Laser-Driven Radiation Therapy

Habs, D.; Tajima, T.; Köster, U.

doi:10.5772/24190

Cited by 4 publications

(5 citation statements)

References 44 publications

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“…Using this type of acceleration target changes the way the laser is used to manipulate the radiation properties and should also be explored in the future. 26 The laser polarization is another factor affecting the acceleration. 26 The choice between linear and circular polarization affects the shape of the radiated region as well as the electron's final energy.…”

Section: Discussionmentioning

confidence: 99%

“…26 The laser polarization is another factor affecting the acceleration. 26 The choice between linear and circular polarization affects the shape of the radiated region as well as the electron's final energy. Ideally, the polarization could also be controlled in order to better design the patient-specific radiation profile.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that lasers can be used to produce radiation sources in specific wavelengths which are optimized for absorption in nuclear structures dominant in malignant cells. 26 For example, a similar efficient source was produced in the past and required electrons with similar energy levels and a 2-mm target for the γ-ray creation. 27 As in the proposed method, this source allows for shorter treatment ranges and, therefore, reduces possible side effects.…”

Section: Discussionmentioning

confidence: 99%

“…However, it adds complexity to the system and the treatment ranges are shorter. 26 A possible solution could be to use this source together with the electron source, thus increasing treatment effectiveness.…”

Section: Discussionmentioning

confidence: 99%

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Proposed method for internal electron therapy based on high-intensity laser acceleration

Tepper

Barkai²,

Gannot

2015

J. Biomed. Opt

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Radiotherapy is one of the main methods to treat cancer. However, due to the propagation pattern of high-energy photons in tissue and their inability to discriminate between healthy and malignant tissues, healthy tissues may also be damaged, causing undesired side effects. A possible method for internal electron therapy, based on laser acceleration of electrons inside the patient’s body, is suggested. In this method, an optical waveguide, optimized for high intensities, is used to transmit the laser radiation and accelerate electrons toward the tumor. The radiation profile can be manipulated in order to create a patient-specific radiation treatment profile by changing the laser characteristics. The propagation pattern of electrons in tissues minimizes the side effects caused to healthy tissues. A simulation was developed to demonstrate the use of this method, calculating the trajectories of the accelerated electron as a function of laser properties. The simulation was validated by comparison to theory, showing a good fit for laser intensities of up to 2 × 10(20) (W/cm2), and was then used to calculate suggested treatment profiles for two tumor test cases (with and without penetration to the tumor). The results show that treatment profiles can be designed to cover tumor area with minimal damage to adjacent tissues.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Proposed method for internal electron therapy based on high-intensity laser acceleration

Tepper

Barkai²,

Gannot

2015

J. Biomed. Opt

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“…The laser-driven ion acceleration via the interaction of short, intense laser pulses with matter, known as laser-plasma acceleration, is featured by its high accelerating electric fields and short pulse length compared to conventional rf-accelerators. It has been one of the most active areas of research during the last several years (Borghesi et al, 2006;Fuchs et al, 2006;Robson et al, 2007), because the laser-driven ion beams can be employed in a broad range of applications in cancer therapy (Bulanov et al, 2002;Habs et al, 2011), isotope preparation for medical applications (Spencer et al, 2001), proton radiography (Borghesi et al, 2002), and controlled thermonuclear fusion (Roth et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Identification of high energy ions using backscattered particles in laser-driven ion acceleration with cluster-gas targets

Fukuda¹,

Sakaki²,

Kanasaki³

et al. 2013

Radiation Measurements

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A new diagnosis method for high energy ions utilizing a single CR-39 detector mounted on plastic plates is demonstrated to identify the presence of the high energy component beyond the CR-39's detection threshold limit. On irradiation of the CR-39 detector unit with a 25 MeV per nucleon He ion beam from conventional rf-accelerators, a large number of etch pits having elliptical opening shapes are observed on the rear surface of the CR-39. Detailed investigations reveal that these etch pits are created by heavy ions inelastically backscattered from the plastic plates. This ion detection method is applied to laser-driven ion acceleration experiments using cluster-gas targets, and ion signals with energies up to 50 MeV per nucleon are identified.

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Lasers Offer New Tools to Radiobiology and Radiotherapy

Giulietti

Tajima

2016

Biological and Medical Physics, Biomedical Engineering

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Laser-Driven Radiation Therapy

Cited by 4 publications

References 44 publications

Proposed method for internal electron therapy based on high-intensity laser acceleration

Proposed method for internal electron therapy based on high-intensity laser acceleration

Identification of high energy ions using backscattered particles in laser-driven ion acceleration with cluster-gas targets

Lasers Offer New Tools to Radiobiology and Radiotherapy

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