Late complications of therapy in 213 children with localized, nonorbital soft-tissue sarcoma of the head and neck: A descriptive report from the Intergroup Rhabdomyosarcoma Studies (IRS)-II and - III

Raney, R. Beverly; Asmar, Lina; Vassilopoulou‐Sellin, Rena; Klein, Mary Jean; Donaldson, Sarah S.; Green, Jennifer; Heyn, Ruth; Wharam, Moody D.; Glicksman, Arvin S.; Gehan, Edmund A.; Anderson, James R.; Maurer, Harold M.

doi:10.1002/(sici)1096-911x(199910)33:4<362::aid-mpo4>3.0.co;2-i

Cited by 167 publications

(110 citation statements)

References 28 publications

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“…Therefore radiotherapy is often necessary to achieve local control. Radiotherapy, however, is known to cause damage to tissues and may cause growth abnormalities and impaired function [5][6][7][8][9][10]. Since RMS primarily occurs in young children, adverse events (AEs) may be more severe.…”

Section: Introductionmentioning

confidence: 99%

Adverse events of local treatment in long-term head and neck rhabdomyosarcoma survivors after external beam radiotherapy or AMORE treatment

Schoot

Slater

Ronckers

et al. 2015

European Journal of Cancer

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Section: Introductionmentioning

confidence: 99%

Adverse events of local treatment in long-term head and neck rhabdomyosarcoma survivors after external beam radiotherapy or AMORE treatment

Schoot

Slater

Ronckers

et al. 2015

European Journal of Cancer

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“…13,14 Surgical treatment with adjuvant radiotherapy is currently the treatment of choice for laryngeal disease. 2 However the use of adjuvant combination Chemotherapy with radiotherapy is gaining ground and reducing the need for mutilating surgery in head and neck rhabdomyosarcoma 15,16 ; however it is not clear if this modality of treatment has any significant effect on outcome in adult laryngeal disease considering that only few cases has been reported. Improvement in outcome has been shown to occur with multimodality treatment regimens for head and neck rhabdomyosarcoma.…”

Section: Discussionmentioning

confidence: 99%

Adult laryngeal rhabdomyosarcoma: Report of a case and literature review

et al. 2007

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Rhabdomyosarcoma is relatively seen in the pediatric age group with the head and neck region as the commonest site. To the best of our knowledge, few cases of laryngeal involvement in adult have been described in the literature. Biologically, rhabdomyosarcoma is different from squamous cell carcinoma, which is the commonest tumor of the larynx. A previously healthy non-smoker 77-year-old lady presented to the ENT outpatient with a six weeks history of intermittent alteration of voice quality. She had no history of sore throat, or any symptoms suggesting laryngo-pharyngeal reflux. Examination showed asymmetry of the left arytenoid cartilage and aryepiglottic fold. She subsequently had a direct laryngoscopy and biopsy. Histology and immunohistochemistry examination suggested the diagnosis of mesenchymal neoplasm. Following discussion at MDT she subsequently had a total laryngectomy. Histology confirmed a completely excised laryngeal rhabdomyosarcoma. Rhabdomyosarcoma of larynx in adult is a rare disease. Surgical treatment with or without adjuvant radiotherapy is currently the treatment of choice for this disease. Key words: Rhabdomyosarcoma, larynx cancer RésuméLe Rhabdomyosarcome est relativement connu dans le groupe d'âge pédiatrique et les régions les plus touchées sont la tête et le cou. A notre connaissance, peu de cas de l'implication du larynx chez des adultes ont été cités dans la littérature. Biologiquement, rhabdomyosarcome est différent de la cellule squameuse carcinome, qui est la tumeur de larynx la plus ordinaire. Une femme non-fumeuse, âgée de 77 ans d'une très bonne santé au départ, s'est présentée à l'ORL ambulatoire avec une période de six semaines histoires de l'altération répétée de la qualité de la voix. Elle n'avait pas d'antécédente de maux de gorge ou aucun symptômes suggestifs le reflux laryngo-pharyngien. L'examen a montré l'asymétrie de la gauche aryténoïde cartilage aryepiglottique pli. Elle a par la suite eu une laryngoscopie directe et la biopsie. L'examen histologique et immunohistochimie a suggéré le diagnostique des tumeurs mesenchymteuses, néoplasme. A la suite d'une discussion au MDT elle a ensuite eu une laryngectomie totale. L'histologie a confirmé une excisée larynx chez des adultes qui est une maladie rare. Le traitement chirurgical avec ou sans radiothérapie adjuvante est actuellement le traitement du choix pour cette maladie.

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“…Rhabdomyosarcoma is considered a systemic disease, managed with multimodality therapies including surgery, chemotherapy and radiation, 40 frequently associated with adverse late sequela of treatment. 41 There is an overall poor prognosis of sinonasal tract alveolar rhabdomyosarcoma (5-year survival 30-40%), 29,35,[41][42][43][44] with patients frequently showing regional and/or distant metastases, although young patients (5-year survival 62.5%) tend to have a better prognosis. 28,32,43 Sinonasal Undifferentiated Carcinoma (SNUC) SNUC is a rare tumor, lacking glandular or squamous features, and is not otherwise classifiable.…”

Section: Mesenchymal Chondrosarcomamentioning

confidence: 99%

Small round blue cell tumors of the sinonasal tract: a differential diagnosis approach

Thompson

2017

Modern Pathology

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One of the most challenging diagnostic categories within tumors of the sinonasal tract is the small round blue cell tumors. Biopsies are usually small and limited, resulting in considerable diagnostic difficulty for practicing surgical pathologists. These tumors share several overlapping histologic and immunophenotypic findings while also showing considerable variation within and between cases. Specific tumor site of origin, imaging findings, and clinical findings must be combined with the histology and pertinent ancillary studies if the correct diagnosis is to be reached. Discrimination between neoplasms is critical as there are significant differences in therapy and overall outcome. It is important to have a well developed differential diagnosis for this category of tumors, where each of the diagnoses is considered, evaluated, and either confirmed or excluded from further consideration. In an undifferentiated tumor, showing a small round blue cell morphology, using the mnemonic 'MR SLEEP' helps to highlight tumors to consider: melanoma, mesenchymal chondrosarcoma, rhabdomyosarcoma, sinonasal undifferentiated carcinoma, squamous cell carcinoma (including NUT carcinoma), small cell osteosarcoma, lymphoma, esthesioneuroblastoma (olfactory neuroblastoma), Ewing sarcoma/primitive neuroectodermal tumor, pituitary adenoma, and plasmacytoma. A panel of pertinent immunohistochemistry studies, histochemistries and/or molecular tests should aid in reaching a diagnosis, especially when taking the pattern and intensity of reactions into consideration.

show abstract

Late complications of therapy in 213 children with localized, nonorbital soft-tissue sarcoma of the head and neck: A descriptive report from the Intergroup Rhabdomyosarcoma Studies (IRS)-II and - III

Cited by 167 publications

References 28 publications

Adverse events of local treatment in long-term head and neck rhabdomyosarcoma survivors after external beam radiotherapy or AMORE treatment

Adverse events of local treatment in long-term head and neck rhabdomyosarcoma survivors after external beam radiotherapy or AMORE treatment

Adult laryngeal rhabdomyosarcoma: Report of a case and literature review

Small round blue cell tumors of the sinonasal tract: a differential diagnosis approach

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