Laser mass spectrometry of diquaternary ammonium salts

Dang, Tuan A.; Day, Richard E.; Hercules, David M.

doi:10.1021/ac00270a003

Cited by 34 publications

(18 citation statements)

References 15 publications

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“…We are unaware of any publication that contains the mass spectrum of paraquat obtained with direct laser desorption/ionization. Dang and co‐workers used laser desorption mass spectrometry to obtain mass spectra of a series of diquaternary ammonium salts 33. None of the test analytes generated doubly charged molecular ions.…”

Section: Resultssupporting

confidence: 65%

Laser desorption/ionization coupled to tandem mass spectrometry for real-time monitoring of paraquat on the surface of environmental particles

Lazar

Reilly

Whitten

et al. 2000

Rapid Commun. Mass Spectrom.

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Section: Resultssupporting

confidence: 65%

Laser desorption/ionization coupled to tandem mass spectrometry for real-time monitoring of paraquat on the surface of environmental particles

Lazar

Reilly

Whitten

et al. 2000

Rapid Commun. Mass Spectrom.

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“…Typically, the formation of precursor ions containing two or more molecules is not observed in TOF LMMS as opposed to, e.g., SIMS, plasma desorption MS, field desorption, and fast atom bombardment MS (112). Exceptions are limited to a few lower analogs (101,113). This result can be related to the dependence of the selvedge density on the "volatility" of the analyte.…”

Section: Current Concepts About Ion Formationmentioning

confidence: 99%

Organic and inorganic analysis with laser microprobe mass spectrometry. Part I: Instrumentation and methodology

Vaeck

Struyf

Roy

et al. 1994

Mass Spectrometry Reviews

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“…Quaternary ammonium salts are popular test compounds that have been studied by various soft mass spectrometric techniques,1–10 since the presence of fixed ‘preformed’ charges in their organic cations facilitates investigations on the fundamentals of ion generation and on fragmentation pathways. In our previous studies11–17 we selected the bisquaternary ammonium compound decamethoxinum as a structure and energy probe for soft ionization methods, because it demonstrated a strong dependence of the types of ions recorded in the mass spectra on the mass spectrometric technique and experimental conditions applied.…”

mentioning

confidence: 99%

The effect of cone voltage on electrospray mass spectra of the bisquaternary ammonium salt decamethoxinum

Pashynska

Kosevich

Heuvel

et al. 2006

Rapid Comm Mass Spectrometry

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The effect of cone voltage (CV) variation on the mass spectral pattern of the bisquaternary ammonium salt decamethoxinum in the electrospray ionization (ESI) mode was studied. The advantage of decamethoxinum as a test compound in ESI mass spectrometry lies in the production of two types of precursor ions, i.e. the doubly charged organic dication Cat 2R and its singly charged cluster with a Cl S counterion, Cat Á Cl R . This makes it possible to monitor the fragmentation patterns of these ions under identical experimental conditions. Pronounced qualitative and quantitative changes in the ESI mass spectra were observed upon a gradual increase of the CV. The model compound decamethoxinum allowed us to reveal the extreme situation, in which the mass spectra at a CV below and over approximately 100 V look quite different, in that they contain different product ions of Cat 2R and Cat Á Cl R . While this effect may be much less pronounced for other classes of organic compounds, it should be properly taken into account for the adequate description of fragmentation pathways of bisquaternary ammonium compounds with ESI. Comparison of ESI, FAB-SIMS and MALDI mass spectra of decamethoxinum shows that taking into account CV effects also permits us to gain information on energy deposition into ions generated with the different ionization techniques. 10,[37][38][39][40][41][42] It is believed that the CV effect is due to an in-source collision-induced dissociation (CID) (up-front CID) process. The initially sprayed charged species can undergo collisions with the residual or bath gas on their path between the nozzle and the skimmer, and the change of the ion velocity caused by CV variation affects their kinetic energy and, consequently, their collision energy. 18The possibility of controlling the charge state of the ions, the desolvation process and the degree of fragmentation of the ions by CV variation offers the prospect of many useful applications of this technique, mainly in studies of supramolecular noncovalent complexes. [25][26][27][28][29][30][31][32][33][34][35][36] For example, a method was suggested for evaluating the stability of chemotherapeutic non-intercalating drugs binding to DNA on the basis of monitoring DNA-drug complex decomposition upon CV increase, which correlates with the thermal decomposition of the complex. 25,26 CV adjustment is also of critical importance in probing the structures of surfactant micelles generated under ESI conditions. 30,31 In-source CID is used along with collision-cell tandem mass spectrometric (MS/MS) CID in studies of protein structures. [19][20][21][32][33][34][35][36] Comparison of in-cell CID and in-source CID 32 permits us to obtain more comprehensive information on the molecular structures of analytes. A method, denoted as energydependent ESI mass spectrometry (EDESI-MS), employing CV variation, has been reported for fragmentation studies of metalloorganic compounds.

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Laser mass spectrometry of diquaternary ammonium salts

Cited by 34 publications

References 15 publications

Laser desorption/ionization coupled to tandem mass spectrometry for real-time monitoring of paraquat on the surface of environmental particles

Laser desorption/ionization coupled to tandem mass spectrometry for real-time monitoring of paraquat on the surface of environmental particles

Organic and inorganic analysis with laser microprobe mass spectrometry. Part I: Instrumentation and methodology

The effect of cone voltage on electrospray mass spectra of the bisquaternary ammonium salt decamethoxinum

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