Sex Difference in Peripheral Arterial Response to Cold Exposure

Shimizu, Fujio; Matsushita, Shonosuke; Hyodo, Kazuyuki; Akishima, Shinji; Imazuru, Tomohiro; Tokunaga, Chiho; Enomoto, Yoshiharu; Kanemoto, Shinya; Hiramatsu, Yuji; Sakakibara, Yuzuru

doi:10.1253/circj.72.1367

Cited by 23 publications

(17 citation statements)

References 29 publications

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“…Vascular constriction due to cold exposure is greater in women than in men in both superficial and deep arteries. 25 – 28 This augmented cold-induced vasoconstriction in women may be due to increased activity of adrenergic alpha2C-receptor, the expression of which is enhanced by estrogen. 26 It is possible that greater vascular sensitivity to outdoor temperature among women is responsible for the larger impact of temperature on stroke.…”

Section: Discussionmentioning

confidence: 99%

Cumulative Effects of Weather on Stroke Incidence: A Multi-Community Cohort Study in Japan

Matsumoto

Ishikawa

Kajii

2010

Journal of Epidemiology

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BackgroundAlthough seasonal variation in stroke incidence has been reported, it is not known whether year-long exposure to particular meteorological conditions affects the risk of stroke independently of conventional cardiovascular risk factors.MethodsWe conducted a cohort study involving 4849 men and 7529 women residing in 12 communities dispersed throughout Japan. Baseline data were obtained from April 1992 through July 1995. Follow-up was conducted annually to capture first-ever-in-life stroke events. Weather information during the period was also obtained for each community. Multilevel logistic regression analysis was conducted to evaluate the association between stroke incidence and each meteorological parameter adjusted for age, obesity, smoking status, total cholesterol, systolic blood pressure, diabetes, and other meteorological parameters.ResultsOver an average of 10.7 years of follow-up, 229 men and 221 women had stroke events. Among women, high annual rainfall (OR per 1000 mm, 1.46; 95% confidence interval, 1.05–2.03), low average ambient temperature (OR per 1 °C, 0.79; 0.66–0.94), and number of cold days per year (OR per 10 days, 3.37; 1.43–7.97) were associated with increased risk of stroke incidence, independent of conventional risk factors. Among men, number of cold days (OR per 10 days, 1.07; 1.02–1.12) was associated with an increased risk of stroke incidence, but the association became nonsignificant after adjustment for other risk factors. Similar results were obtained for cerebral infarction and cerebral hemorrhage.ConclusionsLong-term exposure to some meteorological conditions may affect the risk of stroke, particularly in women, independent of conventional risk factors.

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Section: Discussionmentioning

confidence: 99%

Cumulative Effects of Weather on Stroke Incidence: A Multi-Community Cohort Study in Japan

Matsumoto

Ishikawa

Kajii

2010

Journal of Epidemiology

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“…[21] In contrast, deep arteries in the rat hind limb were dilated upon exposure to cold. [22] Expansion of deep arteries delivers warm blood to cooled extremities. Less expansion leads to slower recovery to cold temperature.…”

Section: Discussionmentioning

confidence: 99%

Effects of L-citrulline diet on stress-induced cold hypersensitivity in mice

Kobayashi¹,

Narita²,

Chiba³

et al. 2014

Phcog Res

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Background:L-citrulline is an amino acid discovered in watermelon (Citrullus lanatus, Cucurbitaceae) and is a known component of the nitric oxide (NO) cycle that plays an important role in adjusting blood circulation and supplying NO and a key component of the endothelium-derived relaxing factor.Objective:The objective of this study is to evaluate the effect of L-citrulline on a newly established stress-induced cold hypersensitivity mouse model.Materials and Methods:When normal mice were forced to swim in water at 25°C for 15 min, their core body temperature dropped to 28.9°C, and then quickly recovered to normal temperature after the mice were transferred to a dry cage at room temperature (25°C). A 1-h immobilization before swimming caused the core body temperature to drop to ca. 24.1°C (4.8°C lower than normal mice), and the speed of core body temperature recovery dropped to 57% of the normal control. We considered this delay in recovery from hypothermia to be a sign of stress-induced cold hypersensitivity. Similar cold hypersensitivity was induced by administration of 50 mM L-NG-nitroarginine methyl ester, a NO synthesis inhibitor.Results:In this study, we showed that recovery speed from the stress-induced hypothermia remarkably improved in mice fed a 1% L-citrulline-containing diet for 20 days. Furthermore, the nonfasting blood level of L-arginine and L-citrulline increased significantly in the L-citrulline diet group, and higher serum nitrogen oxide levels were observed during recovery from the cold.Conclusions:These results suggested that oral L-citrulline supplementation strengthens vascular endothelium function and attenuates stress-induced cold hypersensitivity by improving blood circulation.

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“…Although microvasculature in rat hind limb has been evaluated by microangiography, the vessel images described in the literature were obtained from the previous version of synchrotron radiation facility [8][9][10][11]. Newly developed angiographic techniques, particularly those using the third-generation SR source, are allowing us to obtain high-resolution images of the microcirculation in small animals [13].…”

Section: Discussionmentioning

confidence: 99%

“…Although microvasculature in rat hind limb has been evaluated by microangiography in vivo [8][9][10][11], the smallest vascular structures (capillaries), which have an inner diameter of less than 10 mm [12], cannot be detected by this technique. Therefore, advanced high-resolution imaging modalities are required for proper visualization.…”

Section: Introductionmentioning

confidence: 99%