Lassa virus glycoproteins: antigenic and immunogenic properties of synthetic peptides to GP1

Krasko, Anatoli; Moshnikova, Anna; Kozhich, Alexander; Tchikin, Leonid D.; Иванов, В. Т.; Vladyko, A. S.; Lukashevich, Igor S.

doi:10.1007/bf01310630

Cited by 6 publications

(1 citation statement)

References 13 publications

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“…Monoclonal antibodies with neutralizing activities are produced exclusively against LCMV GP1 glycoprotein [170][171][172]. Anti-LASV polyclonal antibodies bound effectively to the most surface-exposed regions of LASV GP1 (predicted Bcell epitopes) corresponding to amino acid residues 119-133 and 164-176 [173]. The LASV GP1 is a heavily glycosylated glycoprotein having seven potential N-glycosylation sites at positions, 81, 91, 101, 111, 121, 169, and 226 [168].…”

Section: The Gp1 and Cell Receptor Bindingmentioning

confidence: 99%

Lassa Virus Genome

Igor¹,

Sica²

2006

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Lassa virus (LASV), the most dangerous human pathogen among the Arenaviridae, belongs to a complex of genetically related virus strains responsible for the deaths of thousands of people in West Africa each year. The virus has a bi-segmented (L and S) single-stranded RNA genome. Each segment contains two genes in ambisense orientation. The L RNA encodes a large protein, L, or RdRp and a small zinc-binding, Z protein. The S RNA encodes the major structural proteins, nucleoprotein (NP) and glycoprotein precursor (GPC), cleaved into signal peptide, GP1, and GP2 glycoproteins. Genetic diversity among LASV strains is the highest within the family Arenaviridae and NP and RdRp genes are the most variable among LASV genes. The LASV genetic diversity is a great challenge for vaccine development.In addition to LASV and the prototype lymphocytic choriomeningitis virus (LCMV), the Old World group of arenaviruses includes three other related viruses, Mopeia (MOPV), Mobala (MOBV), and Ippy (IPPYV). These viruses as well as a MOP/LAS reassortant carrying the L RNA segment from MOPV and S RNA segment from LASV are non-pathogenic for experimental animals and are able to induce protective immunity against LASV. Lassa Fever pathogenesis is a sum of the effects induced by viral replication and immune response. The goal of this review is to cover recent publications on viral and host genes that control LASV virulence. The full-length genome sequence of LASV isolates and LASV-related nonpathogenic arenaviruses will provide a useful genetic tool to map LASV genes involved in virulence and to gain insight into phylogeny and evolution of the Old World arenaviruses.

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Section: The Gp1 and Cell Receptor Bindingmentioning

confidence: 99%

Lassa Virus Genome

Igor¹,

Sica²

2006

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Synthetic Peptides as Diagnostic Tools in Virology

Leinikki

Lehtinen²,

Hyöty³

et al. 1993

Advances in Virus Research

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Lassa Virus

Günther

Lenz

2004

Critical Reviews in Clinical Laboratory Sciences

186

120

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Lassa virus is a RNA virus belonging to the family of Arenaviridae. It was discovered as the causative agent of a hemorrhagic fever--Lassa fever--about 30 years ago. Lassa fever is endemic in West Africa and is estimated to affect some 100,000 people annually. Great progress in the understanding of the life cycle of arenaviruses, including Lassa virus, has been made in recent years. New insights have been gained in the pathogenesis and molecular epidemiology of Lassa fever, and state-of the-art technologies for diagnosing this life-threatening disease have been developed. The intention of this review is to summarize in particular the recent literature on Lassa virus and Lassa fever. Several aspects ranging from basic research up to clinical practice and laboratory diagnosis are discussed and linked together.

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Lassa virus glycoproteins: antigenic and immunogenic properties of synthetic peptides to GP1

Cited by 6 publications

References 13 publications

Lassa Virus Genome

Lassa Virus Genome

Synthetic Peptides as Diagnostic Tools in Virology

Lassa Virus

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