Laser Scanning Tomography of the Optic Nerve Head in a Normal Elderly Population: The Bridlington Eye Assessment Project

Abstract

To the authors' knowledge, this is the first large study of optic nerve head parameters in the elderly normal population using the HRT II. This age range is particularly relevant to glaucoma detection and pertinent to discriminant analyses separating normal subjects from glaucoma in screening for the disease. Given the systematic differences between the parameters in men and women, reference ranges should be quoted by sex.

The relationship between central corneal thickness and the optic disc in an elderly population: the Bridlington Eye Assessment Project

“…Our sample of nearly 700 eyes from 700 persons analysing CCT against HRT should therefore include eyes that will be progressing towards glaucomatous field loss. The number of ONHs in the sample has been sufficient to demonstrate systematic differences in HRT2 parameters between elderly men and women in one of our previous publications, 14 former of which have twice the prevalence of the disease. 15 Thus, the absence of any relationship between global HRT2 parameters and CCT in this study suggests that if a larger study found a relationship, it would likely be of little clinical significance (the finding of two statistically significant associations in the 72 sectoral analyses of CCT vs HRT2 parameters would be expected by chance in a study with large numbers such as ours and is also of no clinical significance).…”

“…The exclusion of 30% of subjects due to poor HRT2 image quality is unfortunately an inevitable consequence of a study such as this. This issue has been discussed previously, 14 and represents the reduction in image quality with increasing age, and is due to a number of factors including lens clarity. However, there was no significant difference in CCT and age between those included and excluded on the grounds of HRT quality.…”

“…14 Briefly, the project is a screening exercise for eye disease in patients over 65 years of age. Approximately 6500 such subjects registered with the general practitioners in the town of Bridlington, England were systematically invited to attend an extensive eye examination performed by one of four optometrists trained specifically for the project.…”

“…This study presents data obtained from subjects screened by the Bridlington Eye Assessment Project (BEAP) 14 effectively, a screening programme for ocular disease in elderly white subjects. The aim of the current study was to determine population-based normative CCT data for elderly white subjects both with and without diabetes, and to explore the relationship between CCT and IOP and HRT2 measurements in such subjects with normal visual fields.…”

Predictive Value of Heidelberg Retina Tomograph Parameters for the Development of Glaucoma in the European Glaucoma Prevention Study

“…Rim and cup areas are significantly correlated with disc area in normal eyes, both in morphometric studies 44,45 and in HRT studies. 46,47,[55][56][57][58] This suggests that both cup area and rim area should increase their predictive value for the development of OAG by taking disc area into account.…”