Laser Doppler-recorded venoarteriolar reflex in Raynaud's phenomenon

Stoyneva, Zlatka

doi:10.1016/j.autneu.2004.08.012

Cited by 21 publications

(15 citation statements)

References 36 publications

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“…The insufficient VAR may induce increased capillary and subsequently filtration pressure with edema formation and thickening of capillary membranes, as described in secondary Raynaud phenomenon. 26 Our small series confirms the need for smoking cessation and suggests the effectiveness of treatment with IVI. Furthermore, this pilot study underlines the validity of transcutaneous noninvasive monitoring in order to assess lower limbs cutaneous microcirculation and objectively indicate the timing of further pharmacological and nonpharmacological treatments.…”

Section: Discussionsupporting

confidence: 75%

“…Presence of basal low-perfusion LDF values is probably associated with the known increased vasomotor tone of conduit arteries in TAO. 26 The LDF values, recorded at the hallux and forefoot, remained substantially unchanged at follow-up. In contrast, increased vasomotor tone has not prevented a modest increase in flow obtained by posthyperemic maximal test, with the probe from 36 C to 44 C, both at the hallux and ipsilateral forefoot.…”

Section: Noninvasive Transcutaneous Monitoringmentioning

confidence: 85%

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Noninvasive Transcutaneous Monitoring in Long-Term Follow-Up of Patients With Thromboangiitis Obliterans Treated With Intravenous Iloprost

et al. 2014

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We evaluated the effectiveness of intravenous iloprost (IVI) in outpatients with thromboangiitis obliterans (TAO) and lower limb noninvasive transcutaneous monitoring (TCM) at follow-up (FU). Ten consecutive patients with TAO underwent IVI therapy. Transcutaneous oxygen (TcPO 2 ) and carbon dioxide (TcPCO 2 ) determination and laser Doppler flowmetry (LDF) were performed before and after IVI at 3, 6, and 12 months of FU. Clinical response was positive in 7 patients, whereas 3 nonresponders underwent a second IVI cycle with 1 showing a late positive clinical response. After 12 months of FU, all patients were alive without amputations. Supine and dependent TcP 2 levels significantly improved (P < .005). Hallux LDF values showed significant change with the maximal hyperemic test at 44 C (P < .005). Forefoot maximal hyperemic test at 44 C LDF (P < .005) and improved venous arterial reflex (P < .05) showed statistically significant time evolution. We demonstrated some degree of IVI effectiveness and evaluated TCM in patients with TAO.

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Section: Discussionsupporting

confidence: 75%

Section: Noninvasive Transcutaneous Monitoringmentioning

confidence: 85%

Noninvasive Transcutaneous Monitoring in Long-Term Follow-Up of Patients With Thromboangiitis Obliterans Treated With Intravenous Iloprost

et al. 2014

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“…We would like to continue research in this area, using ideas and methods that can be found in other studies. [15][16][17][18][19][20][21][22][23][24][25][26]…”

Section: Discussionmentioning

confidence: 99%

Contribution of laser Doppler flowmetry with venoarteriolar reflex, cold, and rewarming testing, and intravital capillaroscopy to diagnose Raynaud's phenomenon

Zeman¹,

Turyanytsya²,

Kapsa³

et al. 2014

JVD

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Journal of Vascular Diagnostics Dovepresssubmit your manuscript | www.dovepress.com Dovepress 47 M e t h o D o l o g y open access to scientific and medical research open Access Full text Article Background: The early differential diagnosis of Raynaud's phenomenon (RP) is crucial for the prognosis and therapy of these patients. In our microcirculatory laboratory, we use intravital capillaroscopy (IC), plethysmography (P), and laser Doppler flowmetry (LDF) for examining acrosyndromes. We combine LDF with venoarteriolar reflex test, cold test, and rewarming test to achieve more reliable diagnoses of acrosyndromes. Patients and methods: We examined LDF and IC according to a strict protocol using a battery of tests (venoarteriolar reflex test, cold test, rewarming test) applied to five different groups of people and compared their results: healthy controls, primary Raynaud's phenomenon (PRP), systemic scleroderma, vibration white finger, and peripheral artery occlusive disease. Our tests included 340 individuals (72 patients plus 268 controls). Results: Although all tests provided some differences between controls and patients, only the rewarming test offered significant results for differential diagnoses. Conclusion: IC and LDF combined with the battery of tests (venoarteriolar reflex test, cold test, rewarming test) under standard conditions can be used as reliable tools to distinguish between PRP and some types of secondary RP (especially in the case of systemic scleroderma, vibration white fingers, or peripheral artery occlusive disease; RPs with organic occlusions of the small arteries causing the diseases). Our methodology can help to distinguish between other types of RP, as well.

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“…Laser Doppler flowmetry, which is based on recording the Doppler shifts that photons undergo when scattered in moving blood cells, allows continuous and noninvasive recording of cutaneous tissue blood perfusion 7,8) . The method has already contributed to the investigation of the digital vascular abnormalities in HAVS and to an understanding of their pathogenesis 9,10) . However, with an increasing number of applications, a low spatial resolution (less than 1 mm) was revealed to be one of the most severe limitations of the technique because cutaneous circulation is known to be heterogeneous, resulting in significant differences in the perfusion values, even at adjacent sites 18,19) .…”

Section: Discussionmentioning

confidence: 99%

“…Laser Doppler velocimetry is one of the noninvasive methods for the measurement of finger blood flow to surface tissue 7,8) . The technique can be used to investigate the response to a vasoconstrictive stimulus, such as cold water immersion, and has been used with some workers who use hand-held vibrating tools 9,10) . Laser Doppler perfusion imaging (LDPI) is a new technique employing a two-dimensional horizontal scanning of the blood flow in a specific tissue without the necessity for surface contact 11,12) .…”

Section: Introductionmentioning

confidence: 99%

Laser Doppler Imaging of Skin Blood Flow for Assessing Peripheral Vascular Impairment in Hand-Arm Vibration Syndrome

et al. 2007

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The objective of this study was to evaluate the usefulness of laser Doppler imaging (LDPI) of the skin blood flow for assessing peripheral vascular impairment in the hand-arm vibration syndrome (HAVS). The subjects were 46 male patients with HAVS, aged 50 to 69 yr, and 31 healthy male volunteers of similar age as controls. A cold provocation test was carried out by immersing a subject's hand on his more severely affected side into cold water at a temperature of 10°C for 10 min. Repeated image scanning of skin blood flow of the index, middle, and ring fingers was performed every 2 min before, during, and after the cold water immersion using a PMI-II laser Doppler perfusion imager. The mean blood perfusion values in the distal phalanx area of the fingers were calculated on each image. The patients suffering from vibration-induced white finger (VWF, n=20) demonstrated significantly lower skin blood perfusion at each interval of the test as compared with those without VWF (n=26) and the controls (p<0.01, ANOVA). The blood perfusions in the HAVS patients were associated with the severity of the symptoms as classified by the Stockholm Workshop scale for vascular staging. When a subject was considered to be positive if any of the tested fingers showing a decreased blood perfusion and/or a delayed recovery pattern, the sensitivity was 80.0%, and the specificity was 84.6% and 93.5% for patients without VWF and the controls, respectively. These results suggest that the LDPI technique could provide detailed and accurate information that may help detect the existence of impaired vascular regulation to cold exposure in the fingers of workers exposed to hand-transmitted vibration.

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Laser Doppler-recorded venoarteriolar reflex in Raynaud's phenomenon

Cited by 21 publications

References 36 publications

Noninvasive Transcutaneous Monitoring in Long-Term Follow-Up of Patients With Thromboangiitis Obliterans Treated With Intravenous Iloprost

Noninvasive Transcutaneous Monitoring in Long-Term Follow-Up of Patients With Thromboangiitis Obliterans Treated With Intravenous Iloprost

Contribution of laser Doppler flowmetry with venoarteriolar reflex, cold, and rewarming testing, and intravital capillaroscopy to diagnose Raynaud's phenomenon

Laser Doppler Imaging of Skin Blood Flow for Assessing Peripheral Vascular Impairment in Hand-Arm Vibration Syndrome

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Laser Doppler-recorded venoarteriolar reflex in Raynaud's phenomenon

Cited by 21 publications

References 36 publications

Noninvasive Transcutaneous Monitoring in Long-Term Follow-Up of Patients With Thromboangiitis Obliterans Treated With Intravenous Iloprost

Noninvasive Transcutaneous Monitoring in Long-Term Follow-Up of Patients With Thromboangiitis Obliterans Treated With Intravenous Iloprost

Contribution of laser Doppler flowmetry with venoarteriolar reflex, cold, and rewarming testing, and intravital capillaroscopy to diagnose Raynaud&#39;s phenomenon

Laser Doppler Imaging of Skin Blood Flow for Assessing Peripheral Vascular Impairment in Hand-Arm Vibration Syndrome

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Contribution of laser Doppler flowmetry with venoarteriolar reflex, cold, and rewarming testing, and intravital capillaroscopy to diagnose Raynaud's phenomenon