Laser Regeneration of Spine Discs Cartilage: Mechanism, In-Vivo Study and Clinical Applications

Sobol, Emil N.; Басков, А В; Shekhter, Anatoly B.; Borshchenko, Igor; Захаркина, О. Л.

doi:10.1007/978-0-387-71809-5_24

Cited by 10 publications

(16 citation statements)

References 11 publications

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“…The pore formation in cartilage under mechanical load and laser heating was also experimentally studied. 55,56,59 It was shown that laser heating increased both a number of pores and their size in a controllable manner (Fig. 4).…”

Section: Characteristic Features and Physical Mechanisms Of Laser-indmentioning

confidence: 94%

“…55 One of the essential mechanisms of laser-induced cartilage regeneration is pore "unblocking;" their rearrangement and formation of new pores due to thermo mechanical effect of laser radiation. 56 Nonuniform heating of the tissue under spatial and temporal modulated laser radiation leads to heterogeneous deformation and stress, which may induce development of gas bubbles and the pores in ESM. 57 The theoretical model based on analysis of the heat activated chemical bonds breaking, describes stress relaxation due to formation of the pores in cartilage matrix under thermal/mechanical load.…”

Section: Characteristic Features and Physical Mechanisms Of Laser-indmentioning

confidence: 99%

“…Longterm stability of the positive outcomes of LRD and the growth of hyaline-like cartilage in laser treated zones of spine disks was confirmed in human studies as was previously established in the animal models. 55,56,79 The above characteristics of LRD are advantageous compared to other minimal invasive techniques of spine diseases treatment, which mainly provide heating of the AF and denervation of the disks. Laser wavelength and other characteristics for LRD have been chosen to locally heat NP in the bulk of about 1 mm 3 up to temperatures of about 50…”

Section: Laser Reconstruction Of Spine Disksmentioning

confidence: 99%

“…[55][56][57] The expansion of locally heated tissue provides thermo mechanical stress at a distance of about a few millimeters from the zone of laser irradiation. LRD results in the formation of well-organized hyaline-like tissue, probably because the effect of laser radiation in the course of LRD is mild enough.…”

Section: Laser Reconstruction Of Spine Disksmentioning

confidence: 99%

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Laser-induced regeneration of cartilage

et al. 2011

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Abstract. Laser radiation provides a means to control the fields of temperature and thermo mechanical stress, mass transfer, and modification of fine structure of the cartilage matrix. The aim of this outlook paper is to review physical and biological aspects of laser-induced regeneration of cartilage and to discuss the possibilities and prospects of its clinical applications. The problems and the pathways of tissue regeneration, the types and features of cartilage will be introduced first. Then we will review various actual and prospective approaches for cartilage repair; consider possible mechanisms of laser-induced regeneration. Finally, we present the results in laser regeneration of joints and spine disks cartilages and discuss some future applications of lasers in regenerative medicine. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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Section: Characteristic Features and Physical Mechanisms Of Laser-indmentioning

confidence: 94%

Section: Characteristic Features and Physical Mechanisms Of Laser-indmentioning

confidence: 99%

Section: Laser Reconstruction Of Spine Disksmentioning

confidence: 99%

Section: Laser Reconstruction Of Spine Disksmentioning

confidence: 99%

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Laser-induced regeneration of cartilage

et al. 2011

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“…The pore formation in cartilage under mechanical load and laser heating was studied experimentally. 24,26,27 It was shown that laser heating increased both the number of pores and their size in a controllable manner. These pores intensifi ed mass transfer of water in the ESM and improved the nutrition of the cells.…”

Section: Special Features Of Laser Regenerationmentioning

confidence: 98%

Lasers in orthopaedic surgery

Sobol

Shekhter

Baskov³

2013

Lasers for Medical Applications

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Laser radiation effect on chondrocytes and intercellular matrix of costal and articular cartilage impregnated with magnetite nanoparticles

et al. 2015

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It was shown that SSNPs do not appreciably affect the structural components of both articular and costal cartilage and can be safely used for the laser diagnostics and therapy. The area of structural alterations is diffuse and local as the result of the mechanical and heat effect of laser impact. SSNPs reveal the areas of the structural alterations of cartilage matrix and give information about the size of the pores and defects.

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Laser Regeneration of Spine Discs Cartilage: Mechanism, In-Vivo Study and Clinical Applications

Cited by 10 publications

References 11 publications

Laser-induced regeneration of cartilage

Laser-induced regeneration of cartilage

Lasers in orthopaedic surgery

Laser radiation effect on chondrocytes and intercellular matrix of costal and articular cartilage impregnated with magnetite nanoparticles

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