Problem statement: Secure methods for blood sampling which is performed at present by metallic lancets, has been a concern in the modern medicine in order to diminish the risk of contamination. A novel solution has appeared recently and consists in the use of laser pulses which ablates a tiny hole in skin. Approach: A laser device with Er: YAG active medium for skin perforation with focal point detection by light wall, is presented in this work. Results: This device permits the capture of blood samples without any mechanical contact with human skin. It includes a pulsed Er:YAG laser emitting at 2.94 nm and a sensor which determine the focal point of laser light on the skin surface in order to optimize the hole dimensions between 40 and 60 µm by using pulses with energy between 300 mJ and 550 mJ according the skin thickness. Conclusions: This new device allows to eliminate the use of metallic lancets that cause pain and can provoke the diseases transmission.