Laser-Doppler measurement of skin blood flow: comparison with plethysmography

Johnson, John M.; Taylor, W. F.; Shepherd, A. P.; Park, Myung K.

doi:10.1152/jappl.1984.56.3.798

Cited by 213 publications

(137 citation statements)

References 26 publications

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“…Laser Doppler blood flow was recorded in millivolts, which are directly related to blood flow in the microcirculation of the surface tissue (17). Absolute blood flow, in ml/minute/100 gm of tissue, can be approximated by multiplying the laser Doppler signal, in millivolts, by 4.…”

Section: Methodsmentioning

confidence: 99%

The post‐occlusive hyperemic response in patients with systemic sclerosis

Wigley

Wise

Mikdashi

et al. 1990

Arthritis & Rheumatism

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We investigated post‐ischemic hyperreactive cutaneous blood flow in patients with primary Raynaud's phenomenon and Raynaud's phenomenon secondary to systemic sclerosis (SSc). Reactive hyperemia was measured over a locally warmed area of skin, using a laser Doppler flowmeter, following 5 minutes of suprasystolic occlusion of blood flow. We found that patients with primary Raynaud's phenomenon had normal post‐ischemic blood flow compared with normal controls. In contrast, patients with SSc had reduced levels of baseline and peak blood flow compared with either the primary Raynaud's phenomenon patients or the normal subjects. Infusion of carbaprostacyclin, a potent prostacyclin analog vasodilator, did not increase blood flow in the SSc patients, nor did it restore the reactive hyperemic response. These findings are consistent with the hypothesis that patients with the nonvasoconstricted condition of SSc have fixed structural defects that limit cutaneous microvascular blood flow.

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Section: Methodsmentioning

confidence: 99%

The post‐occlusive hyperemic response in patients with systemic sclerosis

Wigley

Wise

Mikdashi

et al. 1990

Arthritis & Rheumatism

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“…Thus, the purpose of this study was to determine if there are gender differences in local or central control of cutaneous blood flow that could account for the increased incidence of Raynaud's disease in women. 4 To measure hand blood flow, a water-filled plethysmograph was used. The water temperature of the plethysmograph was thermostatically controlled and continuously monitored and could be adjusted to warm or cool the hand.…”

mentioning

confidence: 99%

Sex differences in control of cutaneous blood flow.

et al. 1990

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Women are far more likely than men to suffer from Raynaud's disease. The purpose of this study was to determine whether there are gender differences in local or central control of cutaneous blood flow that could account for the increased incidence of Raynaud's disease in women. To assess cutaneous blood flow, hand blood flow (HBF), finger blood flow (FBF), or skin perfusion (SP) was measured by fluid plethysmography, mercury strain-gauge plethysmography, or laser Doppler spectroscopy, respectively, in 47 volunteers. Basal HBF in men exceeded that of women (12.1±2.0 versus 6.2±1.5 mlU100 ml/min). Likewise, FBF in men surpassed that of women (19.5±4.1 versus 7.7±1.8 ml/100 mlVmin). Similarly, SP in men was greater than that of women (270±42 versus 81±16 perfusion units). However, after total body warming (to induce a thermal sympatholysis), HBF in women exceeded that of men, suggesting that the lower basal HBF in women was due to increased sympathetic outflow to the extremities. Mental stress and deep inspiration reduced HBF and SP in men. Paradoxically, both of these maneuvers increased HBF and SP in women. To determine whether these paradoxical responses in women were due to the women's elevated basal sympathetic tone, these experiments were repeated after total body cooling in men to increase sympathetic tone and after total body warming in women to reduce sympathetic tone. Total body cooling reduced HBF and SP in men. Under these conditions, mental stress and deep inspiration induced vasodilation. In women, total body warming for 10 minutes increased HBF. Under these conditions, mental stress and deep inspiration induced vasoconstriction. In conclusion, basal cutaneous blood flow is reduced in women. This appears to be due to a basal increase in sympathetic tone rather than to a local structural or functional difference in the cutaneous circulation. In addition, a paradoxical vasodilation in response to mental arithmetic and deep inspiration is unmasked at high levels of sympathetic tone. The gender differences in cutaneous blood flow may account for the increased incidence of Raynaud's disease in young women. (Circulation 1990;82:1607-1615

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“…Cold induces vasoconstriction in cutaneous tissue and this has been confirmed by laser Doppler flowmetry, 6 strain gauge plethysmography 7 and finger skin temperature. 8,9 Adrenergic function is thought to be involved in this coldinduced vasoconstriction, because inhibition of sympathetic adrenergic function significantly reduces the cutaneous vasoconstrictor response to direct local cooling.…”

Section: Vascular Response To Cold Exposure (Vasoconstriction and Vasmentioning

confidence: 78%

Sex Difference in Peripheral Arterial Response to Cold Exposure

Shimizu

Matsushita

Hyodo

et al. 2008

Circ J

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Objective: Hypersensitive aesthesia for coldness is known to occur more frequent in women. We hypothesized that it is derived from sex difference of vascular response to coldness. In order to confirm this hypothesis, we examined the arterial response to cold exposure in rat hindlimbs. Methods: Male (M), female (F) and ovariectomized (OVX) Wistar rats were used. Cold exposure was induced by cooling spray on the hindlimb. Tissue temperature was recorded using digital thermometer after cold exposure. Synchrotron radiation microangiography (SRA) with a resolution of 26 um was employed for the measurement of arterial diameter. Timing of imaging was pre and one minute after cold exposure. Results: The reduction in temperature was significant in F and OVX compared with M (p<0.01). SRA showed that arteries of hindlimbs are dilated by cold exposure in all groups. Percentage of arterial dilatation in response to cold exposure was statistically small in F compared with M and OVX (69+/−40% (F), 118+/−73% (M), 99+/−42% (OVX), p < 0.05 vs F, respectively). Conclusion: Although it has been recognized that cutaneous vessels are constricted by cold exposure, the reaction of deep vessels of lower limbs were not investigated in association with gender difference. From this experiment, it is clarified that female arteries are less expansive, and existence of ovarian hormones disturbed the dilation of arteries against cold exposure.

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Laser-Doppler measurement of skin blood flow: comparison with plethysmography

Cited by 213 publications

References 26 publications

The post‐occlusive hyperemic response in patients with systemic sclerosis

The post‐occlusive hyperemic response in patients with systemic sclerosis

Sex differences in control of cutaneous blood flow.

Sex Difference in Peripheral Arterial Response to Cold Exposure

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