Laser-Microstructured Double-Sided Adhesive Tapes for Integration of a Disposable Biochip

Abstract

Laser-microstructured double-sided biocompatible adhesive tapes as intermediated bonding layers are potential candidates for hybrid integration of a disposable biochip. In the EU-PHOCNOSIS project, such thin adhesive tapes are proposed to integrate the polymer microfluidic system with the optical sensor chip. Three laser-assisted structuring methods are investigated to efficiently transfer microchannel patterns to the adhesive tape at room temperature. The test structure design consists of a single channel with 400 µm wide, 30 mm length and two circular receivers with 2 mm radius. The best structuring results are found by using a UV picosecond laser.

Microfluidic flow-cell with passive flow control for microscopy applications

“…From our experience, the minimal channel width that can be fabricated, in adhesive tape, with a programmable mechanical cutting blade is~500 μm. A recent demonstration showed that a laser cutter can be used to make channels in adhesive tape with widths down to~100 μm [20].…”

Portable Diagnostic Platform for Detection of Microorganisms Coliforms and <i>E. coli</i>

“…The materials used in the construction of our portable culture platform combine durability, resistance to different temperatures, and can be sterilized in an autoclave, without compromising its integrity [35]. The use of adhesive tape provides the device's architecture, provides structural support for the paper, simplifies the handling and ensures the containment of the analytical region [6] [20] [37]. The presence of two windows in the adhesive tape covered by PDMS films provides the necessary gas flow for bacterial development, ensuring the diagnostic platform functionality [20] [38].…”

High-throughput microbead assay system with a portable, cost-effective Wi-Fi imaging module, and disposable multi-layered microfluidic cartridges for virus and microparticle detection, and tracking

“…These newer microfabrication strategies are being implemented using novel designs, appropriate selection of materials, and operating at the limits of common microfabrication technologies. Laser micromachining of DSA is an interesting approach for the fabrication of biomedical devices as it allows the creation of hybrid structures using polymers, thermoplastics, elastomers, glass, silicon, hydrogels, resins and other transparent/translucent substrates for optical readout (Zamora et al 2017; Tsao and Syu 2020; Cooksey and Atencia 2014). One recent review article that illustrates this expansion is presented by Ingber (Ingber 2022), detailing the approaches for the expansion of micro uidics into more complex platforms such as human organs-on-chips and personalized medicine that allow drug approaches have been proposed, for example: antibody-functionalized gold nanoparticles and enhanced surface plasmon resonance (SPR) techniques were reported as a method to detect SARS-CoV-2 nucleocapsid protein, but specialized tools such as a SPR system and scanning electron microscope (SEM) are required for data analysis (Yano et al 2022).…”