Laser biospectroscopy and 5-ALA fluorescence navigation as a helpful tool in the meningioma resection

Abstract

5-aminolevulinic acid (5-ALA) is a natural precursor of protoporphyrin IX (PP IX), which possesses fluorescent properties and is more intensively accumulated in tumor cells than in normal tissue. Therefore, the use of 5-ALA in the surgical treatment of intracranial tumors, particularly gliomas, has gained popularity in the last years, whereas its use in other intracranial pathological entities including meningiomas has been reported occasionally. This study describes a series of 28 patients with intracranial meningiomas, who were administered 5-ALA for a better visualization of tumor boundaries. Twelve patients underwent also laser spectroscopic analysis in order to confirm the visual impression of tumor tissue visualization. Bone infiltration was readily demonstrated. In one case, the tumor recurrence could have been prevented by removal of a tumor remnant, which would possibly have been better recognized if spectroscopic analysis had been used. Fluorescent navigation (FN) is a useful method for maximizing the radicality of meningioma surgery, particularly if the tumor infiltrates the bone, the skull base, and/or the surrounding structures

Tissue Optics and Photonics: Light-Tissue Interaction II

“…The S 1 →S 0 transition with fluorescence emission (hν F ) is the basis of PDD [130,152]. The higher quantum efficiency of singlet oxygen ( 1 O 2 ) generation, the lower is the fluorescence quantum yield.…”

Intraoperative fluorescence diagnostics in surgery of intracranial meningiomas: analysis of 101 cases

“…[20][21][22]. Однако чувствительность и специфичность флуоресценции, а также показания к ее применению в хирургии интракраниальных менингиом, остаются предметом исследований [23][24][25][26][27][28].…”

Nanoparticle-enabled experimentally trained wavelet-domain denoising method for optical coherence tomography

“…14,23,64,65 Recently, numerous modern techniques of tissue imaging are considered to solve this problem: intraoperative magnetic resonance imaging, 66,67 terahertz reflectometry, [68][69][70] Raman spectroscopy, [71][72][73] and fluorescence imaging. 74,75 Among them, OCT remains one of the most promising instrument, which yields noninvasive, fast, and label-free 2-D and 3-D visualisation of tissues, providing both lateral and depth information about its structure and scattering properties. Many biomedical applications of OCT imaging deal with objects featuring finally structured heterogeneous semi-infinite scattering medium with local inclusions possessing high (or low) scattering.…”