Clinical features of superior segmental optic hypoplasia: hospital-based study

Yagasaki, Ayaka; Sawada, Akira; Manabe, Yusuke; Yamamoto, Tetsuya

doi:10.1007/s10384-018-0634-1

Cited by 8 publications

(7 citation statements)

References 21 publications

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“…Previously, we used laser speckle flowgraphy to show that SSOH, a congenital anomaly, causes reduced microcirculation in the ONH [5], that the quadrant MT ratios in the ONH have a strong power to differentiate SSOH and NTG (indicating that SSOH has a fundamentally different pathogenesis from NTG) [5], and that the structure of the deep layers of the ONH, around the lamina cribrosa, are correlated to MT, but not RPC density [6]. Here, we found that the density of the peripapillary retinal microvasculature decreased in SSOH, but that the pattern of RPC loss was distinctly different from that reported for cpRNFLT [3]. RPC density in the 9 o'clock sector, outside the temporal area, was significantly lower, but RPC density in the 3 o'clock sector was not significantly different in the SSOH and normal subjects.…”

Section: Discussioncontrasting

confidence: 44%

“…In Asia, normal-tension glaucoma (NTG) is the primary subtype of open-angle glaucoma [1] making it important to differentiate SSOH from NTG [2]. Previously, it was reported that SSOH could be identified based on the location of cpRNFLT loss [3] and structural abnormalities in the extension of the retinal pigment epithelium (RPE) over the nasal disc margin [4], both measured with spectral-domain optical coherence tomography (OCT). Thus, both fundus photography and OCT may be useful in the clinical treatment of SSOH.…”

Section: Introductionmentioning

confidence: 99%

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Radial peripapillary capillary density in superior segmental optic hypoplasia measured with OCT angiography

et al. 2020

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Background: To investigate the diagnostic power of radial peripapillary capillary (RPC) density, measured with optical coherence tomography angiography (OCT-A), in patients with superior segmental optic hypoplasia (SSOH). Methods: Forty subjects with SSOH and 40 age-and axial length-matched control subjects were retrospectively registered for this study. SSOH was defined as intraocular pressure less than 21 mmHg with the presence of two of the following: superior rim thinning, superior entrance of the central retinal artery, scleral halo, and pale optic disc; as well as non-progressive visual field loss. RPC density was measured with swept-source OCT-A (Triton, Topcon) overall, in the quadrants, and in the 12 clockwise sectors. Changes in RPC density were also compared in SSOH patients and age-matched patients with mild-or moderate-stage of glaucoma. RPC density was compared in pairs of groups with Welch's t-test. Diagnostic power was assessed with the area under the receiver operating characteristics curve (AUC). Results: Overall cpRNFLT was significantly different in the normal (106.7 ± 9.5 μm) and SSOH (77.2 ± 13.7 μm, p < 0.001) subjects. RPC density overall and in the superior, nasal, and inferior quadrants was significantly lower in the SSOH group (all, p < 0.001), but not in the temporal (p = 0.756) quadrant. The diagnostic power of RPC density was highest in the superior quadrant (AUC = 0.928) and the 1 o'clock sector (0.896). Comparing the SSOH and glaucoma patients showed that there were no significant differences in RPC density either overall (p = 0.391) or in the superior quadrant (p = 0.268), while RPC density was significantly higher in the inferior (p = 0.005) and temporal quadrants (p < 0.001) and lower in the nasal quadrant (p = 0.029). Conclusions: Low RPC density was found in the three non-temporal quadrants of the optic nerve head in SSOH patients, in comparison to normal subjects. Regionally, RPC density in SSOH was lower in the nasal quadrant and higher in the inferior and temporal quadrants in comparison to glaucoma patients. Measuring RPC density with OCT-A may help the diagnosis of SSOH and may improve the management of glaucoma.

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Section: Discussioncontrasting

confidence: 44%

Section: Introductionmentioning

confidence: 99%

Radial peripapillary capillary density in superior segmental optic hypoplasia measured with OCT angiography

et al. 2020

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show abstract

“…Previously, we used laser speckle flowgraphy to show that SSOH, a congenital anomaly, causes reduced microcirculation in the ONH (5), that the quadrant MBR ratios in the ONH have a strong power to differentiate SSOH and NTG (indicating that SSOH has a fundamentally different pathogenesis from NTG) (5), and that the structure of the deep layers of the ONH, around the lamina cribrosa, are correlated to MT, but not RPC density (6). Here, we found that the density of the peripapillary retinal microvasculature decreased in SSOH, but that the pattern of RPC loss was distinctly different from that reported for cpRNFLT (3). RPC density in the 9 o'clock sector, outside the temporal area, was significantly lower, but RPC density in the 3 o'clock sector was not significantly different in the SSOH and normal subjects.…”

Section: Discussioncontrasting

confidence: 41%

“…In Asia, normal-tension glaucoma (NTG) is the primary subtype of openangle glaucoma (1) making it important to differentiate SSOH from NTG (2). Previously, it was reported that SSOH could be identified based on the location of cpRNFLT loss (3) and structural abnormalities in the extension of the retinal pigment epithelium (RPE) over the nasal disc margin (4), both measured with spectral-domain optical coherence tomography (OCT). Thus, both fundus photography and OCT may be useful in the clinical treatment of SSOH.…”

Section: Introductionmentioning

confidence: 99%

Radial peripapillary capillary density in superior segmental optic hypoplasia measured with OCT angiography.

Abe

Omodaka

Kikawa

et al. 2019

Preprint

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Background: To investigate the diagnostic power of radial peripapillary capillary (RPC) density, measured with optical coherence tomography angiography (OCT-A), in patients with superior segmental optic hypoplasia (SSOH), a disease which is important to differentiate from glaucoma. Methods: Forty subjects with SSOH and 40 age- and axial length-matched control subjects were retrospectively registered for this study. SSOH was defined as intraocular pressure (IOP) less than 21 mmHg with the presence of two of the following: superior rim thinning, superior entrance of the central retinal artery, scleral halo, and pale optic disc; as well as non-progressive visual field loss. RPC density was measured with swept-source OCT-A (Triton, Topcon) in the overall, quadrants, and 12 clock-wise sectors. RPC density was compared in normal and SSOH subjects with Welch’s t-test. Diagnostic power was assessed with the area under the receiver operating characteristics curve. Results: Overall cpRNFLT was significantly different in the normal (106.7 ± 9.5 μm) and SSOH (77.2 ± 13.7 μm, p < 0.001) subjects. RPC density in the overall area (p < 0.001) and superior (p < 0.001), nasal (p < 0.001), and inferior (p < 0.001) quadrants was significantly lower in the SSOH group, but not in the temporal (p = 0.756) quadrant. The diagnostic power of RPC density was highest in the superior quadrant (AUC = 0.928) and the 1 o’clock sector (0.896). Conclusions: Low RPC density was found in the three non-temporal quadrants of the optic nerve head. Measuring RPC density with OCT-A may help the diagnosis of SSOH and may improve the management of glaucoma.

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“…We investigated the prevalence and characteristics of SSOH in 14,779 individuals, aged 40 years or older, who participated in a large-scale eye disease screening project conducted in Tajimi, Japan, between September 2000 and October 2001, designated Study 1. [4] The project was comprised of two study populations: one consisted of 4000 randomly selected citizens, aged 40 years or older, who underwent a detailed ophthalmological checkup as part of the well-known Tajimi study;[6] the other consisted of a screening of the general population. In the latter, the following ophthalmological examinations were conducted for both eyes: visual acuity testing, refractometry with a refractometer, corneal thickness measurement, frequency-doubling technology (FDT) perimetry, 45° fundus photography, Goldmann applanation tonometry, slit-lamp biomicroscopy, and van Herick testing.…”

Section: Outlines Of Our Previous Studiesmentioning

confidence: 99%

Superior segmental optic hypoplasia as a differential diagnosis of glaucoma

Yamamoto

2019

Taiwan J Ophthalmol

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Superior segmental optic hypoplasia (SSOH) is a congenital anomaly affecting the optic nerve head and retina. Although the conventional characterization of SSOH emphasizes the relatively superior entrance of the central retinal artery, the pallor of the superior optic disc, a superior peripapillary halo, and thinning of the superior nerve fiber layer, we encounter many cases with rim thinning in the superior nasal region that corresponds to a nerve fiber layer defect and an inferior wedge-shaped visual field defect connecting to the blind spot. However, among Asians, such cases usually lack pallor of the superior optic disc and more resemble glaucomatous optic neuropathy. We found the prevalence of SSOH to be 0.2%/eye and 0.3%/case among Japanese. We also noted that approximately half of all SSOH eyes show visual field changes. SSOH is an important differential diagnosis of glaucoma, especially normal-tension glaucoma, in Asian populations.

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Clinical features of superior segmental optic hypoplasia: hospital-based study

Cited by 8 publications

References 21 publications

Radial peripapillary capillary density in superior segmental optic hypoplasia measured with OCT angiography

Radial peripapillary capillary density in superior segmental optic hypoplasia measured with OCT angiography

Radial peripapillary capillary density in superior segmental optic hypoplasia measured with OCT angiography.

Superior segmental optic hypoplasia as a differential diagnosis of glaucoma

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