laryngeal cancers [ 1 ]. Etiological factors for LSCC are diverse and include genetic background, environmental factors, alcohol consumption, cigarette smoking, and viral infections [ 2 ]. Approximately 1.8 million new cases and 1 million deaths of LSCC occur worldwide per year [ 3 ].…”