Laser and cisplatinum for treatment of human squamous cell carcinoma

Paiva, Marcos B.; Graeber, Ines P.; Castro, Dan J.; Suh, Michael; Paek, Woo H.; Eshraghi, Adrien A.; Saxton, Romaine E.

doi:10.1097/00005537-199809000-00002

Cited by 12 publications

(13 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further studies on the impact of quality of life after therapy will be crucial to better access the potential of LITT‐UTZ for malignant cervical adenopathy. A promising development of image‐guided treatments of tumors in the neck would be to combine local injections of thermally enhanced cytotoxic drugs such as cisplatin with LITT through fiberoptics under MRI guidance 8,13,14 . MRI‐guided procedures will improve the precision of drug and laser delivery and is the quintessential goal of treatment for recurrent head and neck cancer developed by the investigators at UCLA 8,14 …”

Section: Discussionmentioning

confidence: 99%

Ultrasound‐Guided Laser‐Induced Thermal Therapy of Malignant Cervical Adenopathy

Bublik¹,

Sercarz²,

Lufkin³

et al. 2006

The Laryngoscope

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Ultrasound‐Guided Laser‐Induced Thermal Therapy of Malignant Cervical Adenopathy

Bublik¹,

Sercarz²,

Lufkin³

et al. 2006

The Laryngoscope

Self Cite

View full text Add to dashboard Cite

show abstract

“…Because lymph node metastasis is an important prognostic factor, especially in patients with squamous cell carcinoma (5) (for whom the recurrence rate 5 years after surgery and chemoradiation is 50%–60% (6–9)), it is imperative to detect early metastasis of retropharyngeal lymph node with an imaging modality. While computed tomography (CT) is the imaging modality of choice for staging cervical metastasis (13–15), MRI is superior to CT in differentiating retropharyngeal node immediately adjacent to great vessels and other vital structures to direct tumor extension.…”

Section: Discussionmentioning

confidence: 99%

MRI‐guided access to the retropharynx

Lai

Maghami

Borges

et al. 2003

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Purpose To describe MR‐guided access to the retropharynx for precise fine‐needle aspiration cytology (FNAC), and other indications for needle placement. Materials and Methods A retrospective review was made of 15 procedures that had been performed on 14 patients. These patients had a retropharyngeal mass on MRI and had undergone MR‐guided minimally invasive access to the retropharynx for either diagnostic or therapeutic intervention in the period of October 1989 to January 2000. Results All 14 patients underwent MR‐guided access to the retropharynx for FNAC without immediate or delayed complications. MRI confirmed that the biopsy needle was within the retropharyngeal mass in all patients. MR‐guided FNAC revealed five true‐positive, five true‐negative, four indeterminate, and no false‐positive cases. Ten of the 14 patients (71%) had diagnostic aspirations. In one patient with retropharyngeal extension of carcinoma, an MR‐guided approach was used for the experimental interstitial laser therapy (ILT). Conclusion The results suggest that an MR‐guided retromandibular approach to biopsy of retropharyngeal mass is minimally invasive and safe. J. Magn. Reson. Imaging 2003;17:317–322. © 2003 Wiley‐Liss, Inc.

show abstract

“…The CDDP drug implant also may provide an alternative combined technique with LITT for more effective therapy without systemic drug toxicity. Combining CDDP/ gel with LITT in a human squamous cell carcinoma tumor transplant model resulted in significant therapeutic improvement compared to systemic or intratumor injection of cisplatin in several recent pre-clinical studies [5,25,26]. Currently, patients with advanced head and neck cancer are palliated at UCLA either by laser ablation in a phase II study or by intralesional cisplatin injection (CDDP/ epi-gel, phase III study) with clear evidence of tumor regression in a number of patients, but with eventual recurrence in the majority of cases [15,24].…”

Section: Discussionmentioning

confidence: 99%

“…An obvious next step is to combine intratumor cisplatin injections with interstitial Nd: YAG laser therapy for cancer treatment [5,26].…”

Section: Discussionmentioning

confidence: 99%

Combined Cisplatinum and Laser Thermal Therapy for Palliation of Recurrent Head and Neck Tumors

Paiva

Saxton

Blackwell

et al. 1999

Diagnostic and Therapeutic Endoscopy

Self Cite

View full text Add to dashboard Cite

In recent years endoscopically controlled laser-induced thermal therapy (LITT) has been increasingly accepted as a minimally invasive method for palliation of advanced or recurrent head and neck or gastrointestinal cancer. Previous studies have shown that adjuvant chemotherapy can potentiate endoscopic laser thermal ablation of obstructing tumors leading to improved palliation in advanced cancer patients. Eight patients with recurrent head and neck tumors volunteered to enroll as part of an ongoing phase II LITT clinical trial, and also elected to be treated with systemic chemotherapy (cisplatin, 80 mg/m2) followed 24 h later by palliative laser thermal ablation. Laser treatments were repeated in patients with residual disease or recurrence for a total of 27 LITT sessions. Four of the 8 patients treated with laser thermal chemotherapy remained alive after a median follow-up of 12 months. Of the 12 tumor sites treated, complete responses were located in the oral cavity (3), oropharynx (1), hypopharynx (1), maxillary sinus (1), and median survival for these patients was 9.5 months. This initial experience with cisplatinum-based laser chemotherapy indicates both safety and therapeutic potential for palliation of advanced head and neck cancer but this must be confirmed by longer follow-up in a larger cohort of patients.

show abstract

Laser and cisplatinum for treatment of human squamous cell carcinoma

Abstract: These initial results suggest that laser chemotherapy may become an effective treatment for advanced head and neck cancer.

Cited by 12 publications

References 39 publications

Ultrasound‐Guided Laser‐Induced Thermal Therapy of Malignant Cervical Adenopathy

Ultrasound‐Guided Laser‐Induced Thermal Therapy of Malignant Cervical Adenopathy

MRI‐guided access to the retropharynx

Combined Cisplatinum and Laser Thermal Therapy for Palliation of Recurrent Head and Neck Tumors

Contact Info

Product

Resources

About