Late differences in outcomes of patients with stable angina and an isolated lesion in the proximal left anterior descending artery treated with new-generation drug-eluting stents

Toutouzas, Konstantinos; Patsa, Chrysoula; Matsoukis, Ioannis; Drakopoulou, Maria; Tsiamis, Eleftherios; Latsios, George; Synetos, Αndreas; Komatanou, Evmorfia; Spanos, Anastasios; Petridou, Eleni; Tousoulis, Dimitris

doi:10.1016/j.ijcard.2015.01.044

Cited by 4 publications

(5 citation statements)

References 24 publications

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“…We conducted a cross-sectional survey between October 2017 and January 2018, with 342 consecutive outpatients with stable angina from the outpatient Department of Cardiology at the Second Affiliated Hospital of Army Medical University, Chongqing, China. According to a previous definition [11, 12], patients with chronic stable angina and/or ischemia, as demonstrated via stress tests, exhibited stenosis of any diameter greater than 70% in at least one epicardial vessel. The exclusion criteria included lesions in the left main coronary artery; multivessel disease; acute coronary syndrome; and previous myocardial infarction, percutaneous coronary intervention, or coronary artery bypass grafting.…”

Section: Methodsmentioning

confidence: 99%

Correlation between exercise, personal income level and health-related quality of life in patients with newly diagnosed stable angina

2019

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BackgroundStable angina is one of the most common clinical types of coronary artery disease (CAD) and associated with poor health-related quality of life (HRQL). However, few studies have evaluated the risk factors associated with HRQL in patients with newly diagnosed stable angina.MethodsA cross-sectional survey was conducted with 342 consecutive outpatients with newly diagnosed stable angina from October 2017 to January 2018 at the Second Affiliated Hospital of Army Medical University, Chongqing, China. Eight dimensions of HRQL were evaluated via the 36-item Short-Form Health Survey, including physical functioning, role limitation due to physical problems, bodily pain, general health, vitality, social functioning, role limitation due to emotional problems, and mental health. Physical and mental component summaries were calculated. Multiple stepwise regression was performed to determine the factors associated with HRQL.ResultsPatients who were older, were females, did not exercise, had lower educational levels, had lower monthly incomes, had smoking/drinking habits, and had diabetes, hypertension, or hyperlipemia showed lower physical HRQL scores, while those who were older with lower educational levels and lower monthly incomes showed lower mental HRQL scores. The results of the multiple stepwise regression analyses showed that physical and mental HRQL were positively correlated with exercise and monthly income and negatively associated with age. Patients with monthly income ≥5000 Yuan showed higher HRQL scores than those with monthly income < 5000 Yuan. Sleep quality and drinking were negatively associated with physical, but not mental HRQL.ConclusionsOur findings indicated that exercise and personal income level, both modifiable factors, were positively associated with physical and mental HRQL. These findings could have implications for clinical suggestions and strategies to improve HRQL in patients with stable angina.

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Section: Methodsmentioning

confidence: 99%

Correlation between exercise, personal income level and health-related quality of life in patients with newly diagnosed stable angina

2019

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“…Endeavor-Sprint-ZES (29.5%) were included along with the EES in the DES-PCI group. Previous nonrandomized trials have shown that EES had better results, especially for target lesion revascularization, than the Endeavor-Sprint ZES [23][24][25][26][27] ; however, a subanalysis com-…”

Section: Discussionmentioning

confidence: 93%

“…Endeavor‐Sprint‐ZES (29.5%) were included along with the EES in the DES‐PCI group. Previous nonrandomized trials have shown that EES had better results, especially for target lesion revascularization, than the Endeavor‐Sprint ZES 23‐27 ; however, a subanalysis comparing EES‐PCI with CABG was not conducted in the current study due to potentially inadequate power because of the limited sample size. Although we adjusted for several possible or known factors that may affect our results, other factors, such as, medication at discharge might have affected our results.…”

Section: Discussionmentioning

confidence: 98%

Long‐term clinical outcomes of coronary artery bypass graft surgery compared to those of percutaneous coronary intervention with second generation drug eluting stents in patients with stable angina and an isolated lesion in the proximal left anterior descending artery

Matsoukis

Καρανάσος

Patsa

et al. 2020

Cathet Cardio Intervent

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Objectives: We compared the long-term outcomes of percutaneous coronary intervention with second-generation drug-eluting stents (PCI-DES) and coronary artery bypass graft surgery (CABG) with the left internal mammary artery in stable angina patients with isolated single-vessel proximal left anterior descending artery (pLAD) disease.Background: Long-term outcomes of second-generation PCI-DES and CABG in isolated pLAD lesions have not been extensively studied.Methods: We included 631 PCI-DES patients and 379 CABG patients. Unadjusted and adjusted hazard ratios (HRs) were derived for major adverse cardiac events (MACEs), their components (cardiac death, nonfatal myocardial infarction [MI] not attributed to a non-target vessel, target-lesion revascularization), and patient-related outcome (PRO, composed of all-cause mortality, any MI, any revascularization).Results: In the unadjusted and adjusted analyses, no significant difference was observed between the two groups at follow-up (mean:4.6 ± 2.5 years) for MACEs

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“…The use of new-generation of DES have shown much less rate of restenosis, giving opportunities for cure even in case of high-risk lesions such as ostial lesions 32 . Since there are still difference for each new generation of DES in terms of clinical outcomes 33 , there might be further chances to develop a new candidate drug for DES. Many drugs such as paclitaxel, sirolimus, and zotarolimus could be toxic to human body if adequate concentration of each oral drug for anti-proliferative effect should be reached.…”

Section: Discussionmentioning

confidence: 99%

Sildenafil Reduces Neointimal Hyperplasia after Angioplasty and Inhibits Platelet Aggregation via Activation of cGMP-dependent Protein Kinase

Yang

Jin

Jang

et al. 2019

Sci Rep

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Sildenafil is known to reduce cardiac hypertrophy through cGMP-dependent protein kinase (cGK) activation. Studies have demonstrated that cGK has a central switching role in modulating vascular smooth muscle cell (VSMC) phenotype in response to vascular injury. Here, we aimed to examine the effects of cGK activation by sildenafil on neointimal formation and platelet aggregation. After vascular injury, neointimal hyperplasia in rat carotid arteries was significantly reduced in the sildenafil-treated group. This effect of sildenafil was accompanied by the reduction of viability and migration of VSMCs. Further experiments showed that the increased cGK activity by sildenafil inhibited platelet-derived growth factor-induced phenotype change of VSMCs from a contractile form to a synthetic one. Conversely, the use of cGK inhibitor or gene transfer of dominant-negative cGK reversed the effects of sildenafil, increasing viability of VSMCs and neointimal formation. Interestingly, sildenafil significantly inhibited platelet aggregation induced by ADP or thrombin. This effect was reversed by cGK inhibitor, suggesting that sildenafil inhibits platelet aggregation via cGK pathway. This study demonstrated that sildenafil inhibited neointimal formation and platelet aggregation via cGK pathway. These results suggest that sildenafil could be a promising candidate for drug-eluting stents for the prevention of both restenosis and stent thrombosis.

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Late differences in outcomes of patients with stable angina and an isolated lesion in the proximal left anterior descending artery treated with new-generation drug-eluting stents

Cited by 4 publications

References 24 publications

Correlation between exercise, personal income level and health-related quality of life in patients with newly diagnosed stable angina

Correlation between exercise, personal income level and health-related quality of life in patients with newly diagnosed stable angina

Long‐term clinical outcomes of coronary artery bypass graft surgery compared to those of percutaneous coronary intervention with second generation drug eluting stents in patients with stable angina and an isolated lesion in the proximal left anterior descending artery

Sildenafil Reduces Neointimal Hyperplasia after Angioplasty and Inhibits Platelet Aggregation via Activation of cGMP-dependent Protein Kinase

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