Latanoprost-Eluting Contact Lenses in Glaucomatous Monkeys

Ciolino, Joseph B.; Ross, Amy E.; Tulsan, Rehka; Watts, Amy; Wang, Rongfang; Zurakowski, David; Serle, Janet B.; Kohane, Daniel S.

doi:10.1016/j.ophtha.2016.06.038

Cited by 75 publications

(45 citation statements)

References 24 publications

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“…Given the cornea's superficial and easily accessible location, we could also consider the use of contact lenses as a drug delivery system for LBP. The use of latanoprost-eluting contact lenses has already shown promising results in combating poor long-term drug compliance in glaucomatous optic neuropathy [41]. Furthermore, scleral contact lens systems have been used as a method to effectively deliver bevacizumab to the ocular surface as a method to treat sight-threatening corneal neovascularization [42].…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review of Potential Therapeutic Use of Lycium Barbarum Polysaccharides in Disease

Kwok

et al. 2019

BioMed Research International

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Objective. To evaluate the effect of Lycium barbarum polysaccharides in the treatment and/or prevention of diseases of different etiologies and systems. Methods. We performed an Entrez PubMed literature search using keywords “lycium”, “barbarum”, “polysaccharides”, “anti-fibrotic”, “anti-apoptotic”, “anti-oxidizing”, “anti-aging”, “neuroprotection”, “metabolism”, “diabetes”, “hyperlipidemia”, “neuroprotection”, and “immunomodulation” on the 14th of August 2018, resulting in 207 papers, of which 20 were chosen after filtering for ‘English language’ and ‘published within 10 years’ as well as curation for relevance by the authors. Results. The 20 selected papers included 2 randomized control trials (1 double-blinded RCT and 1 double-blinded placebo-controlled RCT), 11 in vivo studies, 5 in vitro studies, 1 study with both in vivo and in vitro results, and 1 chemical study. There is good evidence from existing studies on the antifibrotic, antioxidizing, neuroprotective, anticancer, and anti-inflammatory effects of Lycium barbarum polysaccharides. However, there is a need for further studies in the form of large-scale clinical trials to support its use in humans. There is also significant potential for LBP as a safe and effective topical treatment in ocular surface diseases, owing to promising in vitro results and a lack of demonstrated toxic effects to corneal epithelial cells. Conclusion. Results from existing studies suggest that LBP is a promising therapeutic agent, particularly in the management of liver disease, hyperlipidemia, and diabetes. One major limitation of current research is a lack of standardization and quality control for the LBP used. The availability of research-grade LBP will inevitably promote future research in this field worldwide.

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Section: Discussionmentioning

confidence: 99%

A Systematic Review of Potential Therapeutic Use of Lycium Barbarum Polysaccharides in Disease

Kwok

et al. 2019

BioMed Research International

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“…Ciolino et al tested the effect of latanoprost-eluting contact lenses in a preclinical study with a 3-arm cross-over design. [19] Glaucoma was induced in 4 eyes of female cynomolgus monkeys by repeated argon laser trabeculoplasty. Each monkey wore a continuous-wear low-dose (97 µg) latanoprost-eluting contact lens for 1 week, followed by a washout period of 3 weeks and 5 days of latanoprost topical drops.…”

Section: Contact Lensesmentioning

confidence: 99%

Sustained drug delivery platforms – A new era for glaucoma treatment

Shouchane-Blum¹,

Geffen²,

Zahavi³

2019

cleverjournal

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Glaucoma is a leading cause of blindness worldwide. Treatment typically consists of the chronic administration of topical eye drops. However, fluctuations in intraocular pressure, local and systemic side effects, and low patient compliance have prompted the development of various sustained drug delivery platforms, both extraocular and intraocular, over the last decade. Some are currently undergoing advanced clinical trials. Extraocular platforms include wearable ocular surface devices (such as ocular insert rings, topical ocular drug delivery devices, gel-forming eye drops, collagen shields, and contact lenses), punctal plugs (such as the OTX-TP and Latanoprost punctal plug delivery system), and subconjunctival injections (such as the EyeD VS-101, POLAT-001, GB-6249-103, IBI-60089, and dorzolamide-loaded polymer microparticles). Intraocular platforms include mainly intracameral implants (such as the Bimatoprost SR, ENV515 Travoprost XR, iDose, OTX-TIC, PA5108, and DE-117-loaded PLC), although other devices are drawing attention as potential treatment alternatives (such as intravitreal nanosponges and supraciliary implants). The purpose of this review is to describe these emerging sustained drug delivery systems for the treatment of glaucoma and ocular hypertension.

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“…Remarkable hardware-based advances in health care include medicinal contact lenses [Ciolino et al, 2016], tooth sensors [Tseng et al, 2018], and ingestible sensors [Kalantar-Zadeh et al, 2018]. Other astonishing advances include pharmaceutical-related mechanisms such as synthesized antibiotics [Parmar et al, 2016] and cancer vaccines [Sagiv-Barfi et al, 2018].…”

Section: Predictive Modeling In Health Carementioning

confidence: 99%

Beyond Traditional Covariates in Medical Informatics

Kartoun¹

2019

Preprint

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Deep behavioral covariates (DBCs) introduced in this perspective form a new class of covariates that have the potential to enhance the performance of predictive models and improve analytics in clinical decision support applications. DBCs can measure how engaged a patient tends to be and how he or she tends to respond to events, and they may be highly predictive of the patient’s outcomes for a planned treatment. DBCs may potentially serve as a standard to measure patient engagement and activation and may form highly efficient mechanisms for improving patient outcomes.

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Latanoprost-Eluting Contact Lenses in Glaucomatous Monkeys

Cited by 75 publications

References 24 publications

A Systematic Review of Potential Therapeutic Use of Lycium Barbarum Polysaccharides in Disease

A Systematic Review of Potential Therapeutic Use of Lycium Barbarum Polysaccharides in Disease

Sustained drug delivery platforms – A new era for glaucoma treatment

Beyond Traditional Covariates in Medical Informatics

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