Clinical Significance of miR-149 in the Survival of Patients with Laryngeal Squamous Cell Carcinoma

Xu, Yi; Lin, Yunpeng; Yang, Dong; Zhao, Guanghui; Zhou, Hongyu

doi:10.1155/2016/8561251

Cited by 21 publications

(12 citation statements)

References 23 publications

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“…The gene serves as an anti-oncogene in colorectal cancer [35], HCC [36], laryngeal squamous cell carcinoma [37], and renal cell carcinoma [38]. In contrast, the gene functioned as an oncogene gene in T-cell acute lymphoblastic leukemia [39] and prostate cancer [40].…”

Section: Discussionmentioning

confidence: 99%

Identifying Differentially Expressed MicroRNAs Between Cirrhotic and Non-Cirrhotic Hepatocellular Carcinoma and Exploring Their Functions Using Bioinformatic Analysis

Mei¹,

You²,

Jin³

et al. 2018

Cell Physiol Biochem

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Background/Aims: Few studies have been designed to directly investigate the exact mechanisms underlying the different phenotypes between cirrhotic and non-cirrhotic hepatocellular carcinoma (HCC). This study aimed to illuminate the incidence and developmental mechanisms for both types of HCC through differentially expressed microRNAs (miRNAs) using bioinformatic analysis. Methods: The miRNA-seq data and clinical data of patients (from The Cancer Genome Atlas (TCGA) database) were utilized to determine differentially expressed miRNAs between cirrhotic and non-cirrhotic HCC. Afterwards, the function of the selected miRNAs was predicted with online tools. Furthermore, the miRNA expression and clinical significance were validated by external datasets and our experiment. Results: The present study included 135 non-cirrhotic and 80 cirrhotic patients to find differentially expressed miRNAs. Among them, four miRNAs (mir-1296, mir-23c, mir-149, and mir-95) were finally selected for further validation and analysis. Correlation analysis found that two miRNAs are greatly associated with the non-cirrhotic HCC patients’ clinical traits, such as the T, M, and N tumor stages. However, only mir-23c was associated with the cirrhotic HCC patients’ tumor T and N stages. Furthermore, survival analysis revealed that increased mir-149 in non-cirrhotic HCC, patients’ age and the existence of vessels in the tumor in cirrhotic HCC were independent risk factors for the patients’ postoperative overall survival. Functional and interaction analyses also supported the notion that these miRNAs function through some pathways that influence the behavior of the HCC. These results are strongly supported by analysis of extra datasets and our experiment. Conclusions: The cirrhotic and non-cirrhotic HCC types involve differentially expressed miRNAs, which are correlated with distinctive pathological traits. To some extent, non-cirrhotic HCC seems more dependent on miRNA network regulation, but additional studies are needed to confirm this conclusion.

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Section: Discussionmentioning

confidence: 99%

Identifying Differentially Expressed MicroRNAs Between Cirrhotic and Non-Cirrhotic Hepatocellular Carcinoma and Exploring Their Functions Using Bioinformatic Analysis

Mei¹,

You²,

Jin³

et al. 2018

Cell Physiol Biochem

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“…miRNA149 has been identified as a potent tumor suppressor within a variety of cancer types including breast, laryngeal squamous cell carcinoma, and glioblastoma. [29][30][31] In most of these cancer types the suppressive ability seems to be linked to inhibition of proliferation where reduced levels of miRNA149 leads to unchecked proliferation. Moreover, increasing miRNA149 expression can induce apoptosis in both neuroblastoma and HeLa cells by inhibiting RAC-alpha serine/threonine-protein kinase 1 (Akt1) and Transcription factor E2F1 expression.…”

Section: Discussionmentioning

confidence: 99%

Micro-RNA149 confers taxane resistance to malignant mesothelioma cells via regulation of P-glycoprotein expression

Kenworthy

Bosco

DeLigio

et al. 2018

Cancer Biology & Therapy

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Multidrug resistance (MDR) represents a major hindrance to the efficacy of cancer chemotherapeutics. While surgical resection, radiation, and chemotherapy can be used to reduce tumor size, the subsequent appearance of drug resistant cells is a frequent problem. One of the main contributors to the development of MDR is increased expression of multi-drug resistant protein 1 (MDR1), also known as P-glycoprotein (P-gp). P-gp is a membrane-associated efflux pump that can efficiently remove internalized taxane-base chemotherapeutics thus preventing drug accumulation and maintaining cellular viability. Consequently, investigation into the molecular mechanisms responsible for regulation of P-gp expression is necessary to facilitate treatment of MDR tumors. Using molecular and biochemical approaches, we identified that the micro-RNA, miRNA149, contributes to the development of MDR within malignant mesothelioma cells by regulating the expression of MDR1.

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“…Quantitative polymerase chain reaction was selected for further analysis of some of these miRNAs, but researchers did not find a connection between miRNA‐149 and KD . In searching the literature, we found that miRNA‐149 has a definite association with some cancers, such as lung cancer, colorectal cancer, laryngeal squamous cell carcinoma, hepatocellular carcinoma, and neuroblastoma . To a certain extent, the alteration of rs2292832 T>C in miRNA ‐149 may cause alterations in expression and susceptibility to diseases.…”

Section: Introductionmentioning

confidence: 99%

Association between the miRNA‐149 rs2292832 T>C polymorphism and Kawasaki disease susceptibility in a southern Chinese population

Jiang

et al. 2019

Clinical Laboratory Analysis

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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. AbstractBackground: Kawasaki disease (KD), which is characterized by vasculitis, is prone to occur in patients under 5 years of age, has an ambiguous etiology, and displays coronary artery lesions as the chief complication. Previous studies have linked miRNA-149 to cancers, and rs2292832 T>C is related to allergic diseases and inflammatory bowel disease, which both show immune system disorders and coronary artery disease. Therefore, we performed a study concentrating on the association between the miRNA-149 rs2292832 T>C polymorphism and KD susceptibility. Methods:The subjects enrolled were 532 children with KD and 623 controls. We used TaqMan real-time PCR to obtain the genotypes of the rs2292832 T>C polymorphism. Results:Ultimately, no significant association was found between the miRNA-149 rs2292832 T>C polymorphism and KD susceptibility, even in stratification analysis. Conclusion:Our results indicated that in southern Chinese patients, the miRNA-149 rs2292832 T>C polymorphism did not affect KD susceptibility, which needs to be further confirmed. K E Y W O R D S Kawasaki disease, miRNA-149, polymorphism S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section. How to cite this article: Li J, Wang J, Su X, et al. Association between the miRNA-149 rs2292832 T>C polymorphism and Kawasaki disease susceptibility in a southern Chinese population. J Clin Lab Anal. 2020;34:e23125. https ://doi.

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Clinical Significance of miR-149 in the Survival of Patients with Laryngeal Squamous Cell Carcinoma

Cited by 21 publications

References 23 publications

Identifying Differentially Expressed MicroRNAs Between Cirrhotic and Non-Cirrhotic Hepatocellular Carcinoma and Exploring Their Functions Using Bioinformatic Analysis

Identifying Differentially Expressed MicroRNAs Between Cirrhotic and Non-Cirrhotic Hepatocellular Carcinoma and Exploring Their Functions Using Bioinformatic Analysis

Micro-RNA149 confers taxane resistance to malignant mesothelioma cells via regulation of P-glycoprotein expression

Association between the miRNA‐149 rs2292832 T>C polymorphism and Kawasaki disease susceptibility in a southern Chinese population

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