Laser-triggered intraocular implant to induce photodynamic therapy for posterior capsule opacification prevention

Zhang, Zhaoguo; Huang, Wenyong; Lei, Ming; He, Yuanfeng; Yan, Mina; Zhang, Xuefei; Zhao, Chunshun

doi:10.1016/j.ijpharm.2015.10.006

Cited by 23 publications

(18 citation statements)

References 25 publications

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“…Even with the improved skills and new technologies, PCO still is the most common complication following an uneventful cataract surgery. Great efforts have been expended to reduce the rate of PCO, including pharmacologic measures, 21 , 22 surgical techniques, 31 devices, 23 – 28 preventive laser treatment, 32 , 33 IOL materials, 13 , 18 , 31 , 34 , 35 and IOL designs. 12 – 19 , 36 Adding a sharp posterior edge to IOLs has reduced significantly the PCO rates and the subsequent need for Nd:YAG laser capsulotomy.…”

Section: Discussionmentioning

confidence: 99%

Further Enhancement of Intraocular Open-Capsule Devices for Prevention of Posterior Capsule Opacification

Slutzky

Kleinmann

2018

Trans. Vis. Sci. Tech.

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PurposeWe improve the intraocular open-capsule devices (IOCD) for the prevention of posterior capsule opacification (PCO).MethodsA total of 45 New Zealand rabbit eyes were divided into six similar groups after crystalline lens evacuation. Each group was implanted with a hydrophilic intraocular lens (IOL) and a hydrophilic IOCD of different designs. In the first experiment (Part A), a square design ring with and without large apertures was compared to a round design ring without apertures. In the second experiment (Part B), a square design ring with large apertures was compared to square design IOCDs with small apertures of high and low density. PCO and Soemmering's ring were evaluated clinically, by the Miyake Apple view, and histologically. The results were compared to a control group of eyes implanted with a hydrophilic IOL only.ResultsAll devices showed significant prevention of PCO and Soemmering's ring compared to the control group. Part A: the square design with apertures had the lowest level of peripheral lens epithelial cells proliferation (protrusions). Part B: modifying the size and density of the apertures had no influence on those protrusions.ConclusionsThe IOCD significantly reduced the rate of PCO and its precursor, Soemmering's ring. The rings with the square edges and apertures produced the best results. The study was underpowered to determine the influence of the apertures design.Translational RelevanceThe IOCD has the potential to prevent up to 80% of the PCO cases; the most common complication after cataract surgery. The design of the ring is important for its success.

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Section: Discussionmentioning

confidence: 99%

Further Enhancement of Intraocular Open-Capsule Devices for Prevention of Posterior Capsule Opacification

Slutzky

Kleinmann

2018

Trans. Vis. Sci. Tech.

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“…To date, much effort has been devoted to develop intraocular lens (IOLs), e.g., irrigating with chemical drugs, or genes, which can be in situ released to inhibit LECs proliferation after surgery. However, the released free drugs/genes have serious toxicity to other normal cells,[8c,10] which limit the clinical trial. Some modifications of the lens based on shape feature, hydrophilic–hydrophobic property, et al are less therapeutic effect on PCO.…”

Section: Methodsmentioning

confidence: 99%

Photothermal Ring Integrated Intraocular Lens for High‐Efficient Eye Disease Treatment

Lin

Zhao

et al. 2017

Advanced Materials

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Posterior capsule opacification (PCO) is the most common complication after cataract surgery. So far, the only method for PCO treatment is the precisely focused laser surgery. However, it causes severe complications such as physical damages and neuron impairments. Here, a nanostructured photothermal ring integrated intraocular lens (Nano-IOLs) is reported, in which the rim of commercially available IOLs (C-IOLs) is decorated with silica coated Au nanorods (Au@SiO ), for high-efficient prevention of PCO after cataract surgery. The Nano-IOLs is capable of eliminating the residual lens epithelial cells (LECs) around Nano-IOLs under mild laser treatment and block the formation of disordered LECs fibrosis, which eventually leads to the loss of vision. The Nano-IOLs shows good biocompatibility as well as extraordinary region-confined photothermal effect. In vivo studies reveal that PCO occurrence in rabbit models is about 30%-40% by using Nano-IOLs, which is significantly lower than the control group that treated with C-IOLs (100% PCO occurrence) 30 d postsurgery. To the best of our knowledge, it is the first example to integrate nanotechnology with intraocular implants aiming to clinically relevant PCO. Our findings indicate that spatial controllability of photothermal effect from nanomaterials may provide a unique way to intervene the PCO-induced loss of vision.

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“…Several methods have been suggested to produce coatings on drug-eluting biomedical devices (e.g., layer-by-layer deposition, spray coating, dip coating, plasma-assisted grafting) with the purpose of implementing drug-eluting reservoirs [64][65][66][67][68][69][70][71][72][73]. Besides, these coatings may be used in order to increase the hydrophilicity of the device surface [74] and, also, as diffusion barriers to drug release [75][76][77]. The main concern with the design of coatings to be applied onto CLs or IOLs is the preservation of the optical properties of the original lenses.…”

Section: Coatingmentioning

confidence: 99%

“…Zhang et al [77] obtained the laser-triggered release of indocyanine green, a photosensitizer, from commercially available IOLs by spray-coating the active agent on the lens surface and, subsequently, controlling the release with a sealing layer of PLGA. However, low transmittance, related to both the presence of indocyanine green and to PLGA degradation, remained an issue over several weeks after immersion in PBS, affecting the suitability of the system for the intended ocular application.…”

Section: Cataractmentioning

confidence: 99%

Therapeutic Ophthalmic Lenses: A Review

2020

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An increasing incidence of eye diseases has been registered in the last decades in developed countries due to the ageing of population, changes in lifestyle, environmental factors, and the presence of concomitant medical conditions. The increase of public awareness on ocular conditions leads to an early diagnosis and treatment, as well as an increased demand for more effective and minimally invasive solutions for the treatment of both the anterior and posterior segments of the eye. Despite being the most common route of ophthalmic drug administration, eye drops are associated with compliance issues, drug wastage by lacrimation, and low bioavailability due to the ocular barriers. In order to overcome these problems, the design of drug-eluting ophthalmic lenses constitutes a non-invasive and patient-friendly approach for the sustained drug delivery to the eye. Several examples of therapeutic contact lenses and intraocular lenses have been developed, by means of different strategies of drug loading, leading to promising results. This review aims to report the recent advances in the development of therapeutic ophthalmic lenses for the treatment and/or prophylaxis of eye pathologies (i.e., glaucoma, cataract, corneal diseases, or posterior segment diseases) and it gives an overview of the future perspectives and challenges in the field.

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Laser-triggered intraocular implant to induce photodynamic therapy for posterior capsule opacification prevention

Cited by 23 publications

References 25 publications

Further Enhancement of Intraocular Open-Capsule Devices for Prevention of Posterior Capsule Opacification

Further Enhancement of Intraocular Open-Capsule Devices for Prevention of Posterior Capsule Opacification

Photothermal Ring Integrated Intraocular Lens for High‐Efficient Eye Disease Treatment

Therapeutic Ophthalmic Lenses: A Review

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