Quantum wire lasers are generally fabricated through complex overgrowth processes with molecular beam epitaxy. The material systems of such overgrown quantum wires have been limited to Al-Ga-As-P, which leads to emission largely in the visible region. We describe a simple, one-step chemical vapor deposition process for making quantum wire lasers based on the Al-Ga-N system. A novel quantum-wire-in-opticalfiber (Qwof) nanostructure was obtained as a result of spontaneous Al-Ga-N phase separation at the nanometer scale in one dimension. The simultaneous excitonic and photonic confinement within these coaxial Qwof nanostructures leads to the first GaN-based quantum wire UV lasers with a relatively low threshold.Quantum confinement of charge carriers in more than one dimension in quantum wires and quantum dots has been predicted to yield improved performance of semiconductor lasers, relative to conventional quantum well devices. 1,2 The carrier confinement is expected to lead to reduced threshold currents and narrower spectral line widths. The potential advantages of the quantum wire lasers could make them ideal for a variety of applications that require coherent light sources with low power consumption and high-speed digital modulation capability. A major challenge, however, has been the development of the fabrication technology for preparing quantum wire heterostructures that are compatible with laser applications. Almost all quantum wire lasers reported thus far have been made through molecular beam epitaxy, microfabrication, and lithographical techniques on the GaAs/InP system for visible light emission. 1,3,4 Significant technical hurdles exist for the direct fabrication of GaN-based quantum wire lasers, despite their obvious potential in short-wavelength photonic devices and hightemperature/high-power optoelectronics. 5-8 Herein, we report the first realization of self-organized, monolithically singlecrystalline GaN/Al x Ga 1-x N (x ) 0.75) core-sheath onedimensional (1D) nanostructures. Quantum wires of GaN (refractive index of 2.54) with diameters as small as 5 nm are cladded by Al 0.75 Ga 0.25 N (refractive index of 2.25) sheaths with uniform thicknesses in the range of 50-100 nm, forming a novel quantum-wire-in-optical-fiber (Qwof) structure. As a manifestation of the quantum confinement, a blue shift of the photoluminescence (PL) has been observed. Moreover, the simultaneous excitonic and photonic confinement within these coaxial Qwof nanostructures leads to the first GaN-based quantum wire UV lasers with relatively low thresholds.Recently, UV lasing has been demonstrated by our groups for the ZnO and GaN nanowire systems. [9][10][11] In these earlier studies, the entire faceted nanowire (generally with a diameter of >100 nm) serves both as a gain medium and as a FabryPerot optical cavity. This nanowire nanolaser configuration places a lower limit on the lasing nanowire diameter, approximately λ/2n (where n is the refractive index), below which the nanowire is no longer capable of sustaining even a leaky ...