Laryngeal Papillary Squamous Cell Carcinoma

Dutta, Rahul; Husain, Qasim; Kam, David; Dubal, Pariket M.; Baredes, Soly; Eloy, Jean Anderson

doi:10.1177/0194599815581613

Cited by 21 publications

(3 citation statements)

References 22 publications

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“…The survival rate of LC differs in different regions. Survival rate is influenced by many factors such as T stage, N stage, tumor location, and differentiation degree [ 22 – 24 ], while some conclusions were different such as the nutritional status of patients before treatment, smoking and drinking history, and treatment options. Many researchers have indicated that Cox proportional hazards analysis results revealed that T stage, pathological differentiation, and N stage were independent factors that affect the prognosis of LC.…”

Section: Resultsmentioning

confidence: 99%

Clinical Significance of miR-149 in the Survival of Patients with Laryngeal Squamous Cell Carcinoma

Lin

Yang

et al. 2016

BioMed Research International

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MicroRNAs (miRNAs) play critical roles in the progression of laryngeal cancer (LC). In this study, we aimed to investigate whether miR-149 is associated with the prognosis of patients with LC. A total of 97 laryngeal squamous cell carcinoma patients who underwent tumor resection were included in our follow-up study. In vitro studies was performed in cancer cell line Hep-2 to explore the antitumor role of miR-149 in LC. We found that the expression of miR-149 was significantly lower in tumor tissues, compared with vocal cord polyp tissues (P < 0.05). Kaplan-Meier analysis revealed that miR-149 expression status is significantly associated with survival duration (log rank test, P < 0.05), and multivariate Cox regression analysis revealed that patients with low miR-149 expression had shorter survival times compared with patients with high miR-149 expression. In vitro studies revealed that the exogenous expression of miRNA-149 inhibits the proliferation of human Hep-2 cells and induces cell apoptosis. Our study suggests that miR-149 expression in laryngeal squamous cell carcinoma tissues is critically associated with the prognosis of patients, and the ectopic expression of miR-149 in Hep-2 cells inhibits proliferation and cell cycle progression.

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Section: Resultsmentioning

confidence: 99%

Clinical Significance of miR-149 in the Survival of Patients with Laryngeal Squamous Cell Carcinoma

Lin

Yang

et al. 2016

BioMed Research International

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“…In this variant, a 7:1 male predominance was observed, with the majority of cases presenting in white races [ 13 ]. Findings from another study on a rare distinct entity of laryngeal cancer from typical SCC, namely laryngeal papillary SCC over 1973–2011 in the US, demonstrated that this histopathological subtype corresponds to 0.5% of all laryngeal tumors, with a 3:1 male predominance and no racial preference; however, the incidence trends were not investigated [ 12 ]. Reports from another rare variant of laryngeal cancer, laryngeal adenocarcinoma not otherwise specified, which refers to variants of minor salivary gland tumors of the larynx that do not align with other established histological subtypes, demonstrated an overall incidence of 0.008 per 100,000 within 2000–2012, with males (80.2%) and whites (84.7%) constituting the majority of cases [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Laryngeal cancer incidence trends in the United States over 2000–2020: a population-based analysis

Mousavi,

Ilaghi,

Aslani

et al. 2024

Arch Public Health

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Introduction Laryngeal cancers account for one-third of all head and neck cancers. We aimed to report the incidence trends of laryngeal cancer over 2000–2020 in the United States (US), by age, sex, race/ethnicity, and histological subtypes. Methods Data from the Surveillance, Epidemiology, and End Results 22 database were used to identify patients with laryngeal cancer based on the International Classification of Diseases for Oncology, version 3. Age-standardized incidence rates (ASIRs) for laryngeal cancer, adjusted for reporting delays, were calculated. The Joinpoint Regression Program was then utilized to determine annual percent changes (APCs) and average annual percent changes (AAPCs) in the trends. The analysis excluded data from 2020 to prevent potential bias related to the COVID-19 pandemic. Results A total of 104,991 cases of laryngeal cancer were identified in the US from 2000 to 2019. Squamous cell carcinoma was the predominant subtype, accounting for 94.53% of cases. Above 73.20% occurred among non-Hispanic whites, with the highest incidence observed among individuals aged 55–69 years (46.71%). The ASIRs were 5.98 and 1.25 per 100,000 population for men and women, respectively. Over 2000–2019, there was a significant reduction in ASIRs for laryngeal cancer in both sexes. Non-Hispanic black men exhibited the highest ASIR (9.13 per 100,000) and the largest decline in the ASIRs over 2000–2019 (AAPC: -3.26%). Conclusions Laryngeal cancer incidence rates showed a decline from 2000 to 2019, in addition to 2020, during the COVID-19 pandemic. Additional research is required to investigate risk factors and their influence on incidence rates of laryngeal cancer.

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“…Laryngeal squamous cell carcinoma is one of the most common malignant tumors, accounting for 14% of head and neck tumors, while squamous carcinoma is the most common type of laryngeal cancer, accounting for about 93-99% of laryngeal cancer 1,2 . Over the past 40 years, the incidence of laryngeal squamous cell carcinoma has declined steadily, while the 5-year survival rate has not improved signi cantly, especially in the advanced stage, where early symptoms are not signi cant and about 60% of patients are not diagnosed until the advanced stage (stage III or IV) 3,4 . Due to the characteristics of occultation, invasiveness, recurrence and metastasis, it has low sensitivity to chemo/radiotherapy, strong resistance and poor curative effect.…”

Section: Introductionmentioning

confidence: 99%

The Direct Effects of Different Irradiation Methods on The Survival of Laryngeal Squamous Carcinoma Hep2 Cells

Tian¹,

Huang²,

Wang³

2020

Preprint

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Radiotherapy plays an important role in the treatment of laryngeal squamous cell carcinoma. However, radiation resistance is an important cause of radiotherapy failure. To determine the direct effects of different irradiation methods on the survival of Hep2 cells, three different irradiation methods were used in vitro to explore the effects on the colony formation, cycle and apoptosis, showing that different irradiation methods had inhibitory effects on the colony formation of Hep2 cells. Radioactive 125I continuous low dose rate radiation (CLDR) has a stronger inhibitory function, and single dose radiation (SDR) is also superior to fractionated dose radiation (FDR). The G1 phase decreased more significantly, while the G2/M phase ratio also increased significantly in CLDR group. The CLDR group was more significant increase in the early apoptosis and general apoptosis. During these process, the production of higher γ-H2AX, Cyclin D1, Cdc2, NF-κB p21, CyclinB1 and lower p-Cdc25c in CLDR group were observed. Taken together, the continuous low-dose rate irradiation of 125I seeds can significantly increase the apoptosis rate of Hep2 cells, resulting in continuous G2/M phase arrest and significantly inhibiting the proliferation ability of Hep2 cells

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Laryngeal Papillary Squamous Cell Carcinoma

Abstract: This analysis of the largest sample of LPSCC demonstrates a better prognosis for this pathology compared with other laryngeal malignancies.

Cited by 21 publications

References 22 publications

Clinical Significance of miR-149 in the Survival of Patients with Laryngeal Squamous Cell Carcinoma

Clinical Significance of miR-149 in the Survival of Patients with Laryngeal Squamous Cell Carcinoma

Laryngeal cancer incidence trends in the United States over 2000–2020: a population-based analysis

The Direct Effects of Different Irradiation Methods on The Survival of Laryngeal Squamous Carcinoma Hep2 Cells

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