The Meng'entaolegai Ag-Pb-Zn-In polymetallic deposit is located in the eastern part of Inner Mongolia. It consists of a hydrothermal quartz-sulfide vein deposit hosted within a Hercynian granite massif which is about 400 km 2 in size. More than 40 orebodies are found in the orefield which is 6 km in length from east to west and 200 to 1,000 m in width from south to north. All orebodies are controlled by E-W trending faults. Economic resources are dominated by Pb and Zn (reserves of Pb and Zn are 0.17 Mt and 0.37 Mt, and their grades are 1% and 2.3%, respectively), with Ag, Sn, In and Cd (1,800 t Ag, >2,000 t Sn, >500 t In and 1800 t Cd) as by-products. values from 4.8‰ to 7.9‰) of the fluid inclusion water in quartz show that the oreforming fluid has a mainly magmatic source. The lead isotopic compositions of ore are relatively homogeneous and are significantly lower than those of feldspars and whole rock of the Hercynian Meng'entaolegai granite and the Yanshanian Duerji granite. Neither these granites nor the regional basement Precambrian metamorphic rocks provided ore with lead. By comparison, ore lead isotopic composition is the same as that of E-W trend diorite dykes which intruded the granites and this indicates that the ore lead is probably derived from magamatism which is related to these dykes. We considered therefore that although orebodies occurred within the Hercynian Meng'entaolegai granite, the deposit origin is not related to this stage of magmatism.Keywords: Meng'entaolegai, Inner Mongolia in China, polymetallic deposit, isotopes, ore-forming material source are the direct wall rocks of orebodies, with their middle and upper parts being eroded; the orebodies are veinshaped and controlled strictly by fault structures; gold and/or silver are the main economic metals. Generally speaking, magmatic hydrothermal deposits mostly occur in the top parts of igneous massifs, in the contacts with, or even within the country rocks. So, there has been a variety of proposed hypotheses concerning the origins of such fault-controlled vein metallic ore deposits, for instance the magmatic hydrothermal origin (Li, 1994;Wang et al., 1992), the magmatic rock leaching-reworking origin (Wang et al