2012
DOI: 10.1016/b978-0-12-391857-4.00001-x
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Laser-Induced Radiation Microbeam Technology and Simultaneous Real-Time Fluorescence Imaging in Live Cells

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Cited by 26 publications
(21 citation statements)
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“…In the current models only a single category of complex DSB has been considered. We expect that the localization of DSB in either euchromatin or heterochromatin may also play role in the biphasic profile, as proposed in [22], [57], and the slower repair of complex DSB may allow alternate pathways to compete for repair [3] especially in the absence of Ku [39]. We will consider these possibilities in future work.…”
Section: Discussionmentioning
confidence: 89%
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“…In the current models only a single category of complex DSB has been considered. We expect that the localization of DSB in either euchromatin or heterochromatin may also play role in the biphasic profile, as proposed in [22], [57], and the slower repair of complex DSB may allow alternate pathways to compete for repair [3] especially in the absence of Ku [39]. We will consider these possibilities in future work.…”
Section: Discussionmentioning
confidence: 89%
“…We used the gradient method to search for the appropriate values of the involving parameters such that the numerical simulation of the model has a good fit to the experimental data related to the kinetics of formation of Ku80-EGFP and DNA-PKcs-YFP at sites of DNA damage induced by ultrasoft X-rays (USX) or multi-photon IR induced laser light described in [1]. Whereas USX produce mainly simple DSB, the high powers generally used with NIR lasers result in a high density of damage, as discussed in reference [36], in the range of high LET charge particles as also suggested by Splinter et al [37] and previously proposed from laser studies [38], [39]. By fixing all the parameters except those related to ATM, the model also fits the data when an ATM inhibitor is used to retard the phosphorylation and hence release of DNA-PKcs.…”
Section: Introductionmentioning
confidence: 84%
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“…Though it has proven difficult to precisely assay the lesion composition produced by multiphoton applications (39, 58, 59), a mixture of damage would allow the repair of a number of pathways to be examined, though the most frequently reported applications are for DSB repair (7, 10). Three specific applications of multiphoton excitation to BER and SSB repair are reviewed here, but several studies using wavelength from 775-1050 nm have reported recruitment of XRCC1 to sites of damage, although this was most often utilized as a marker of SSBs (57, 60).…”
Section: Near Infrared (Nir) Wavelengths Induces Ssbs and Oxidativmentioning
confidence: 99%
“…The fields most impacted by the advances in micro-irradiation have been NER and DSB repair (4-7, 10, 11). However, a growing number of studies have been examining the response of DNA repair factors to the sites of SSBs and oxidatively-induced base lesions (12-27).…”
Section: Introductionmentioning
confidence: 99%