Laser and antimicrobial photodynamic therapy for the management of delayed healing following multiple dental extractions in a post-radiotherapy patient

Tateno, Ricardo Yudi; Palma, Luiz Felipe; Sendyk, Wilson Roberto; Campos, Luana

doi:10.1016/j.pdpdt.2020.101764

Cited by 10 publications

(3 citation statements)

References 8 publications

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“…Applied, noninvasive laser therapy was well tolerated by the patient. It does not cause adverse effects and promotes induction of tissue repair, pain control and modulation of the inflammatory process [6] , in this case, aPDT combined with surgical therapy, promotes microbial reduction that seems to have contributed greatly to clinical success and is revealed as a promising adjuvant therapy.…”

Section: Discussionmentioning

confidence: 98%

“…It appears that the therapy conducted in the association of the surgical maneuver with aPDT was successful. aPDT consists of the interaction of light with the photosensitizer and oxygen, generating free radicals that induce severe damage to microbial cells, leading to their death [6] . This therapy is associated with surgical maneuvers effectively eradicating stage 2 osteonecrosis in the mandibular region.…”

Section: Discussionmentioning

confidence: 99%

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aPDT associated with sequestrectomy in the treatment of osteonecrosis in cancer patients with metastasis: Case report

Pacheco

Tholt

Veiga

et al. 2022

International Journal of Surgery Case Reports

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

aPDT associated with sequestrectomy in the treatment of osteonecrosis in cancer patients with metastasis: Case report

Pacheco

Tholt

Veiga

et al. 2022

International Journal of Surgery Case Reports

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“…Since ORN is challenging to treat, prevention has great importance. 13 The required sample size was calculated based on a previous study on the mandibular ORN model following RT to ensure accurate results. 14 Using a one-way analysis of variance test, a minimum of 24 animals were needed to detect an effect size of 1 with a 95% power.…”

Section: Introductionmentioning

confidence: 99%

Effects of systemic Anatolian propolis administration on a rat-irradiated osteoradionecrosis model

ÇOLAK,

ERDIL,

GEVREK

2023

J. Appl. Oral Sci.

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Effects of systemic Anatolian propolis administration on a rat-irradiated osteoradionecrosis modelObjective: Radiotherapy after head and neck cancer is associated with the risk of osteonecrosis development. This study aims to investigate the effectiveness of systemic propolis application to prevent the disease as it has no definite treatment protocol despite the proposed treatment methods and significantly decreases individuals' quality of life. Methodology: In total, 29 male Wistar-Albino rats were divided into control, 35 Gy irradiation (Group 1), 35 Gy irradiation+100 mg/kg/ml propolis administration (Group 2), and 35 Gy irradiation+200 mg/kg/ml propolis administration groups (Group 3). Propolis was first applied on the day after radiotherapy, except for the control group. Right first and second molars were extracted from all rats three weeks following radiotherapy. Samples were collected seven weeks after radiotherapy. Osteoblast and osteoclast counts were calculated by histomorphometric analysis. Immunohistochemical analysis determined bone morphogenic protein-2 (BMP-2) and transforming growth factor beta-3 (TGFβ-3). Results: Group comparison found non-significant differences regarding osteoblast (p=0.130) and osteoclast (p=0.063) counts. However, Group 1 showed the lowest mean osteoblast (OBL: 82.63 [±13.10]) and highest mean osteoclast counts (OCL: 12.63 [±5.55]). OBL/OCL ratio showed significant differences between groups (p=0.011). Despite the significant difference between the Control and Groups 1 (p=0.006) and 2 (p=0.029), Group 3 showed a non-significant difference (p=0.091). For BMP-2 and TGFB3, the control group showed significant differences with the other two groups (p<0.001), except for Group 3. Conclusion: Anatolian propolis showed beneficial effects in a radiotherapy-mediated osteonecrosis model, highlighting its potential as a promising intervention.

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Role of Photodynamic Therapy in Osteonecrosis and Osteoradionecrosis of the Jaws: A Systematic Review

Poorna,

Joshna,

Alagarsamy

et al. 2024

J. Maxillofac. Oral Surg.

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Laser and antimicrobial photodynamic therapy for the management of delayed healing following multiple dental extractions in a post-radiotherapy patient

Cited by 10 publications

References 8 publications

aPDT associated with sequestrectomy in the treatment of osteonecrosis in cancer patients with metastasis: Case report

aPDT associated with sequestrectomy in the treatment of osteonecrosis in cancer patients with metastasis: Case report

Effects of systemic Anatolian propolis administration on a rat-irradiated osteoradionecrosis model

Role of Photodynamic Therapy in Osteonecrosis and Osteoradionecrosis of the Jaws: A Systematic Review

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