Laryngeal solitary multiple mucosal neuromas without multiple endocrine neoplasia (MEN) type 2B

Shimazaki, Takatsugu; Yoshida, Yoshikazu; Izumaru, Shinsuke; Nakashima, Tadashi

doi:10.1016/s0385-8146(02)00115-3

Cited by 12 publications

(11 citation statements)

References 10 publications

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“…Twelve articles with MN cases without MEN 2B were reviewed [5][6][7][8][9][10][12][13][14][15][16][17]; all articles were published before December 2019. The epidemiology, clinical presentation, surgical treatment, and outcome of this sample population are described in Table 1.…”

Section: Literature Reviewmentioning

confidence: 99%

“…MN of MEN 2B is always observed on the mucosal surfaces of the lips, tongue, eyelids, and intestines of patients [4], but rarely occur without the other abnormality about MEN 2B. MN without MEN 2B have been reported in the rectosigmoid colon [5], bronchi [6,7], conjunctiva [8], laryngeal [9,10,15], tongue [12][13][14][15], lip [13]and hard palate [16], but there has been no reported case in the gingiva to our knowledge.…”

Section: Introductionmentioning

confidence: 99%

“…Clinically, MN usually presents as a rm, slowly enlarging, small, circumscribed mass, which is painless in most cases [3,7,13,16], although it can frequently cause symptoms such as pain and paresthesia [5,6,9,10,15]. In the vast majority of cases, complete surgical excision is curative; however, recurrences have been reported in some cases [14,17].…”

Section: Introductionmentioning

confidence: 99%

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Solitary mucosal neuroma in the maxillary incisor gingival papilla without multiple endocrine neoplasia type 2B (MEN 2B): a case report and literature review

Qiu

Wang

Chen

et al. 2020

Preprint

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Background Mucosal neuroma (MN) is a benign neural tumor of peripheral nerves histologically characterized by irregular tortuous bundles of nerve cells with prominent perineurium that lie scattered throughout the submucosa. The tumor is usually associated with the multiple endocrine neoplasia type 2B (MEN 2B) but rarely occurs without the other components of MEN 2B. We present a case of solitary MN without MEN 2B that occurs in the maxillary incisor gingival papilla that has not been reported yet and review the literature. Case presentation: A 29-year-old woman presented to our outpatient department with an upper anterior teeth gingiva painless mass for 2-year. Intraoral examination revealed a small, tough, basal wide, well-defined mass in the labial gingival papilla between maxillary central incisor. Excisional biopsy showed that it was characterized by nerve bundles in various sizes surrounded by normal connective tissue in the submucosa under HE staining; Immunohistochemically, the mass showed strongly positive staining of S-100 protein, NSE,NF and weakly positive of EMA. The Laboratory examination and ultrasonography showed no signs of MEN 2B. In the first 6 months of follow-up, there was no evidence of recurrence and other components of MEN 2B. The patient was asymptomatic and she is still being followed up every 6 months. Based on these features, the lesion was finally diagnosed as a solitary gingival MN. Conclusions This study showed a rare solitary MN in the gingiva papilla without MEN 2B that has not been reported yet. The histopathological evaluation can be helpful in the differential diagnosis of MN. It is hoped that a greater understanding of solitary MN without MEN 2B in the oral cavity will avoid potential misdiagnosis, and contribute to determining the correct management, which appears to be complete surgical excision with close follow-up for recurrence and other components of MEN 2B surveillance.

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Section: Literature Reviewmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Solitary mucosal neuroma in the maxillary incisor gingival papilla without multiple endocrine neoplasia type 2B (MEN 2B): a case report and literature review

Qiu

Wang

Chen

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…Multiple mucosal neuromas represent a cardinal feature *Multiple laryngeal neuromas have also been described in a 73-year-old man with a persistent cough due to chronic bronchitis and with no evidence of MEN2B. 83 †Age at diagnosis (rather than onset) of neuromas. ‡Diagnosis of neuroma was not confirmed histopathologically.…”

Section: 21034mentioning

confidence: 99%

“…50,69,[74][75][76][77][78][79][80][81][82][83] At least 6 patients had cutaneous and mucosal lesions, 50,74,76,77,81,82 and 11 patients were noted to have prominent corneal nerves. 50,74,[77][78][79][80]82 In 4 affected families, genetic analysis confirmed the absence of mutations in the RET protooncogene.…”

Section: 21034mentioning

confidence: 99%