Superior segmental optic nerve hypoplasia in youth

Takagi, Mineo; Abe, Haruki; Hatase, Tetsuhisa; Yaoeda, Kiyoshi; Miki, Atsushi; Shirakashi, Masataka

doi:10.1007/s10384-008-0588-9

Cited by 10 publications

(15 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, not all of these features could be consistently found in other reports 6,8–10. Instead, a double-ring sign, which is a hallmark of optic hypoplasia, has been found 10. Also, while previous reports from Western countries have demonstrated that SSOH is frequently associated with maternal type 1 diabetes mellitus, reports from Japan and Korea have not supported this association 10,12.…”

Section: Introductionmentioning

confidence: 79%

“…Instead, a double-ring sign, which is a hallmark of optic hypoplasia, has been found 10. Also, while previous reports from Western countries have demonstrated that SSOH is frequently associated with maternal type 1 diabetes mellitus, reports from Japan and Korea have not supported this association 10,12. Thus, the definition of SSOH remains obscure, and it may possibly consist of multiple optic nerve anomalies.…”

Section: Introductionmentioning

confidence: 97%

“…Kim et al have shown four characteristic findings concerning the optic disc, ie, a relative superior entrance of the central retinal artery, a superior peripapillary scleral halo, pallor of the superior disc, and a thinning of the superior peripapillary nerve fiber layer 4. However, not all of these features could be consistently found in other reports 6,8–10. Instead, a double-ring sign, which is a hallmark of optic hypoplasia, has been found 10.…”

Section: Introductionmentioning

confidence: 97%

“…The term “superior segmental optic nerve hypoplasia” (SSONH), which is preferred by some investigators, has also sometimes been used instead of SSOH, because the clinical features of this entity include not only a morphologic optic disc anomaly, but also optic nerve fiber defects 10,12. SSOH is considered to be a type of optic nerve hypoplasia, but is unusual in that the central visual acuity is spared.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Optic nerve head analysis of superior segmental optic hypoplasia using Heidelberg retina tomography

Miki

Shirakashi²,

Yaoeda³

et al. 2010

OPTH

Self Cite

View full text Add to dashboard Cite

PurposeTo evaluate the optic disc characteristics of eyes with superior segmental optic hypoplasia (SSOH) using the Heidelberg retina tomograph (HRT).Patients and methodsThirteen eyes of 13 Japanese patients with SSOH were studied with the HRT (software version: 3.0). The group included six males and seven females, with a mean age of 34.7 years. Six optic disc parameters in the six sectors derived from the patients with SSOH were compared with those of 13 eyes of 13 normal controls. In addition, the diagnostic classification performance of the Frederick S Mikelberg (FSM) discriminant function, glaucoma probability score (GPS), and Moorfields regression analysis (MRA) were assessed.ResultsWhen compared with normal subjects, many of the optic disc parameters were significantly altered in SSOH in the superior sectors. The area under the curve (AUC) for the receiver operating characteristic was 0.932 for the rim area, 0.926 for the cup-to-disc area ratio, and 0.882 for the cup shape measure. Among the HRT parameters, the largest AUC (0.988) was found for the cup shape measure in the nasal superior segment. The proportion classified as outside normal limits by the FSM discriminant function was 92.3% (12 eyes). For GPS, six eyes (46.2%) were classified as outside normal limits. For MRA, when borderline cases were considered test-negative or test-positive, 10 eyes (76.9%) or 11 eyes (84.6%) were classified as outside normal limits, respectively. The AUCs were 0.976 for the FSM discriminant function, 0.914 for the MRA overall classification, and 0.710 for the GPS overall classification.ConclusionsIn eyes with SSOH, there is a significant thinning of the rim, especially in the nasal superior sector. Approximately half of the eyes with SSOH were classified as abnormal using indices developed for detecting glaucoma, but the sectorial analysis revealed that the affected sectors were different from those of glaucoma. Optic nerve head measurements using the HRT may be useful in evaluating the optic disc characteristics in eyes with SSOH.

show abstract

Section: Introductionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Optic nerve head analysis of superior segmental optic hypoplasia using Heidelberg retina tomography

Miki

Shirakashi²,

Yaoeda³

et al. 2010

OPTH

Self Cite

View full text Add to dashboard Cite

show abstract

“…The typical disc morphology of SSOH may incorrectly lead to a diagnosis of NTG or JOAG, especially if the IOP is considered borderline. Takagi et al proposed several key differences between SSOH from NTG: in SSOH, visual fields show no Bjerrum scotoma, disc cupping is not classically glaucomatous and can be out of proportional to the severity of the visual field defect [2]. RNFL defects in SSOH have a sectored pattern, in contrast to the localized slit-like pattern found in NTG [3].…”

Section: Discussionmentioning

confidence: 99%

Comparing Structure-Function Correlations in Superior Segmental Optic Nerve Hypoplasia and Juvenile Open Angle Glaucoma Using Spectral-Domain Optical Coherence Tomography

Suwannaraj¹,

Cavuoto²,

Chang³

2015

J Clin Exp Ophthalmol

View full text Add to dashboard Cite

Superior segmental optic nerve hypoplasia (SSOH) is a congenital anomaly of the optic nerve that is commonly misdiagnosed as normal tension glaucoma (NTG) and/or juvenile open angle glaucoma (JOAG). We demonstrate the utility of SD-OCT in assessing the structure-function correlation when differentiating between SSOH and JOAG.Keywords Superior segmental optic nerve hypoplasia; Glaucoma; Imaging; Retinal nerve fiber layer optical coherence tomography Case Report Case 1A 13 year-old male with a history of an increased cup-to-disc ratio of the left eye was referred for evaluation of JOAG. He had no family history of glaucoma. On examination, his visual acuity was 20/25 in both eyes. Applanation tonometry revealed an intraocular pressure (IOP) of 14 mmHg on the right without treatment and 12 mmHg on the left with topical beta-blocker treatment. Records of the IOP prior to presentation and treatment were unavailable.Gonioscopy showed open angles in both eyes. Fundus examination revealed a normal optic disc with a superior peripapillary scleral halo in the right eye and superior disc pallor with thinning of the superior rim in the left eye (Figure 1a). A Humphrey visual field 24-2 (Carl Zeiss Meditec, Dublin, CA) showed an inferior field defect in left eye (Figure 1b), while SD-OCT showed RNFL thinning superiorly ( Figure 1c). The patient was diagnosed with SSOH of the left eye and was instructed to discontinue the topical beta-blocker. In twenty months of follow up, the untreated IOP has remained within physiologic range and serial visual fields and SD-OCT RNFL analyses have remained stable on two subsequent tests.

show abstract

Clinical features of superior segmental optic hypoplasia: hospital-based study

et al. 2018

View full text Add to dashboard Cite

Superior segmental optic nerve hypoplasia in youth

Abstract: Characteristic VFD patterns on Goldmann perimetry and corresponding NFLDs are important in the diagnosis of SSOH, but not optic disc morphology.

Cited by 10 publications

References 24 publications

Optic nerve head analysis of superior segmental optic hypoplasia using Heidelberg retina tomography

Optic nerve head analysis of superior segmental optic hypoplasia using Heidelberg retina tomography

Comparing Structure-Function Correlations in Superior Segmental Optic Nerve Hypoplasia and Juvenile Open Angle Glaucoma Using Spectral-Domain Optical Coherence Tomography

Clinical features of superior segmental optic hypoplasia: hospital-based study

Contact Info

Product

Resources

About