Lasiodiplodin Analogues from the Endophytic Fungus &lt;i&gt;Sarocladium kiliense&lt;/i&gt;

Yuan, Wei; Jiang, Nan; Dong, Cai Hong; Wei, Zhi Wen; Wu, Han Kui; Chen, Cai Fa; Zhao, Yan; Zhou, Shengliang; Zhang, Mei Mei; Zheng, Wei Fa

doi:10.1248/cpb.c12-00898

Cited by 10 publications

(3 citation statements)

References 11 publications

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“…In the present study, seven of 18 genera of endophyte have previously been documented as endophytes, including C. globosum (Borges et al, 2011), A. fumigatus (Kusari et al, 2009), T. asperellum (Hanada et al, 2008), S. kiliense (Yuan et al, 2013), Alternaria sp. (Li et al, 2010),…”

Section: Discussionsupporting

confidence: 56%

Diversity and importance of culturable endophytic fungi of tobacco (Nicotinana tabacum) cultivated in southwestern China

Wang

Sun

Ya-li

et al. 2022

Journal of Phytopathology

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Tobacco (Nicotiana tabacum) is one of the most important economic crops in China; however, black shank caused by Phytophthora parasitica is major threat to its cultivation. So far, little is known regarding potential antagonistic effects of endophytes on plant pathogens. A total of 109 culturable endophytic fungal strains were recovered from various tissues of six tobacco cultivars that are commonly cultivated in southwestern China. Morphological and molecular identification showed that these isolates belonged to 18 different genera, including Aspergillus, Chaetomium, Gibellulopsis and Penicillium as predominant genera, which were frequently observed in stem, leaf and root tissues. Among them, only 17 endophytic fungal strains exerted antagonistic effects on P. parasitica in the dual-culture test, and the highest inhibition rate of 73% was produced by a Penicillium janthinellum strain isolated from stem tissue of a cultivar HD. Nevertheless, a field trial revealed that Shannon-Wiener indices were negatively correlated with the disease index and with the incidence of tobacco blank shank in cultivars K326, YUN85, D101 and GUI1, which was further supported by the evaluation of endophytic community similarity. Our results contribute to the understanding of functions and diversity of endophytic fungi, and culturable endophytic fungal strains may be considered potential libraries for screening novel bioactive and effective metabolites to control P. parasitica in crops which requires further research.

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Section: Discussionsupporting

confidence: 56%

Diversity and importance of culturable endophytic fungi of tobacco (Nicotinana tabacum) cultivated in southwestern China

Wang

Sun

Ya-li

et al. 2022

Journal of Phytopathology

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“…isolated from Excoecaria agallocha were identified several compounds belonging to the lasiodiplodins series [ 18 , 47 ]. Although lasiodiplodins production has been reported in other fungal species (i.e., Sarocladium kiliense , Syncephalastrum racemosum ) [ 84 , 85 ] and in many plants (i.e., Ampelopsis japonica, Euphorbia splendens, Macroptilium lathyroides ) [ 83 , 86 ], these compounds are frequently identified in cultures of Lasiodiplodia theobromae ( Table 2 ). Furthermore, several authors assumed that lasiodiplodins may not be plant metabolites but may be produced by symbiotic fungi [ 87 ].…”

Section: Secondary Metabolitesmentioning

confidence: 99%

Secondary Metabolites of Lasiodiplodia theobromae: Distribution, Chemical Diversity, Bioactivity, and Implications of Their Occurrence

Salvatore

Alves

Andolfi

2020

Toxins

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Lasiodiplodia theobromae is a plant pathogenic fungus from the family Botryosphaeriaceae that is commonly found in tropical and subtropical regions. It has been associated with many hosts, causing diverse diseases and being responsible for serious damages on economically important crops. A diverse array of bioactive low molecular weight compounds has been described as being produced by L. theobromae cultures. In this review, the existing literature on secondary metabolites of L. theobromae, their bioactivity, and the implications of their occurrence are compiled. Moreover, the effects of abiotic factors (e.g., temperature, nutrient availability) on secondary metabolites production are highlighted, and possible avenues for future research are presented. Currently, a total of 134 chemically defined compounds belonging to the classes of secondary metabolites and fatty acids have been reported from over 30 L. theobromae isolates. Compounds reported include cyclohexenes and cyclohexenones, indoles, jasmonates, lactones, melleins, phenols, and others. Most of the existing bioactivity studies of L. theobromae metabolites have assessed their potential phytotoxic, cytotoxic, and antimicrobial activities. In fact, its host adaptability and its ability to cause diseases in plants as well as in humans may be related to the capacity to produce bioactive compounds directly involved in host–fungus interactions.

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“…Correspondingly, the stereochemistry of C-3 and C-5 of compound 3 was determined as 3 S , 5 S . For the other analogue ( 3S ),( 6R )-6-hydroxylasiodiplodin [6], the carbon chemical shift of 6R at δ C 70.5 in CDCl 3 /CD 3 OD solvent was distinctly different from the carbon chemical shift at C-6 position of compound 3 at δ C 76.3 in CD 3 OD solvent. Furthermore, the NOESY spectrum of compound 3 displayed a NOE correlation between H-5 and H-6, therefore, the absolute configuration of (5 S ,6 S )-dihydroxylasiodiplodin was proposed to be (3 S ,5 S ,6 S ).…”

Section: Resultsmentioning

confidence: 99%

Two Additional New Compounds from the Marine-Derived Fungus Pseudallescheria ellipsoidea F42-3

Wang

Liu

et al. 2016

Molecules

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Two additional new compounds, pseudellone D (1) and (5S,6S)-dihydroxylasiodiplodin (3), along with the two known compounds lasiodipline F (2), (5S)-hydroxylasiodiplodin (4) were isolated from the marine-derived fungus Pseudallescheria ellipsoidea F42-3 associated with the soft coral Lobophytum crassum. Their structures, including absolute configurations, were elucidated on the basis of the corresponding spectroscopic data and electronic circular dichroism (ECD) spectra.

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Lasiodiplodin Analogues from the Endophytic Fungus <i>Sarocladium kiliense</i>

Cited by 10 publications

References 11 publications

Diversity and importance of culturable endophytic fungi of tobacco (Nicotinana tabacum) cultivated in southwestern China

Diversity and importance of culturable endophytic fungi of tobacco (Nicotinana tabacum) cultivated in southwestern China

Secondary Metabolites of Lasiodiplodia theobromae: Distribution, Chemical Diversity, Bioactivity, and Implications of Their Occurrence

Two Additional New Compounds from the Marine-Derived Fungus Pseudallescheria ellipsoidea F42-3

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