Laser coagulation zones induced with the Nd-YAG laser in the liver

Orth, Klaus; Russ, Detlef; Duerr, Jochen; Hibst, Raimund; Mattfeldt, Torsten; Steiner, Rudolf; Beger, Hans G.

doi:10.1007/bf02763983

Cited by 9 publications

(5 citation statements)

References 26 publications

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“…The sequence could discern the boundaries of irreversible damage in normal liver tissue in vivo. In recent years, there has been increased interest in LI'IT via developments in efficacy, monitoring, and delivery techniques (5,7,8,14,(16)(17)(18)(19)(20)(21)(22)(23)(24). This is particularly true as it has been found that MRI can noninvasively monitor the laser-tissue interaction on a time frame commensurate with the effects: complete monitoring of the thermal distribution has always been problematic in LI'IT.…”

Section: Discussionmentioning

confidence: 99%

Invited. MRI of laser‐induced interstitial thermal injury in an in vivo animal liver model with histologic correlation

Morrison

Jólesz

Charous

et al. 1998

Magnetic Resonance Imaging

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Laser-induced interstitial thermal therapy (LITT) is a preferred method of minimally invasive therapy. MRI is a noninvasive method by which to monitor the thermal effects of LITT. To properly control such effects, changes in MRI parameters during and after LITT should be correlated with changes in the tissue. T1-weighted fast spin echo (FSE) MRI (1 image/10 seconds) at 1.5 T monitored LITT in vivo in rabbit liver (n = 6) using an interstitial bare delivery fiber (600-microm diameter; 3.0 W; 1,064 nm; 150 seconds). During laser irradiation, MRI signal intensity decreased around the fiber tip; after irradiation, this hypointensity proved reversible and permanent lesions were evident. The lesions had hyperintense margins that were brighter than surrounding normal tissue (P < .001); the tissue in these bright regions was mapped to tissue necrosis characterized by the presence of thermally damaged ghost red blood cells amid generally normal hepatocytes. T1-FSE identified the spatial extent of the LITT lesions.

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Section: Discussionmentioning

confidence: 99%

Invited. MRI of laser‐induced interstitial thermal injury in an in vivo animal liver model with histologic correlation

Morrison

Jólesz

Charous

et al. 1998

Magnetic Resonance Imaging

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“…The suitability of the selected treatment parameters must, therefore, be demonstrated experimentally in tissue phantoms or in animal models. In situ interstitial temperatures generated during clinical or experimental laser irradiation are generally measured with thermocouple probes [15,16], infrared optical fibers [17,18], optical temperature sensors such as temperaturesensitive fluorescent probes [19,20], and MRI monitoring [21].…”

Section: Introductionmentioning

confidence: 99%

In Situ temperature measurements with thermocouple probes during laser interstitial thermotherapy (LITT): Quantification and correction of a measurement artifact

Manns¹,

Milne²,

González-Cirre³

et al. 1998

Lasers Surg. Med.

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“…Measurement of axial (depth) and radial damages of coagulated and carbonized tissue were performed by direct observation under a light microscope (Eclipse 80i, Nikon Co, Tokyo, Japan). Volumes of coagulated and carbonized tissue were estimated using the 3D ellipsoidal tissue volume formula [8].…”

Section: Measuring and Evaluation Proceduresmentioning

confidence: 99%

“…Thermal damage (lesion formation) to tissue depends on the thermal and optical properties of tissues as well as laser irradiation parameters. In this modality, hyperthermia is observed over 43 °C, coagulation is believed to start around 60 °C, evaporation and/or ablation occurs above 100 °C, and carbonization over 300 °C [7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

An experimental study on photothermal damage to tissue: the role of irradiance and wavelength

2016

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Laser exposure time and irradiance are crucial parameters governing the process of thermal damage. The goal of our in vitro study was to study and determine optimal parameters for the onset of coagulation and carbonization at three different wavelengths (980, 1070 and 1940 nm). We also compared photothermal effects at these three wavelengths by varying laser exposure time and irradiance. Fresh bovine liver specimens were used for experimentation. The onset of thermal damage at different irradiances and for different exposure time was studied macroscopically and histologically. Photothermal damage or lesion volume generally decreased with irradiance and increasing exposure time. We observed an exponential and linear relationship between irradiance and exposure time for specific thermal endpoints. These specific endpoints were the onset of (i) coagulation, and (ii) carbonization. The time interval or difference between these specific endpoints termed as Δt (t carbonization − t coagulation ) (s) was also determined. This relation between irradiance and exposure time will make possible the pre-estimation of thermal tissue lesion volume before operation, and photothermal therapy may thus be performed with minimum side effects on liver tissue.

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Laser coagulation zones induced with the Nd-YAG laser in the liver

Cited by 9 publications

References 26 publications

Invited. MRI of laser‐induced interstitial thermal injury in an in vivo animal liver model with histologic correlation

Invited. MRI of laser‐induced interstitial thermal injury in an in vivo animal liver model with histologic correlation

In Situ temperature measurements with thermocouple probes during laser interstitial thermotherapy (LITT): Quantification and correction of a measurement artifact

An experimental study on photothermal damage to tissue: the role of irradiance and wavelength

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