Laryngotracheitis herpesvirus infection in the chicken. II. The adoptive transfer of resistance with immune spleen cells

Fahey, K. J.; York, Jennifer J.; Bagust, T. J.

doi:10.1080/03079458408418530

Cited by 37 publications

(15 citation statements)

References 24 publications

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“…This finding contrasted with previous studies which showed that bursectomized chickens, which were unable to synthesize specific antibodies, could be protected against clinical disease by vaccination (Robertson, 1977;Fahey et al, 1983). Although cellular immunity may prevent clinical ILT and mortalities in vaccinated chickens (Fahey et al, 1984) the question of whether mucosal antibody assists in the clearance of a primary infection from the trachea, or plays a role in preventing the establishment of a secondary infection remains unanswered.…”

Section: Introductioncontrasting

confidence: 55%

The role of mucosal antibody in immunity to infectious laryngotracheitis virus in chickens

Fahey

York

1990

Journal of General Virology

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The role of mucosal antibody in recovery from a primary infection and resistance to reinfection with infectious laryngotracheitis (ILT) herpesvirus was studied in bursectomized chickens, which were unable to synthesize specific antibodies. Viral antigen in the infected trachea was assessed by indirect immunofluorescence on tissue sections and by ELISA. The ability of bursectomized chickens to resolve primary infections as effectively as intact chickens and of vaccinated-bursectomized chickens to prevent the replication of challenge virus without the participation of mucosal antibody, is evidence for the importance of local cell-mediated rather than humoral immune mechanisms in the outcome of infection with ILT virus.

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Section: Introductioncontrasting

confidence: 55%

The role of mucosal antibody in immunity to infectious laryngotracheitis virus in chickens

Fahey

York

1990

Journal of General Virology

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“…Naive chickens can be protected against challenge infection by the transfer of immune lyphoid cells [7], while bursectomised chickens that are unable to synthesise specific antibodies are protected against a challenge infection by vaccination [6,15].…”

Section: Infectious Laryngotracheitis (Ilt) Is An Acute Upper Respiramentioning

confidence: 99%

Humoral and cell-mediated immune responses to the glycoproteins of infectious laryngotracheitis herpesvirus

York

Fahey

1990

Archives of Virology

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The viral glycoproteins of infectious laryngotracheitis virus, an alphaherpesvirus, were the dominant antigens recognised by immune chickens. Glycoproteins with molecular weights of 205, 160, 115, 90, 67, 60, and 52k reacted strongly in Western blotting studies with a majority of chicken antisera. Viral glycoproteins immunoprecipitated using monoclonal antibodies were also able to elicit a delayed-type hypersensitivity reaction in chickens previously vaccinated with a live vaccine. The 60 k glycoprotein alone and the antigenically related family of higher molecular weight glycoproteins (205, 160, 115, 90, and 85 k) both elicited significant increased in the thickness of the wattles of immune cockerels. Because the glycoproteins induce both antibody and cell-mediated immune responses they may prove to be important protective immunogens in a subunit vaccine.

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“…The virulent CSW-1 strain of ILTV (Fahey et al, 1984), and the SA-2 commercial vaccine strain of ILTV (Arthur Webster Pty Ltd, Sydney, Australia) were used in this study.…”

Section: Virusesmentioning

confidence: 99%

“…In a previous study various inbred lines of White Leghorn chickens were found to differ in their susceptibility to infectious laryngotracheitis after intratracheal challenge (Fahey et al, 1984;Loudovaris et al, 1991). This paper describes an in vitro investigation of the comparative susceptibility of macrophages from three of these inbred lines of chicken to infection by ILTV.…”

Section: Introductionmentioning

confidence: 99%

Genetic susceptibility of chicken macrophages toin vitroinfection with infectious laryngotracheitis virus

et al. 1991

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SUMMARYChicken macrophages are susceptible to infection with infectious laryngotracheitis virus (ILTV), the level of infection being dependent, in part, on the genotype of the host cell. Following infection in vitro a greater proportion of macrophages from the ILTV-resistant J 1 (B 113/113 ) and N 1 (B 114/114 ) inbred lines of chickens were found to be positive for ILTV antigens, than macrophages from the ILTV-susceptible M 1 (B 15/15 ) chickens. The proportion of ILTVpositive macrophages was found to be genetically regulated, in part by the chicken major histocompatibility complex (MHC), although alloantisera to class I and class II MHC antigens did not reduce the number of macrophages infected. Similarly, the phagocytic activity of the cultured macrophages from chickens of different MHC genotype did not correlate with their susceptibility to infection with ILTV.

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Laryngotracheitis herpesvirus infection in the chicken. II. The adoptive transfer of resistance with immune spleen cells

Cited by 37 publications

References 24 publications

The role of mucosal antibody in immunity to infectious laryngotracheitis virus in chickens

The role of mucosal antibody in immunity to infectious laryngotracheitis virus in chickens

Humoral and cell-mediated immune responses to the glycoproteins of infectious laryngotracheitis herpesvirus

Genetic susceptibility of chicken macrophages toin vitroinfection with infectious laryngotracheitis virus

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