Laser-ablation sampling for inductively coupled plasma distance-of-flight mass spectrometry

Gundlach‐Graham, Alexander; Dennis, Elise A.; Ray, Steven J.; Enke, Christie G.; Barinaga, Charles J.; Koppenaal, David W.; Hieftje, Gary M.

doi:10.1039/c4ja00231h

Cited by 13 publications

(19 citation statements)

References 53 publications

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“…The concept of space-focusing in CEA-TOFMS is well established as is the use of a reflectron to mirror the space focus and to partially compensate for ionenergy disparities [23]. The concept of energy-focused CMA was introduced in 2007 [24] and has been applied to both distance-of-flight MS (DOFMS) [25][26][27][28][29][30][31] and TOFMS [22,32,33].…”

Section: Introductionmentioning

confidence: 99%

“…The 40.68 MHz ICP ionization source (crystal-controlled, model HF 2000F; PlasmaTherm Inc., Kresson, NJ, USA) used in this study has been previously described in detail [29,30]. Commercially available analytical reagent grade 1000 ppm stock solutions or analytical reagent grade nitrate salts (from several different manufacturers) were used to prepare all sample and standard solutions.…”

Section: Sample Preparation Introduction and Ionizationmentioning

confidence: 99%

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Inductively Coupled Plasma Zoom–Time-of-Flight Mass Spectrometry

Dennis

Ray

Enke³

et al. 2015

J. Am. Soc. Mass Spectrom.

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Abstract. A zoom-time-of-flight mass spectrometer has been coupled to an inductively coupled plasma (ICP) ionization source. Zoom-time-of-flight mass spectrometry (zoom-TOFMS) combines two complementary types of velocity-based mass separation. Specifically, zoom-TOFMS alternates between conventional, constantenergy acceleration (CEA) TOFMS and energy-focused, constant-momentum acceleration (CMA) (zoom) TOFMS. The CMA mode provides a mass-resolution enhancement of 1.5-1.7× over CEA-TOFMS in the current, 35-cm ICP-zoom-TOFMS instrument geometry. The maximum resolving power (full-width at half-maximum) for the ICP-zoom-TOFMS instrument is 1200 for CEA-TOFMS and 1900 for CMA-TOFMS. The CMA mode yields detection limits of between 0.02 and 0.8 ppt, depending upon the repetition rate and integration time-compared with single ppt detection limits for CEA-TOFMS. Isotope-ratio precision is shot-noise limited at approximately 0.2% relative-standard deviation (RSD) for both CEA-and CMA-TOFMS at a 10 kHz repetition rate and an integration time of 3-5 min. When the repetition rate is increased to 43.5 kHz for CMA, the shot-noise limited, zoom-mode isotope-ratio precision is improved to 0.09% RSD for the same integration time.

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Section: Introductionmentioning

confidence: 99%

Section: Sample Preparation Introduction and Ionizationmentioning

confidence: 99%

Inductively Coupled Plasma Zoom–Time-of-Flight Mass Spectrometry

Dennis

Ray

Enke³

et al. 2015

J. Am. Soc. Mass Spectrom.

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“…ince the development of distance-of-flight mass spectrometry (DOFMS) theory by Enke and Dobson [1], several papers have shown its experimental viability [2][3][4][5][6][7][8][9]. Conceptually, mass-to-charge (m/z) separation in DOFMS is similar to that in time-of-flight mass spectrometry (TOFMS), while the ion detection process resembles that of spatially dispersive, sectorfield mass spectrometry (SFMS).…”

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confidence: 99%

“…The MCP/phosphor assembly has a 4.0-cm active length [2] and, in combination with a CCD camera, provides a linear dynamic range (LDR) of five orders of magnitude [5] and a full-width at half-maximum mass resolving power (RP FWHM ) of approximately 500 [6]. However, the MCP/phosphor screen detector must be coupled to a scientific camera for massspectral acquisition [2], suffers an inherent mass bias due to the MCPs, and does not detect the true mass-spectral peak width because of secondary electron amplification and resulting Coulombic repulsion [5].…”

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confidence: 99%

“…Earlier work on DOFMS was conducted with two alternative ion detectors employed in the same instrument [9]: a microchannel plate-phosphor screen (MCP/phosphor) combination [2,[5][6][7] and a multichannel focal plane camera (FPC) [3,4]. The MCP/phosphor assembly has a 4.0-cm active length [2] and, in combination with a CCD camera, provides a linear dynamic range (LDR) of five orders of magnitude [5] and a full-width at half-maximum mass resolving power (RP FWHM ) of approximately 500 [6].…”

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confidence: 99%

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Distance-of-Flight Mass Spectrometry with IonCCD Detection and an Inductively Coupled Plasma Source

Dennis

Ray

Enke³

et al. 2015

J. Am. Soc. Mass Spectrom.

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Abstract. Distance-of-flight mass spectrometry (DOFMS) is demonstrated for the first time with a commercially available ion detector-the IonCCD camera. Because DOFMS is a velocity-based MS technique that provides spatially dispersive, simultaneous mass spectrometry, a position-sensitive ion detector is needed for massspectral collection. The IonCCD camera is a 5.1-cm long, 1-D array that is capable of simultaneous, multichannel ion detection along a focal plane, which makes it an attractive option for DOFMS. In the current study, the IonCCD camera is evaluated for DOFMS with an inductively coupled plasma (ICP) ionization source over a relatively short field-free mass-separation distance of 25.3-30.4 cm. The combination of ICP-DOFMS and the IonCCD detector results in a mass-spectral resolving power (FWHM) of approximately 900 and isotope-ratio precision equivalent to or slightly better than current ICP-TOFMS systems. The measured isotope-ratio precision in % relative standard deviation (%RSD) was ≥0.008%RSD for nonconsecutive isotopes at 10-ppm concentration (near the ion-signal saturation point) and ≥0.02%RSD for all isotopes at 1-ppm. Results of DOFMS with the IonCCD camera are also compared with those of two previously characterized detection setups.

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Recent Advances in Instrumental Approaches to Time‐of‐flight Mass Spectrometry

Brais

Orejas

Schwartz

et al. 2020

Mass Spectrometry Reviews

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Time-of-flight mass spectrometry (TOFMS) is one of the simplest and most powerful approaches for mass spectrometry. Realization of the advantages inherent in TOFMS requires innovation in the theory and practice of the technique. Instrumental developments, in turn, create new capabilities that enable applications in chemical measurement. This review focuses on the recent advances in TOFMS instrumentation. New strategies for ion acceleration, multiplexed detection, miniaturized TOFMS instruments, approaches to extend the length of ion flight, and novel ion detection technologies are reviewed. Techniques that change the basic paradigm of TOFMS by measuring m/z based on ion flight distance are considered, as are applications at the frontiers of instrumental performance.

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Laser-ablation sampling for inductively coupled plasma distance-of-flight mass spectrometry

Abstract: Laser-ablation (LA) sample introduction is combined with a new simultaneous multi-element determining, velocity-based ICPMS approach called distance-of-flight mass spectrometry (DOFMS).

Cited by 13 publications

References 53 publications

Inductively Coupled Plasma Zoom–Time-of-Flight Mass Spectrometry

Inductively Coupled Plasma Zoom–Time-of-Flight Mass Spectrometry

Distance-of-Flight Mass Spectrometry with IonCCD Detection and an Inductively Coupled Plasma Source

Recent Advances in Instrumental Approaches to Time‐of‐flight Mass Spectrometry

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