Laser treatments on skin enhancing and controlling transdermal delivery of 5‐fluorouracil

Gómez, Clara; Costela, Á.; García‐Moreno, Inmaculada; Llanes, Felipe; Teijón, José M.; Blanco, Dolores

doi:10.1002/lsm.20590

Cited by 62 publications

(31 citation statements)

References 15 publications

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“…Laser and Intense Pulsed Light (IPL) have been common tools for clinical cosmetic therapy [13], and also have been used to improve effectively drug or OCAs transepidermal delivery [14][15][16]. Tuchin et al [17] found that skin permeability could be effectively enhanced by creating an island of limited thermal damage using a flashlamp (IPL) system.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of skin optical clearing efficacy using photo‐irradiation

Liu¹,

Zhi²,

Tuchin³

et al. 2010

Lasers Surg Med

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Background and Objectives: Tissue optical clearing technique based on immersion of tissues into optical clearing agents (OCAs) can reduce the scattering and enhance the penetration of light in tissue. However, the barrier function of epidermis limits the penetration of OCAs, and hence is responsible for the poor optical clearing efficacy of skin by topical action. In this study, a variety of light irradiation was applied to increase permeability of agents in skin and improve the optical clearing efficacy. Study Design/Materials and Methods: Different light sources with different dose, i.e, CO 2 laser, Nd:YAG laser (532 and 1,064 nm) with different pulse modes and Intense Pulsed Light (IPL) (400-700 and 560-950 nm) were used to irradiate rat skin in vivo, and then glycerol was applied onto the irradiated zone. VIS-NIR spectrometer was utilized to monitor the changes of reflectance. In vitro skin samples were also irradiated by Q-switched Nd:YAG laser (1,064 nm) and then treated by glycerol for 10-60 minutes. Based on the measurement of the reflectance and transmittance of the samples, the optical properties of skin and penetration depth of light were calculated. Results: Results show that photo-irradiation with appropriate dose combining with the following glycerol treatment is able to reduce in vivo skin reflectance. Compared with the control group, the maximal changes in reflectance are ninefold at 575 nm and eightfold at 615 nm, respectively, which were caused by Q-switched 1,064-nm Nd:YAG laser irradiation and following glycerol treatment. The results for in vitro skin demonstrate that the joint action can significantly increase the optical penetration depth in samples. Conclusions: The combination of Q-switched Nd:YAG (1,064 nm) laser and glycerol could enhance optical skin clearing efficacy significantly. This study provides a noninvasive way to improve the optical clearing of skin, which will benefit the skin optical therapy.

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Section: Introductionmentioning

confidence: 99%

Enhancement of skin optical clearing efficacy using photo‐irradiation

Liu¹,

Zhi²,

Tuchin³

et al. 2010

Lasers Surg Med

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show abstract

“…These include the use of permeation enhancers, employing vesicular drug delivery systems, delivering hydrophilic drugs using microneedles, or augmenting transdermal flux using laser systems. [15][16][17][18][19][20][21][22][23][24] Microdermabrasion, which involves blowing of aluminum oxide crystals or other abrasive substances onto the face and then vacuuming them off, 24peels the stratum corneum, leading to better penetration of topical preparations.…”

Section: Discussionmentioning

confidence: 99%

Assessment of response of microdermabrasion with 2% kojic acid in melasma

Agarwal

2016

Int J Res Med Sci

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“…This laser capability has enabled the expansion of its applications to a wide range of bioengineering and biomedicine applications, such as surgery, treatment, drug screening, detection, diagnostics, drug delivery, and analysis [2][3][4][5][6][7][8][9][10][11][12][13]. There are several other advantages as follows.…”

Section: Introductionmentioning

confidence: 99%

Femtosecond Laser-Inscripted Direct Ultrafast Fabrication of a DNA Distributor Using Microfluidics

et al. 2017

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A femtosecond laser can be used for single or multiple writing processes to create sub 10-µm lines or holes directly without the use of masks. In this study, we characterized the depth and width of micro-channels created by femtosecond laser micro-scribing in polydimethylsiloxane (PDMS) under various energy doses (1%, 5%, 10%, 15% and 20%) and laser beam passes (5, 10 and 15). Based on a microfluidic simulation in a bio-application, a DNA distributor was designed and fabricated based on an energy dose of 5% and a laser beam pass of 5. The simulated depth and width of the micro-channels was 3.58 and 5.27 µm, respectively. The depth and width of the micro-channels were linearly proportional to the energy dose and the number of laser beam passes. In a DNA distribution experiment, a brighter fluorescent intensity for YOYO-1 Iodide with DNA was observed in the middle channels with longer DNA. In addition, the velocity was the lowest as estimated in the computational simulation. The polymer processability of the femtosecond laser and the bio-applicability of the DNA distributor were successfully confirmed. Therefore, a promising technique for the maskless fabrication of sub 10-µm bio-microfluidic channels was demonstrated.

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Laser treatments on skin enhancing and controlling transdermal delivery of 5‐fluorouracil

Cited by 62 publications

References 15 publications

Enhancement of skin optical clearing efficacy using photo‐irradiation

Enhancement of skin optical clearing efficacy using photo‐irradiation

Assessment of response of microdermabrasion with 2% kojic acid in melasma

Femtosecond Laser-Inscripted Direct Ultrafast Fabrication of a DNA Distributor Using Microfluidics

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