Lasers in Dermatology

Alster, Tina S.; Lupton, Jason R.

doi:10.2165/00128071-200102050-00004

Cited by 50 publications

(7 citation statements)

References 129 publications

(126 reference statements)

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“…Both QS‐KTP and TXA showed statistically significant improvements in EI. This is possibly explained by concomitant absorption of 532 nm light by oxyhemoglobin within the superficial dermis [29], and the inhibition of vascular proliferation and basic fibroblast growth factor‐induced neovascularization by TXA [17].…”

Section: Discussionmentioning

confidence: 99%

Q‐Switched Nd:YAG (532 nm) Laser Versus Intra‐Dermal Tranexamic Acid for Treatment of Facial Ephelides: A Split Face, Randomized, Comparative Trial

2020

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Background and Objectives: To compare the efficacy and safety of intradermal injection of tranexamic acid (TXA) versus Q switched (QS) KTP (532 nm) in the treatment of facial ephelides. Study Design/Materials and Methods: A randomized comparative split-face study included a total of 30 female patients with bilateral facial ephelides. One cheek was treated by intra-dermal TXA injections and the other was treated by QS-KTP (532 nm). Patient assessment was performed by photography, pigmentation area, severity index and spectrophotometry at baseline, 1 week after treatment, and 2 months after treatment. Results: A significant difference was found between both sides regarding the percentage change of pigmentation area, severity score (PSI) and melanin index (MI) after treatment and during follow up, favoring laser (P = 0.001). PSI decreased after treatment by 66.5% and 15.4% (laser and TXA sides respectively), further decrease after followup was 69.4% with laser and 26.1% with TXA. MI improved by 3.7% after KTP laser to 7.7% after follow-up and by 2.4% after TXA injections to 6.5% after follow-up. Four patients developed post-inflammatory hyperpigmentation following QS-KTP. Conclusion: QS-KTP laser is superior to intradermal TXA injection in the treatment of facial ephelides. Lasers Surg. Med.

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Section: Discussionmentioning

confidence: 99%

Q‐Switched Nd:YAG (532 nm) Laser Versus Intra‐Dermal Tranexamic Acid for Treatment of Facial Ephelides: A Split Face, Randomized, Comparative Trial

2020

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“… 2 The first light amplification of stimulated emission of radiation was created in 1955 by Maiman. 3 The amplification system used a ruby crystal with red light beam and a wavelength of 694 nm. Many other means were developed from this, either solid (eg, neodymium-doped yttrium-aluminum-garnet) or gaseous (eg, CO 2 ).…”

Section: Lasers In Dermatologymentioning

confidence: 99%

“…Many other means were developed from this, either solid (eg, neodymium-doped yttrium-aluminum-garnet) or gaseous (eg, CO 2 ). 3 …”

Section: Lasers In Dermatologymentioning

confidence: 99%

Photoaging and the clinical utility of fractional laser

Borges¹,

Manela-Azulay²,

Cuzzi³

2016

CCID

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The description of atomic structure by Niels Bohr set the basis for the emergence of quantum physics. Based on these fundamentals, Einstein published in 1917 a paper on the amplification of energy by Stimulated Emission of Radiation as part of his quantum theories. In 1955, Townes and Gordon turned Einstein’s theories into practice, creating a coherent and amplified microwave device using ammonia gas in an optical medium. But it was at the beginning of the 1980s, that Anderson and Parrish published an article about the selective photothermolysis model which revolutionized clinical practice. The use of laser in photoaging began with CO2 (10,600 nm). In 1989, it was first used for resurfacing of a face with prominent photoaging. Ablative lasers have therefore had great popularity in the 1980s and 1990s, but prolonged postoperative time and significant risk of side effects have lowered the acceptance by patients. In 2004, the description of the fractionated radiation for the treatment of photoaging, by Mainstein, represented a great event. The stimulation of collagen occurred through fractional laser beams, which would reach the selected area while saving islands of sound skin. These islands accelerated the process of cicatrization of the treated tissue and shortened the postprocedure time. Furthermore, the fractionated radiation presented a smaller range of side effects, increasing the safety of the procedure. As mentioned earlier, as fractional lasers incise on the skin, they leave islands of healthy skin that accelerate recovery, while generating necrosis columns. Such necrosis columns remove damaged extracellular matrix material, allowing resettlement of fibroblasts. Such resettled fibroblasts, under the influence of a new tensile strength, restart to produce structures for extracellular matrix, such as collagen, elastin, and proteoglycans, in a more physiological way. Fractional lasers are considered by many dermatologists as the best choice in laser therapy for the treatment of photoaging.

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“…Laser-based tissue destruction is based on the characteristics of laser wavelength, chromophore targeting, energy density, and laser pulse duration such that when these parameters are optimized, appropriate energy is delivered for targeted laser resurfacing with minimal collateral tissue damage 3. In the 1980s, continuous wave CO 2 lasers became available for more effective esthetic resurfacing, but resulted in mixed outcomes that included many anticipated side effects following resurfacing treatment 4.…”

Section: Ablative Laser Resurfacing Backgroundmentioning

confidence: 99%

Skin resurfacing procedures: new and emerging options

Loesch

Somani

Kingsley

et al. 2014

CCID

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The demand for skin resurfacing and rejuvenating procedures has progressively increased in the last decade and has sparked several advances within the skin resurfacing field that promote faster healing while minimizing downtime and side effects for patients. Several technological and procedural skin resurfacing developments are being integrated into clinical practices today allowing clinicians to treat a broader range of patients’ skin types and pathologies than in years past, with noteworthy outcomes. This article will discuss some emerging and developing resurfacing therapies and treatments that are present today and soon to be available.

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Lasers in Dermatology

Cited by 50 publications

References 129 publications

Q‐Switched Nd:YAG (532 nm) Laser Versus Intra‐Dermal Tranexamic Acid for Treatment of Facial Ephelides: A Split Face, Randomized, Comparative Trial

Q‐Switched Nd:YAG (532 nm) Laser Versus Intra‐Dermal Tranexamic Acid for Treatment of Facial Ephelides: A Split Face, Randomized, Comparative Trial

Photoaging and the clinical utility of fractional laser

Skin resurfacing procedures: new and emerging options

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