Laser-assisted triggered-drug release from silver nanoparticles-grafted dual-responsive polymer

Abstract

Laser assisted drug release from a synthesized plain polymer composed of poly (butyl methacrylate-co-acrylamide-co-methacrylic acid) [P(BMA-co-AAm-co-MAA)] and a metallo-polymer composed of silver nanoparticles (Ag NPs) grafted plain polymer (the nanocomposite) were studied to investigate their capability to serve as drug carriers. Positive temperature dependent swelling changes were observed for both carriers and their thermal sensitivity and thermal and optical switching properties were investigated in two buffered solutions. An acidic solution with pH=1.2 to simulate stomach body condition and a neutral solution with pH=7.4 to simulate intestine condition. Reversible phase transition (collapsing/swelling) with fast response time in the order of few seconds were observed by applying heat or by applying light radiation at the surface plasmon resonance wavelength of the attached NPs. Finally, cumulative release (%) of ofloxacin antibiotic as a model drug was investigated for both thermal and optical switching conditions. Based on these results, pulsatile release was observed which have the "on" and "off" states at higher and lower temperatures with respect to their volume-phase transition temperatures respectively.

Iron oxide nanoparticles decorated oleic acid for high colloidal stability

“…From Table 1, the zeta potential for undecorated MNPs sample was about −29.8 mV. [9] Meanwhile, the zeta potential was further decreased up to −58.1 mV after incorporating 1.5 wt.% of OA into the same pH medium. [9] Meanwhile, the zeta potential was further decreased up to −58.1 mV after incorporating 1.5 wt.% of OA into the same pH medium.…”

“…This negative value from the zeta potential was attributed to the OH − ions associated with the surface of MNPs sample at a pH 10 medium. [9] Meanwhile, the zeta potential was further decreased up to −58.1 mV after incorporating 1.5 wt.% of OA into the same pH medium. This observed condition was attributed to the carboxylate ions which were surrounded by the nanoparticle's outer layer, which might be promoted by the high stability strength for MNPs colloidal.…”

Recent Developments in Antibacterial Therapy: Focus on Stimuli-Responsive Drug-Delivery Systems and Therapeutic Nanoparticles

“…Photothermal heating can either be used to deliver thermal energy to a localised area as reported by Khan and colleagues in their research work [16], or, alternatively, throughout the drug carrier, thereby causing the destruction of the encapsulating material and triggering the release of the loaded therapeutics. Some early demonstrations of the use of photothermal effects to release antibacterial agents from drug carriers have been reported in a number of research studies [17,18,19,20].…”

“…The release of lysozymes from photothermally degraded capsules led to rapid bacterial digestion being observed. In the work by Amoli-Diva and co-workers [18], Ag NPs were embedded within a poly(butyl methacrylate-co-acrylamide-co-methacrylic acid) hydrogel to provide the controlled release of the model antibiotic ofloxacin following irradiation with a 405 nm laser for 15 s at the 10, 30 and 50 min after the start of the experiment. After 70 min, a significantly higher amount of ofloxacin (>80% of total mass) was released from these samples than from the non-irradiated samples.…”

Stimuli‐Responsive Release of Antimicrobials Using Hybrid Inorganic Nanoparticle‐Associated Drug‐Delivery Systems

“…In contrast, no changes in the extinction spectra were observed for the non‐irradiated mixture of intact capsules. In another approach, Ag NPs were embedded within a poly(butyl methacrylate‐ co ‐acrylamide‐ co ‐methacrylic acid) hydrogel to provide controlled release of the model antibiotic ofloxacin following irradiation with a 405 nm laser for 15 s at the 10, 30, and 50 min mark after the start of the experiment . After 70 min, a significantly higher amount of ofloxacin (>80% of total mass) was found to be released at both pH 7.4 and 1.2 when compared to the non‐irradiated samples.…”