Late effects of adriamycin single dose on fetal rat kidney—ultrastructural assessment

Pedrycz, Agnieszka; Wieczorski, Marcin; Czerny, K

doi:10.1016/j.etap.2004.12.050

Cited by 6 publications

(4 citation statements)

References 14 publications

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“…The subcellular structure of one viable SCCVII cell is visible. Figure 4d shows a TEM micro- To be more precise, the particle aggregates agglomerated and accumulated inside the membrane-bound space that was recognized as destroyed mitochondria 30 . The mitochondria have a swollen morphology with a bright matrix and completely destroyed cristae.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Mn3O4 nanoparticles and their application to cancer cells

Gotić

Ivanković

Musić

et al. 2009

Collect. Czech. Chem. Commun.

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The Mn3O4 nanoparticles were synthesized by optimizing the precipitation system MnCl2/H2O2/NH4OH. The material thus obtained was microstructurally characterized using X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM). The Mn3O4 nanoparticles were applied to fibroblast and cancer cells. In the concentration range 25–100 μg/ml the particles showed low cytotoxic effects on L929 fibroblast cells, medium cytotoxic effects on FsaR fibrosarcoma cells and high cytotoxic effects on SCCVII carcinoma cells. N-Acetyl-L-cysteine (NAC) increased cytotoxicity of Mn3O4 nanoparticles, which suggested that reactive oxygen species (ROS) were not responsible for their selective cytotoxic effect. It was shown that the Mn3O4 nanoparticles entered the cancer cells and aggregated inside the membrane-bound spaces that were recognized as destroyed mitochondria.

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Section: Resultsmentioning

confidence: 99%

Synthesis of Mn3O4 nanoparticles and their application to cancer cells

Gotić

Ivanković

Musić

et al. 2009

Collect. Czech. Chem. Commun.

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“…Motif 1 is present in every MDH sequence because it contains an active site that is an indispensable component of MDH sequences and plays a catalytic role when the substrate binds to MDH. A previous study showed that the critical residue of the active site distinguishes between malate dehydrogenase and lactate dehydrogenase, two enzymes that share high sequence similarity (Hannenhalli & Russell, 2000). The five groups of PtMDH genes have different intron-exon structures and different numbers of introns.…”

Section: Discussionmentioning

confidence: 99%

Genome-wide investigation of malate dehydrogenase gene family in poplar (Populus trichocarpa) and their expression analysis under salt stress

Chen

Zhang

et al. 2019

Preprint

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Malate dehydrogenase (MDH) is widely distributed in plants and animals, and plays an important role in many metabolic processes. However, there have been few studies on MDH genes in poplar. In this study, 16 MDH gene sequences were identified from the Populus trichocarpa genome and renamed according to their chromosomal locations. Based on phylogenetic analysis, the PtMDH genes were divided into five groups, and genes that grouped together all shared the same subcellular location and had similar sequence lengths, gene structures, and conserved motifs. Two pairs of tandem duplication events and three segmental duplication events involving five genes were identified from the 15 PtMDH genes located on the chromosomes. Each pair of genes had a Ka/Ks ratios <1, indicating that the MDH gene family of P. trichocarpa was purified during evolution. Based on the transcriptome data of P. trichocarpa under salt stress and qRT-PCR verification, the expression patterns of PtMDH genes under salt stress were analyzed. The results showed that most of the genes were upregulated under salt stress, indicating that they play a role in the response of poplar to salt stress. The PtmMDH1 gene can be used as an important salt-tolerant candidate gene for further investigations of molecular mechanisms. This study lays the foundation for functional analysis of MDH genes and genetic improvement in poplar.

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“…According to this, NF-κB was responsible for inflammatory reactions by mediating TNF-α, IL-1β, and IL-6 expressions in rats treated with doxorubicin [ 110 ]. The formation of superoxide radical(s) by doxorubicin exposure led to apoptosis [ 111 , 112 ]. Further, doxorubicin-treated animals showed cell death and apoptosis characterized by upregulation of Bax, down-regulation of Bcl2, increased mitochondrial permeability, and activation of caspase-3 in kidneys [ 106 ].…”

Section: Kidney and Mitochondriamentioning

confidence: 99%

The Effect of Polyphenols on Kidney Disease: Targeting Mitochondria

Ashkar

Bhullar

2022

Nutrients

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Mitochondrial function, including oxidative phosphorylation (OXPHOS), mitochondrial biogenesis, and mitochondria dynamics, are essential for the maintenance of renal health. Through modulation of mitochondrial function, the kidneys are able to sustain or recover acute kidney injury (AKI), chronic kidney disease (CKD), nephrotoxicity, nephropathy, and ischemia perfusion. Therapeutic improvement in mitochondrial function in the kidneys is related to the regulation of adenosine triphosphate (ATP) production, free radicals scavenging, decline in apoptosis, and inflammation. Dietary antioxidants, notably polyphenols present in fruits, vegetables, and plants, have attracted attention as effective dietary and pharmacological interventions. Considerable evidence shows that polyphenols protect against mitochondrial damage in different experimental models of kidney disease. Mechanistically, polyphenols regulate the mitochondrial redox status, apoptosis, and multiple intercellular signaling pathways. Therefore, this review attempts to focus on the role of polyphenols in the prevention or treatment of kidney disease and explore the molecular mechanisms associated with their pharmacological activity.

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Late effects of adriamycin single dose on fetal rat kidney—ultrastructural assessment

Cited by 6 publications

References 14 publications

Synthesis of Mn3O4 nanoparticles and their application to cancer cells

Synthesis of Mn3O4 nanoparticles and their application to cancer cells

Genome-wide investigation of malate dehydrogenase gene family in poplar (Populus trichocarpa) and their expression analysis under salt stress

The Effect of Polyphenols on Kidney Disease: Targeting Mitochondria

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