Furazolidone combination therapy appears to be effective. Additional studies with different antimicrobial combinations and duration of therapy are warranted.
Omega‐3 fatty acids were evaluated to determine how their anti‐inflammatory properties affect wound healing. Twelve Beagle dogs were divided into two groups of six. Group I was fed an n‐3 fatty acid enriched diet (n‐3 FAED) with an n‐6 to n‐3 fatty acid ratio of 0.3, and group II was fed a control diet (CD) with a ratio of 7.7. Open and sutured cutaneous wounds were created on the trunk of the dog, and evaluated by laser Doppler perfusion imaging, tensiometry, planimetry, histopathology, and eicosanoid content. At 5 days, the n‐3 FAED‐fed dogs had significantly less epithelialization of the open wounds (P = 0.0343) and significantly less oedema in sutured wounds (P = 0.015). There were also tendencies of less tissue perfusion (P = 0.086), lower PGE2 levels (P = 0.0756) and negative wound contraction in open wounds at 5 days. The n‐3 FAED used in this study did not appear to have any outstanding long‐term negative effect on wound healing.
Humans are unable to synthesize linoleic acid (LA) (18: 2ω‐6) and α‐linolenic acid (LNA) (18: 3ω‐3). Most formulas provide ample LA, yet infants are at risk for ω‐3 deficiency unless they are fed human milk. Neonates born at 30 weeks received human milk or were randomized to three formulas: formula A, based on corn oil, similar to old commercial formula; formula B, based on soy oil supplied LNA; or formula C, a product similar to B with added marine oil to provide docosahexaenoic acid (22:6 ω‐3). The fatty acids of plasma and red blood cells had marked diet‐induced differences. The rod photoreceptor tests demonstrated higher threshold and decreased sensitivity in the ω‐3‐deficient infants. Visual acuity also showed improved function of the brain cortex in the human milk and group C infants at follow‐up at 57 weeks. These results suggest that ω‐3 fatty acids are needed for optimal development of visual function.
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