Late effects of radiation treatment of tongue and floor-of-mouth cancer on the dentition, saliva secretion, mucous membranes and the lower jaw

Pyykönen, Heikki; Malmström, Maria; Oikarinen, Valle J.; Salmo, M; Vehkalahti, Miira M.

doi:10.1016/s0300-9785(86)80028-x

Cited by 38 publications

(16 citation statements)

References 16 publications

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“…Die Latenzzeit bei höheren Dosen beträgt sechs bis sieben Monate [18,23,40]. Bei einer mittleren Beobachtungszeit von ungefähr fünf Jahren zeigte die Zahnhalsregion bestrahlter Patienten eine um den Faktor 10 höhere Inzidenz kariöser Läsionen gegenüber nicht bestrahlten Kontrollen [31]. Die typischen Befunde der Strahlenkaries werden in der chronologischen Abfolge deutlich.…”

Section: Diskussionunclassified

Chronische Strahlenfolgen an den Zahnhartgeweben (“Strahlenkaries”) Klassifikation und Behandlungsansätze

Grötz

Riesenbeck²,

Brahm

et al. 2001

Strahlenther Onkol

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The documentation of early radiation effects on dental hard tissues seems to be neglectable. On the other hand the documentation of Late radiation effects has a high clinical impact. The identification of an initial lesion at the high-risk areas of the neck and incisal part of the tooth can lead to a successful therapy as a major prerequisite for orofacial rehabilitation. An internationally standardized documentation is a basis for the evaluation of the side effects of radiooncotic therapy as well as the effectiveness of protective and supportive procedures.

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Section: Diskussionunclassified

Chronische Strahlenfolgen an den Zahnhartgeweben (“Strahlenkaries”) Klassifikation und Behandlungsansätze

Grötz

Riesenbeck²,

Brahm

et al. 2001

Strahlenther Onkol

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“…Hyposalivation, which is induced by irradiation [Frank et al, 1965], and dietary changes with concomitant alteration of the oral flora [Brown et al, 1975] are considered to be the most important etiological factors. In addition to the cervical region [Pyykönen et al, 1986], 'radiation caries' frequently occurs on buccal and oral smooth surfaces as well as on occlusal or incisal edges of the teeth [Jansma et al, 1993;Jongebloed et al, 1988;Willich et al, 1988]. However, these areas generally are considered as relatively caries-resistant in nonirradiated patients, suggesting the possibility of another cause as well as reduced salivary flow and altered microbial composition.…”

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confidence: 99%

Microradiographic and Microscopic Studies on in situ Induced Initial Caries in Irradiated and Nonirradiated Dental Enamel

1999

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The objective of this study was to evaluate the onset of initial demineralization in irradiated and nonirradiated human enamel. Enamel specimens were prepared from the lingual and buccal surfaces of 48 freshly extracted, caries–free third molars. Either the lingual or the buccal enamel specimen of each tooth was irradiated with 60 Gy. The remaining enamel sample was not irradiated. Two irradiated and two nonirradiated enamel specimens were inserted into both buccal aspects of each 12 intraoral mandibular appliances. The appliances were worn by 12 persons for 6 weeks throughout day and night. One side was brushed daily with a fluoride–free toothpaste. On the other side plaque was allowed to grow. Individual oral hygiene techniques were performed without any fluorides. During meals, the appliance was stored in 10% sucrose solution. The enamel specimens were cut perpendicular to the enamel surface. Subsequently, the slabs were ground to a thickness of 90 μm, and studied by means of TMR and microscopic techniques. Evaluated data did not show any differences between irradiated and nonirradiated enamel lesions (ANOVA). The onset of caries in irradiated enamel can be hampered by regularly performed oral hygiene techniques.

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“…Die Sialometrie ist das am häufigsten in Therapiestudien zur Xerostomie gewählte Zielkriterium [10,13,17,24] und wird oft zur Beurteilung der Speicheldrüsenrestfunktion nach Bestrahlung herangezogen [15,22,26]. Die in der Literatur beschriebene drastische Verminderung der Flußraten während und kurz nach Bestrahlung [26] wurde durch die vorliegende Studie bestätigt.…”

Section: Sialometrieunclassified

“…In vielen Therapiestudien zur Radioxerostomie wurden subjektive Befunde als Zielkriterium ausgewertet [17,22]. Ein Vorteil dieser Daten zur Mundgesundheit und zu Kau-, Schluck-oder Sprechfunktion liegt in der Eruierung von Variablen, die letztlich das klinische Ziel der Therapie darstellen.…”

Section: Rtog-scoreunclassified

Prospektive, doppelblinde Therapiestudie zur Prophylaxe der Radioxerostomie durch Cumarin/Troxerutin bei Patienten mit Kopf-Hals-Karzinomen

Grötz

Zepelin

Kohnen³

et al. 1999

Strahlentherapie und Onkologie

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The results give support for an advantageous effect of Venalot Depot in the treatment of radiogenic sialadenitis and mucositis. In even a small number of evaluable patients, early clinical effects of irradiation (RTOG-score) were less pronounced in the active treatment group than in the placebo group, but the sample size was too low to prove statistically also the benefit of coumarin/troxerutine with the scintigraphic method. Sialometry seems not suitable for the assessment of early radiation effects.

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Late effects of radiation treatment of tongue and floor-of-mouth cancer on the dentition, saliva secretion, mucous membranes and the lower jaw

Cited by 38 publications

References 16 publications

Chronische Strahlenfolgen an den Zahnhartgeweben (“Strahlenkaries”) Klassifikation und Behandlungsansätze

Chronische Strahlenfolgen an den Zahnhartgeweben (“Strahlenkaries”) Klassifikation und Behandlungsansätze

Microradiographic and Microscopic Studies on in situ Induced Initial Caries in Irradiated and Nonirradiated Dental Enamel

Prospektive, doppelblinde Therapiestudie zur Prophylaxe der Radioxerostomie durch Cumarin/Troxerutin bei Patienten mit Kopf-Hals-Karzinomen

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