Laser vaporization of grade 3 vaginal intraepithelial neoplasia

Hoffman,; Ws, Roberts; Jp, LaPolla; Jv, Fiorica; Cavanagh, Denis

doi:10.1016/0020-7292(92)91035-m

Cited by 3 publications

(6 citation statements)

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“…We excluded patients with multifocal lesions in the vagina in the current study because multifocal lesions are associated with anogenital neoplastic syndrome in most patients, and they are more difficult to be cured than unifocal lesions due to the difficulty in laser vaporization [16]. In addition, we followed up all patients during a period of at least 10 months for determining disease recurrence, which is a longer duration than that of previous studies [4,7,16]. As a result, we obtained a recurrence rate of 26.5% after laser vaporization, which is similar to those of previous studies (0-42%) [4,7,[17][18][19].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, we followed up all patients during a period of at least 10 months for determining disease recurrence, which is a longer duration than that of previous studies [4,7,16]. As a result, we obtained a recurrence rate of 26.5% after laser vaporization, which is similar to those of previous studies (0-42%) [4,7,[17][18][19]. Unlike previous studies, risk factors for recurrence of VAIN in the vaginal vault after laser vaporization were age ( 48 years) and VAIN III in the vaginal vault before laser vaporization in the current study.…”

Section: Discussionmentioning

confidence: 99%

“…The other risk factors, VAIN III seems to be important for the prediction of recurrence in the vaginal vault after laser vaporization. Like the current study, some authors have cautioned physicians against the use of laser in the treatment of VAIN III lesions which occur in the vaginal vault after hysterectomy because of the possibility of misdiagnosing invasive cancer [4].…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, vaginal intraepithelial neoplasia (VAIN) may develop in the vaginal vault after hysterectomy although VAIN is 100 times less frequent than CIN [2]. Previous studies demonstrated that 83.3% of patients with VAIN have been reported to have at least one of the predisposing factors such as human papillomavirus (HPV) infection, radiation therapy and immunosuppression [2][3][4][5]. CIN or vulvar intraepithelial neoplasia (VIN) is found in 33.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Risk factors for recurrence of vaginal intraepithelial neoplasia in the vaginal vault after laser vaporization

Kim

Park

et al. 2009

Lasers Surg Med

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Risk factors for recurrence of vaginal intraepithelial neoplasia in the vaginal vault after laser vaporization

Kim

Park

et al. 2009

Lasers Surg Med

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“…Success rates of multifocal lesions treated with laser vaporisation ranges from 50% to 100% with a cure rate of approximately 70% (Krebs 1989;Hoffman et al 1991;Yalcin et al 2003). Topical application of 5-fluorouracil (5-FU) has also been investigated in different studies as a treatment option for multifocal lesions in the lower third of the vagina or recurrent lesions.…”

Section: Vagina Intraepithelial Neoplasiamentioning

confidence: 99%

Management of precancerous lesions prior to conception and during pregnancy: a narrative review of the literature

Jy¹,

Baştu²,

Gungor-Ugurlucan³

2012

European Journal of Cancer Care

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Special considerations aiming at preserving reproductive function have to be implemented when treating young patients with precancerous lesions of the lower genital tract. These high-grade lesions may progress into invasive cancer if left untreated. Currently, there are limited data on the impact of vulvar and vaginal precancerous lesions on fertility and its management during pregnancy. However, management and outcomes for cervical lesions have been extensively reported. The main approach for vulvar and vaginal lesions are maintaining anatomical function and cosmetics; whereas, treatment options for cervical precancerous lesions range from observation, cryotherapy or the more aggressive conisation. Gestational age is the most important factor in determining expectant management or surgical intervention. This narrative review draws attention to the relevant aspects of precancerous lesions of the lower genital tract, the potential effects and management prior to conception and during pregnancy.

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CO2 laser colposcopic guided surgery for the see and treat management of VHSIL: a preliminary experience

Bianchi

Auzzi²,

Turrini

et al. 2021

Lasers Med Sci

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The purpose of this study is to evaluate the efficiency of CO2 laser colposcopic guided surgery performed in an outpatient see and treat setting in the management of VHSIL. Women with a suspected diagnosis of VHSIL and no vulvoscopic suspicion of vSCC were enrolled. An electronic register of CO2 laser treatment was created where description of performing parameters (excision or ablation) was specified and personal history was recorded. Statistical analysis was performed by Fisher’s exact test. Relative risks (RR) of risk factor were calculated and expressed in odds. From September 2014 to September 2018, we enrolled a total of 63 patients who underwent CO2 laser procedure and had a minimum follow-up time of 2 years at Careggi University Hospital in Florence. Forty-eight (76.2%) patients underwent laser excision and 15 (23.8%) patients underwent ablative treatment without histological results. Undertreatment was performed in 3 cases (6.3%) with definitive histology of vSCC. Therapeutical appropriateness of CO2 laser excision was reached in 85.4% of the cases (41/48). No volunteer loss to follow-up was registered; thus, fidelity to treatment was assess at 100%. Recurrence rate within 2 years attested in 8/60 followed patients (13.3%). No personal factor was found to influence the VHSIL course. CO2 laser excision may represent an excellent therapeutic option to VHSIL because it provides adequate oncological purpose with good cosmetic and functional results and high patients’ loyalty to treatment. An expert team could allow to undergo patients with VHSIL suspicion to unique diagnostic and therapeutic procedure with significant benefits.

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Laser vaporization of grade 3 vaginal intraepithelial neoplasia

Cited by 3 publications

References 0 publications

Risk factors for recurrence of vaginal intraepithelial neoplasia in the vaginal vault after laser vaporization

Risk factors for recurrence of vaginal intraepithelial neoplasia in the vaginal vault after laser vaporization

Management of precancerous lesions prior to conception and during pregnancy: a narrative review of the literature

CO2 laser colposcopic guided surgery for the see and treat management of VHSIL: a preliminary experience

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