Laser cutting: influence on morphological and physicochemical properties of polyhydroxybutyrate

Lootz, D.; Behrend, D.; Kramer, Sven; Freier, Thomas; Haubold, Axel D.; Benkiesser, G; Schmitz, Klaus‐Peter; Becher, Bärbel

doi:10.1016/s0142-9612(00)00245-3

Cited by 36 publications

(24 citation statements)

References 8 publications

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“…In a study by Lootz et al [34], P(3HB) films were treated employing a coherent CO 2 laser providing 150 W of power. Polariscopic analysis of thin sections of the laser-treated films showed structural dissimilarities, which were manifested as different brightness and color of the laser-treated regions.…”

Section: Discussionmentioning

confidence: 99%

Laser processing of polymer constructs from poly(3-hydroxybutyrate)

Volova

Tarasevich

Golubev

et al. 2015

Journal of Biomaterials Science, Polymer Edition

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CO2 laser radiation was used to process poly(3-hydroxybutyrate) constructs - films and 3D pressed plates. Laser processing increased the biocompatibility of unperforated films treated with moderate uniform radiation, as estimated by the number and degree of adhesion of NIH 3T3 mouse fibroblast cells. The biocompatibility of perforated films modified in the pulsed mode did not change significantly. At the same time, pulsed laser processing of the 3D plates produced perforated scaffolds with improved mechanical properties and high biocompatibility with bone marrow-derived multipotent, mesenchymal stem cells, which show great promise for bone regeneration.

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Section: Discussionmentioning

confidence: 99%

Laser processing of polymer constructs from poly(3-hydroxybutyrate)

Volova

Tarasevich

Golubev

et al. 2015

Journal of Biomaterials Science, Polymer Edition

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“…Grabow et al reported on cutting of poly(l-lactide) (PLLA) stent using CO 2 laser, 23 whereas Lootz et al investigated the effect of CO 2 laser cutting on polyhydroxybutyrate. 24 In a recent study, Kancharla and Chen micropatterned poly-d-lactic acid and polyvinyl alcohol directly using UV lasers. 25 These long-pulse laser systems generate laser pulses that have a time period longer than the thermal wave propagation in the material.…”

Section: Introductionmentioning

confidence: 99%

Multiscale Topological Guidance for Cell Alignment via Direct Laser Writing on Biodegradable Polymer

Yeong

Lim

et al. 2010

Tissue Engineering Part C: Methods

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Direct laser writing on biodegradable polymer to create microchannels for aligning cells is presented here. This technique offers the advantages of ease-of-manufacturing, ease-of-design, high-speed single-step fabrication, and noncontacting to the material. In this work, microchannels of 100 microm width, 100 microm depth, and 50 microm intervals were created on a biodegradable polymer film directly using a Ti-sapphire femtosecond pulsed laser. Multiscale topological features were achieved as a result of the laser beam-material interaction. These topological features were used to guide cell alignment in the microchannels. We present results on the morphology of poly(L-lactide-co-epsilon-caprolactone) copolymer micromachined by femtosecond laser and demonstrate the attachment and alignment of C2C12 myoblast cells in the microchannels. C2C12 cells exhibited favorable attachment in the channels after 1 day of seeding. High degree of alignment was observed after 4 days as cells proliferated into a confluent patch inside the channels. This work demonstrated the potential of wavy surface features combined with appropriate channel size for high-density cell alignment using direct laser writing. This method also offers the opportunity to incorporate multiscale topological guidance on other biodegradable polymer implants, such as vascular scaffolds and stents, which require directed cell organization.

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“…For example, Lootz et al considered machining of polyhydroxybutyrate stents with a carbon dioxide laser [79]. In particular, they examined embrittlement of these stents after carbon dioxide laser machining.…”

Section: Laser Fabrication Of Cardiovascular Devicesmentioning

confidence: 99%

Laser Engineering of Surface Structures

Narayan

Goering

Balani³

et al. 2014

Biosurfaces

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Over the past half century, rapid progress has been made in laser-based medical diagnosis and treatment, as well as in laser-based medical device fabrication. Lasers have unique capabilities for coating, machining, melting, polymerizing, sintering, and welding materials that are used in implantable and transdermal medical devices. In this review, academic and industrial developments involving laser processing of materials for dental, orthopedic, neural, ophthalmic, cardiovascular and transdermal applications are described. In addition, laser processing of nanoscale materials for medical applications is discussed. Finally, the challenges associated with commercialization of laser biomaterials are considered. Due to the unique capabilities provided by laser-based processes, it is anticipated that the use of laser biomaterials in implantable and transdermal medical devices will markedly increase over the coming years.

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Laser cutting: influence on morphological and physicochemical properties of polyhydroxybutyrate

Cited by 36 publications

References 8 publications

Laser processing of polymer constructs from poly(3-hydroxybutyrate)

Laser processing of polymer constructs from poly(3-hydroxybutyrate)

Multiscale Topological Guidance for Cell Alignment via Direct Laser Writing on Biodegradable Polymer

Laser Engineering of Surface Structures

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